Comparison of the Actions of Diazepam and Lorazepam

Dundee, J. W.; Mcgowan, W.A.W.; Lilburn, J.K.; Mckay, A.C.; Hegarty, JE

doi:10.1093/bja/51.5.439

Cited by 67 publications

(36 citation statements)

References 12 publications

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“…These results confirm the amnesic effects reported with lorazepam by many authors (Pandit et al, 1976;George and Dundee, 1977;Dundee et al, 1979;Brown et af., 1982;Healey et al, 1983;Block and Berchou, 1984;Lister and File, 1984;Shader et al, 1986;Curran et af., 1987;Mattila et al, 1988;Preston et al, 1988) and the memory deficits observed in this study again demonstrate the difference between lorazepam and clobazam (Siegfried et al, 1981;Saletu et uf., 1985;Patat et al, 1988).…”

Section: Discussionsupporting

confidence: 91%

“…The study of psychomotor performance and cognitive function confirmed the very marked sedative effect of lorazepam which is manifested by an increased reaction time and a decrease in tapping and number of correct responses to a mental arithmetic test (Seppala et al, 1976(Seppala et al, , 1982Dundee et al, 1979;File and Bond, 1979;Aranko et al, 1985;Curran et al, 1987;Grunberger et al, 1988;Mattila et al, 1988;Saletu et al, 1988). The greater sedative effect of lorazepam has, moreover, been confirmed, comparatively with clobazam, in a quantitative EEG study (Saletu et al, 1985).…”

Section: Discussionmentioning

confidence: 73%

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Study of effects of clobazam and lorazepam on memory and cognitive functions in healthy subjects

Patat¹,

Klein²,

Surjus³

et al. 1991

Human Psychopharmacology

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This was a double-blind, placebo-controlled crossover study in 15 healthy female volunteers. It consisted of five sessions, separated by 1 week wash-out between sessions. The purpose of the trial was to study the potential amnesic and sedative activity of clobazam and lorazepam, and the potential antagonism between these effects under the joint influence of a high noise level and intense intermittent light stimulation (ILS), aimed at increasing the level of alertness. The study drugs were administered as a single daily oral dose. The amnesic and sedative effects were evaluated by objective measurements (digit span, Buschke selective reminding test, critical flicker fusion, reaction time, tapping, mental arithmetic test) and subjective measurements (visual analogue scale and adverse effect questionnaire) before each administration, then 1 h, 2 h, 2 5 h, 3 h, 4 h and 7 h post-dosing. An analysis of variance according to a balanced Latin square design was performed. Clobazam, at a dosage of 10 mg, was devoided of sedative and amnesic effects; at a dosage of 30 mg it induced only moderate memory disturbances. In contrast, lorazepam, administered at doses of 1 and 3 mg, produced marked and dose-dependent disturbances of memory, alertness and cognitive functions. The use of visual and sound stimuli, designed to increase the level of alertness, did not counteract the sedative effects induced by lorazepam.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 73%

Study of effects of clobazam and lorazepam on memory and cognitive functions in healthy subjects

Patat¹,

Klein²,

Surjus³

et al. 1991

Human Psychopharmacology

View full text Add to dashboard Cite

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“…At the chosen doses both drugs could be considered to be equally potent as evidenced by the equivalence of their effects upon sedation and explicit memory performance (see e.g. Dundee et al, 1979;Kothary et al, 1981;Sellal et al, 1992;Vidailhet et al, 1994). The time of administration was designed so that action peak of both drugs was achieved at the same time (1 hour after the intake of diazepam vs. 2 hours after the intake of lorazepam).…”

Section: Experimental Procedures and Drugsmentioning

confidence: 99%

Some facilitatory effects of lorazepam on dynamic visual binding

2005

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Rationale: The benzodiazepine, lorazepam enhances the potential for inhibitory GABA A (-aminobutyric acid) synapses in the cortex to stabilize postsynaptic, excitatory activity by synchronizing discharge rates at frequencies of around 40 Hz. Treatment with lorazepam also affects contour integration processes, suggesting GABA A -mediated synchronization plays a role in visuo-spatial organization. This conclusion is supported by other physiological studies that link visual feature integration with neuronal synchronization. Conclusions: This finding supports the idea that GABA A -enhanced inhibitory synchronization mediates continuity coding during early visual processing. Objectives

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“…Clinically it was not harmful as they were below 20 mmHg which was graded "nil" by Dundee et al 12 So in our study there was no adverse effect on cardiovascular system by any drug group, which correlates with the finding of Norris et al, Dundee et al, Suri Y, Agelink et al and Jakobsen H who found no adverse cardiovascular responses with BZDs. [23][24][25][26][27] Benzodiazepines can influence autonomic neurocardiac regulation in man, probably through their interaction with the gamma-aminobutyric acid A-receptor chloride ion channel complex. The pattern of findings suggests that intravenous midazolam, diazepam and lorazepam influence human autonomic neuro-cardiac regulation in a biphasic way.…”

Section: Discussionmentioning

confidence: 99%

Benzodiazepine hypnotics as oral preanaesthetic medication: a comparative clinical study

Dasgupta

Sen

et al. 2016

Int Surg J

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Background:An ideal pre-medicant should allay fear and anxiety without producing its effect on vital functions of the body and body chemistry, with minimal depression of the respiratory and circulatory systems. The ideal pre-medicant with all good qualities and no side effects at all is yet to be found. The search for a drug which will be an appropriate pre-anesthetic medication is still going.Methods: Four drugs of BZD group namely diazepam, nitrazepam, lorazepam, and oxazepam were chosen as oral pre-anesthetic medication. Total number of cases were 100, of which 25 patients belonging to each group of drug respectively. Standard doses of oxazepam (30 mg), nitrazepam (5 mg), diazepam (10 mg) and lorazepam (2 mg) by oral route were administered. All study participants were examined night before operation to observe the following clinical parameters like level of apprehension, excitement, blood pressure, heart rate, respiration (rate, rhythm and minute volume).Results:Diazepam and nitrazepam produced fair degree of sedation whereas oxazepam appears to be lagging behind. So far as anxiolysis is concerned, all the drugs appear to be good anxiolytics. Nausea, vomiting and dizziness are some of the problems which may occasionally be faced by this group of drug. On reassessment of patients 60 minutes after premedication, it was revealed that the efficacy so as anxiolysis and sedative effect is concerned was in the following order, lorazepam headed the list; diazepam and nitrazepam followed closely and oxazepam was at the bottom. Toxicity in all the four drugs were minimal. The degree of sleepiness varied from drug to drug. Ninety minute after premedication patients were found to be in a better state of sedation than at 60 minute’s level in all the four groups. The degree of sedation and anxiolysis was in the same order as that of 60 minutes level.Conclusions:The overall impression was that four members of the benzodiazepines, serve as as a good premedication in the absence of pain. The sedation and anxioysis produced by them are of fair degree even when given orally. Side effects produced were minimal except in the lorazepam group when they are used as night time sedative. Given orally only lorazepam is capable of producing anterograde amnesia.

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Comparison of the Actions of Diazepam and Lorazepam

Cited by 67 publications

References 12 publications

Study of effects of clobazam and lorazepam on memory and cognitive functions in healthy subjects

Study of effects of clobazam and lorazepam on memory and cognitive functions in healthy subjects

Some facilitatory effects of lorazepam on dynamic visual binding

Benzodiazepine hypnotics as oral preanaesthetic medication: a comparative clinical study

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