Comparison of Some Properties of Pronethalol and Propranolol

Daniel Bovet: 1957 Nobel Laureate and Developer of Succinylcholine

“…20 Also in the manner of Bovet's work on antihistamines, Black found betablockers including propranolol. 21 The seminal Bovet work on sulfanilamide permitted Elion and Hitchings to develop, for instance, trimethaprim-sulfa. 22,23 It would be a Herculean task to list all of the ramifications of the seminal work of Daniel Bovet.…”

Synthesis and Reactions of Halo‐, Arylazo‐substituted 3‐(3‐(1‐naphthyl)acryloyl)tropolones. Formation of (Naphthalen‐1‐yl)vinyl)substituted Heterocycle‐fused Troponoid Compounds

“…Thus, it has been reported that the chalcones reacted with hydroxylamine [22][23][24][25] and hydrazine [26][27][28][29][30] to afford, respectively, diphenyl-substituted isoxazolines and pryazolines. On the other hand, we found that 3-acetyl 9 and 3-cinnamoyltropolone 13 reacted with various nucleophilic reagents bearing two reactive sides to give a wide variety of heterocycle-fused troponoid compounds. 31 Reactions of 3-(3-(1-naphthyl)acryloyl)tropolone (3) with hydroxylamine in refluxing ethanol allowed us to obtain 3-[2-(1-naphthyl)vinyl]-8H-cyclohepta-[d]isoxazol-8-one (9) in 47.7% yield.…”

“…A number of pharmaceutical and agricultural agents have a naphthalene framework. 12,13 Because of the wide variety of practical applications of the naphthalene nucleus as a building block, it is of paramount importance to develop synthetic strategies around this nucleus, in order to gain easy access to a variety of naphthalene derivatives. Substitution at position 1 of the naphthalene ring, such as naphazoline and terbinafine, [14][15][16] is of particular interest within this group.…”

The ins and outs of adrenergic signaling

“…It took two major developments to ascertain that adrenergic receptors were real and even pharmacologically useful entities: the development of specific and medically useful antagonists, notably propranolol, the prototypical β-blocker [12], and the demonstration by radioligand binding of stereospecific binding sites for adrenaline and synthetic ligands of higher affinity and specificity [13]. However, it was ultimately the biochemical purification of these receptors from various native sources and their subsequent reconstitution into functional systems that unequivocally proved their existence (Fig.…”