Comparison of the chemical composition and biological effects of the roots, branches and leaves of Heteropterys tomentosa A. Juss

Paula-Freire, Lyvia Izaura Gomes; Mendes, Fúlvio Rieli; Molska, Graziella Rigueira; Duarte-Almeida, Joaquim Maurício; Carlini, E. A.

doi:10.1016/j.jep.2012.12.004

Cited by 19 publications

(15 citation statements)

References 22 publications

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“…The rutin ratio found in this study was greater (0.9-1.9 mg/g) than that obtained (0.3 mg/g) from Heteropterys tomentosa leaves (Paula-Freire et al, 2013). This work confirmed Z. jujuba leaves' richness in rutin compared to that found in the pulp (Elaloui et al, 2014a,b).…”

Section: Discussionsupporting

confidence: 81%

Phytoconstituents of leaf extracts of Ziziphus jujuba Mill. plants harvested in Tunisia

Elaloui

Laamouri

Ennajah

et al. 2016

Industrial Crops and Products

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The present study aimed to determine the phytoconstituent compositions of the leaves of four Ziziphus jujuba ecotypes (Choutrana, Mahdia, Mahres and Sfax). The chromatographie peaks of 18 compounds, including nine major fatty acids, live sterols, two triterpene alcohols and two methysterols, were quan tified by the capillary gaseous chromatography method. The major fatty acids identified were linolenic (42.04%) and palmitic (23.04%). Unsaturated fatty acids ranged between 53% and 60%. The predominant sterols (mg/100 g) were 13-sitosterol (4036) and stigmasterol (24. 18). Cycloartenol (68.55 mg/100 g) and citrostadienol (12.27 mg/lOOg) were the major metylsterols. Methylene cydoartanol ranged between 1.2 mg/100 g (Sfax) and 1.5 mg/100 g (Mahdia). Total phenolic content measured by Folin-ciocalteux ranged from 3.97 mg GAE/g to 6.04 mg GAE/g. The predominant flavonoids identified by HPLC were apigenin (6.1 mg/g) and rutin (1.91 mg/g). The fatty acids and flavonoids in the Z. jujuba leaves were responsible for their therapeutic and phar maceutical effects. This could explain whyTunisian people traditionally use it as medicine to treat several pathologies.

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Section: Discussionsupporting

confidence: 81%

Phytoconstituents of leaf extracts of Ziziphus jujuba Mill. plants harvested in Tunisia

Elaloui

Laamouri

Ennajah

et al. 2016

Industrial Crops and Products

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“…[26]. However, the hydroalcoholic extracts of roots, branches, and leaves of Heteropterys tomentosa A. Juss showed no effects when evaluated in animal models of stress and learning/memory [27], and no influence on the apoptosis of the hippocampal cells of aged rats [28]. Interestingly, even when Heteropterys species could be considered relevant from the neuropharmacological perspective, the studies about the chemical composition of the active CNS extracts are scarce.…”

Section: Resultsmentioning

confidence: 99%

Heteropterys cotinifolia: A Neuropharmacological and Phytochemical Approach with Possible Taxonomic Implications

Huerta-Reyes

Zamilpa

Álvarez-Chimal

et al. 2013

The Scientific World Journal

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Heteropterys cotinifolia (Malpighiaceae) has been used in traditional Mexican medicine mainly for the treatment of nervous disorders. However, the specific neuropharmacological activities responsible for this use remain to be defined. The present study evaluates the antidepressant and anxiolytic effects produced by the methanolic extract of Heteropterys cotinifolia and the influence of such effects on motor activity in ICR mice. Our results show that the methanolic extract of Heteropterys cotinifolia produces a dose-dependent antidepressant effect in the forced swimming test in mice at doses from 31 to 310 mg/kg, with no reduction of mice locomotion. However, no anxiolytic properties were observed. Our findings suggest that the main extract compounds identified as chlorogenic acid and rutin may be involved in the antidepressant effects. To our knowledge, the present study constitutes the first report of pharmacological and phytochemical data of Heteropterys cotinifolia. The presence of flavonoids in the methanolic extract of Heteropterys cotinifolia may also provide further data to characterize taxonomically this species in order to be distinguished from others species closely related and belonging to the same genus.

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“…Animals were randomly allocated into four groups (n = 10/group): no stress (NS); no stress supplemented with royal jelly (NSRJ); stress (S); and stress supplemented with royal jelly (SRJ). The animals were exposed to stress by restraint and cold, using the method of Paula-Freire et al [ 21 ]. These method effectively mimics a condition of physical and psychological stress [ 2 ].…”

Section: Methodsmentioning

confidence: 99%

Adaptogenic potential of royal jelly in liver of rats exposed to chronic stress

et al. 2018

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Restraint and cold stress increase both corticosterone and glycemia, which lead to oxidative damages in hepatic tissue. This study assessed the effect of royal jelly (RJ) supplementation on the corticosterone level, glycemia, plasma enzymes and hepatic antioxidant system in restraint and cold stressed rats. Wistar rats were allocated into no-stress, stress, no-stress supplemented with RJ and stress supplemented with RJ groups. Initially, RJ (200mg/Kg) was administered for fourteen days and stressed groups were submitted to chronic stress from the seventh day. The results showed that RJ supplementation decreases corticosterone levels and improves glycemia control after stress induction. RJ supplementation also decreased the body weight, AST, ALP and GGT. Moreover, RJ improved total antioxidant capacity, SOD activity and reduced GSH, GR and lipoperoxidation in the liver. Thus, RJ supplementation reestablished the corticosterone levels and the hepatic antioxidant system in stressed rats, indicating an adaptogenic and hepatoprotective potential of RJ.

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Comparison of the chemical composition and biological effects of the roots, branches and leaves of Heteropterys tomentosa A. Juss

Abstract: The tests employed in this study did not show evidence of adaptogenic activity in the three extracts of Heteropterys tomentosa.

Cited by 19 publications

References 22 publications

Phytoconstituents of leaf extracts of Ziziphus jujuba Mill. plants harvested in Tunisia

Phytoconstituents of leaf extracts of Ziziphus jujuba Mill. plants harvested in Tunisia

Heteropterys cotinifolia: A Neuropharmacological and Phytochemical Approach with Possible Taxonomic Implications

Adaptogenic potential of royal jelly in liver of rats exposed to chronic stress

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