Comparison of Salivary Cortisol and α‐amylase Levels and Psychological Profiles in Patients with Burning Mouth Syndrome

Nosratzehi, Tahereh; Salimi, Saeedeh; Parvaee, Azadeh

doi:10.1111/scd.12214

Cited by 30 publications

(57 citation statements)

References 24 publications

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“…Additionally, previous studies have shown controversial results regarding the salivary cortisol levels in BMS patients. Amenábar et al (3) and Kim et al (7) have shown elevated cortisol levels in BMS patients, which is in disagreement with Nosratzehi et al (8) and de Souza et al (9).…”

Section: Discussionmentioning

confidence: 90%

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Salivary Cortisol Levels and Burning Symptoms in Patients with Burning Mouth Syndrome before and after Low Level Laser Therapy: a Double Blind Controlled Randomized Clinical Trial

Škrinjar¹,

Brzak²,

Vidranski³

et al. 2020

Acta Stomatol Croat

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Razina kortizola i simptomi žarenja kod bolesnika sa sindromom pekućih usta prije i nakon liječenja niskoenergijskim laserom: dvostruko slijepa, kontrolirana i randomizirana klinička studija Uvod Sindrom pekućih usta (SPU) poremećaj je obilježen simptomima žarenja sluznice usta, bez vidljivih patoloških promjena (1). Etiologija mu je nejasna, iako se kao mogući uzroci spominju poremećaji središnjeg (2) ili perifernog živčanog sustava. Najčešće zahvaćena mjesta su prednje dvije trećine jezika, iako se može pojaviti na bio kojem intraoralnom mjestu (3). Najčešće obolijevaju žene u peri i postme-ACTA STOMATOLOGICA CROATICA www.ascro.hr

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Section: Discussionmentioning

confidence: 90%

“…Results from the literature point out that cortisol levels in saliva are increased in BMS patients as indicator of stress conditions (3,7). However, Nosratzehi et al (8) and de Souza et al (9) have shown that differences between salivary cortisol levels among BMS patients and control were not significant.…”

Section: Introductionmentioning

confidence: 98%

Salivary Cortisol Levels and Burning Symptoms in Patients with Burning Mouth Syndrome before and after Low Level Laser Therapy: a Double Blind Controlled Randomized Clinical Trial

Škrinjar¹,

Brzak²,

Vidranski³

et al. 2020

Acta Stomatol Croat

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“…The contribution from oxidative stress must also be considered, given that stress‐related hormonal alterations in postmenopausal BMS patients may affect MUC1 expression and burning pain perception (Kang et al, 2017). Stress may, in fact, play a relevant role on BMS pathophysiology, because the stress‐related enzyme α‐amylase is also upregulated in saliva from BMS patients (Imura et al, 2016; Nosratzehi et al, 2017). Reports suggesting altered levels of reactive oxygen species (ROS) in saliva (Tvarijonaviciute, Aznar‐Cayuela, Rubio, Ceron, & Lopez‐Jornet, 2017), in addition to alterations in total oxidant capacity and biological antioxidant potential as iron‐reducing activity in blood (Tatullo et al, 2012) of BMS patients, support the contribution of oxidative stress to BMS pathogenesis.…”

Section: Pathophysiology Of Bmsmentioning

confidence: 99%

Recent advances in the understanding of the aetiology and therapeutic strategies in burning mouth syndrome: Focus on the actions of cannabinoids

Pereira

Velasquez

Duggan

et al. 2020

Eur J of Neuroscience

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Burning mouth syndrome (BMS) is a neuropathic pain disorder associated with a burning sensation on oral mucosal surfaces with frequently reported xerostomia, dysgeusia and tingling or paraesthetic sensations. However, patients present no clinically evident causative lesions. The poor classification of the disorder has resulted in a diagnostic challenge, particularly for the clinician/dentist evaluating these individuals. Major research developments have been made in the BMS field in recent years to address this concern, principally in terms of the pathophysiological mechanisms underlying the disorder, in addition to therapeutic advancements. For the purpose of this review, an update on the pathophysiological mechanisms will be discussed from a neuropathic, immunological, hormonal and psychological perspective. This review will also focus on the many therapeutic strategies that have been explored for BMS, including antidepressants/antipsychotics, non‐steroidal anti‐inflammatories, hormone replacement therapies, phytotherapeutic compounds and non‐pharmacological interventions, overall highlighting the lack of controlled clinical studies to support the effectiveness of such therapeutic avenues. Particular focus is given to the cannabinoid system and the potential of cannabis‐based therapeutics in managing BMS patients.

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“…Due to the psychosomatic profile of this aetiology of this disease, stress-related proteins (such as cortisol and α -amylase) have been related to its presentation [ 122 , 123 ]. There are few studies investigating the role of salivary Igs in this pathology, and the existing ones have contradictory results.…”

Section: The Salivary Proteome In the Health-illness Spectrummentioning

confidence: 99%

Protein-Based Salivary Profiles as Novel Biomarkers for Oral Diseases

et al. 2018

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The Global Burden of Oral Diseases affects 3.5 billion people worldwide, representing the number of people affected by the burden of untreated dental caries, severe periodontal disease, and edentulism. Thus, much more efforts in terms of diagnostics and treatments must be provided in the fight of these outcomes. In this sense, recently, the study of saliva as biological matrix has been identified as a new landmark initiative in the search of novel and useful biomarkers to prevent and diagnose these conditions. Specifically, saliva is a rich reservoir of different proteins and peptides and accessible due to recent advances in molecular biology and specially in targeted and unbiased proteomics technologies. Nonetheless, emerging barriers are an obstacle to the study of the salivary proteome in an effective way. This review aims at giving an overall perspective of salivary biomarkers identified in several oral diseases by means of molecular biology approaches.

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Comparison of Salivary Cortisol and α‐amylase Levels and Psychological Profiles in Patients with Burning Mouth Syndrome

Abstract: The results showed higher salivary levels of cortisol and α-amylase in patients with BMS compared to healthy individuals. Psychological problem was prevalent in patients.

Cited by 30 publications

References 24 publications

Salivary Cortisol Levels and Burning Symptoms in Patients with Burning Mouth Syndrome before and after Low Level Laser Therapy: a Double Blind Controlled Randomized Clinical Trial

Salivary Cortisol Levels and Burning Symptoms in Patients with Burning Mouth Syndrome before and after Low Level Laser Therapy: a Double Blind Controlled Randomized Clinical Trial

Recent advances in the understanding of the aetiology and therapeutic strategies in burning mouth syndrome: Focus on the actions of cannabinoids

Protein-Based Salivary Profiles as Novel Biomarkers for Oral Diseases

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