Comparison of the effect of vitamin E, vitamin D and ginger on the severity of primary dysmenorrhea: a single-blind clinical trial

Pakniat, Hamideh; Chegini, Venus; Ranjkesh, Fatemeh; Hosseini, Mohammad Ali

doi:10.5468/ogs.2019.62.6.462

Cited by 37 publications

(50 citation statements)

References 20 publications

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“…Visual analog scale (VAS) scores were used to determine dysmenorrhea severity ( 13 ) . A study used VAS scores to classify patients with primary dysmenorrhea ( 14 ) . Participants were then divided into the following three groups based on their level of reported pain: VAS scores of 8-10 comprised the severe primary dysmenorrhea group (n=30), 4-7 the moderate primary dysmenorrhea group (n=30), and 1-3 the mild primary dysmenorrhea group (n=30).…”

Section: Methodsmentioning

confidence: 99%

Relation between uterine morphology and severity of primary dysmenorrhea

Şentürk¹

2020

tjod

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Objective: This study aimed to evaluate whether uterine dimensions including uterine volume, uterine shape, uterine length, cervix length, and cervix thickness measurements have a role in the severity of primary dysmenorrhea in virgin girls. Materials and Methods: Enrollment included 90 virgin girls suffering from primary dysmenorrhea. The girls were divided into three groups according to the severity of dysmenorrhea, which was determined by the visual analog scale (VAS). Patients with VAS scores of 8-10 comprised the severe primary dysmenorrhea group (n=30), 4-7 the moderate primary dysmenorrhea group (n=30), and 1-3 the mild primary dysmenorrhea group (n=30). Uterine characteristics including uterine volume, uterine shape, uterine length, cervix length, and cervix thickness were measured by a high-resolution four-dimensional ultrasound device with real-time capacity. They were recorded to determine if they can be predictors of dysmenorrhea severity. Results: Girls with severe primary dysmenorrhea were more likely to complain of midline pain as opposed to mild and moderate cases with lateral or diffuse pain. None of the uterine characteristics on ultrasonography examination were significant for predicting the severity of primary dysmenorrhea. There were no significant positive correlations between the dysmenorrhea severity and uterine corpus length, cervix length, and uterine volume degree. Any combination of the measured uterine features was not predictive for determining the severity of dysmenorrhea. Conclusion: Ultrasonographic measurements of uterine dimensions in virgins have low accuracy for predicting the severity of pain in primary dysmenorrhea.

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Section: Methodsmentioning

confidence: 99%

Relation between uterine morphology and severity of primary dysmenorrhea

Şentürk¹

2020

tjod

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“…After screening titles and abstracts, 25 review articles and meta-analyses and 120 studies that did not match the inclusion criteria were eliminated and 76 potentially eligible studies were identified. After excluding nine studies written in languages other than English, three studies for which valid data could not be extracted, and 55 with control group not meeting the requirements, nine studies 13,[16][17][18][19][20][21][22][23] were finally included in this meta-analysis. The PRISMA flowchart describing the study selection process is presented in Figure 1.…”

Section: Description and Characteristics Of Included Studiesmentioning

confidence: 99%

“…Pain intensity was reported as the outcome indicator in nine studies, 13,[16][17][18][19][20][21][22][23] but significant heterogeneity was detected (I 2 ¼ 94.8%). Using the random-effect model, pain intensity was significantly weaker in the trial group than in the control group (WMD ¼ 1.913, 95% CI ¼ 1.244-2582, P < 0.001; Figure 2a and Table 3).…”

Section: Pain Intensitymentioning

confidence: 99%

Efficacy of herbal medicine (cinnamon/fennel/ginger) for primary dysmenorrhea: a systematic review and meta-analysis of randomized controlled trials

Yang²,

Wang

2020

J Int Med Res

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Objective To assess the efficacy of herbal medicine (cinnamon/fennel/ginger) for treating primary dysmenorrhea. Methods Relevant studies were searched in multiple databases. The weighted mean difference (WMD) was used as the effect indicator for measurement data, and each effect size was given estimates and 95% confidence intervals (CIs). Results Nine studies with 647 patients were selected. Compared with the results in the control group, pain intensity was significantly relieved in the trial group when assessed by the intervention (cinnamon vs. placebo: WMD = 1.815, 95% CI = 1.330–2.301; fennel vs. placebo: WMD = 0.528, 95% CI = 0.119–6.829; ginger vs. placebo: WMD = 2.902, 95% CI = 2.039–3.765), observation period (one cycle: WMD = 2.061, 95% CI = 0.815–3.307; one cycles: WMD = 1.831, 95% CI = 0.973–2.690), and study quality (high quality: WMD = 2.224, 95% CI = 1.488–2.960). Pain duration was significantly shorter in the trial group (cinnamon vs. placebo: WMD = 16.200, 95% CI = 15.271–17.129). No publication bias was observed for either outcome. Conclusions For primary dysmenorrhea, cinnamon/fennel/ginger effectively reduced pain intensity, and cinnamon shortened the duration of pain. Further studies are needed to confirm our results.

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“…Calciferol, or the active form of vitamin D (Vit D), also plays a large role in regulating prostaglandin levels [ 19 ]. In other words, calcium homeostasis, under the influence of Vit D levels, can effectively relieve dysmenorrhea [ 20 ]. In this aspect, an inverse relationship was observed between dairy consumption and dysmenorrhea.…”

Section: Introductionmentioning

confidence: 99%

Role of vitamin D and calcium in the relief of primary dysmenorrhea: a systematic review

et al. 2021

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Dysmenorrhea is one of the well-established problems among women of reproductive age and can have adverse effects on the quality of life of the individual. Some studies suggest a relationship between vitamin D (Vit D) and calcium deficiency and the emergence of early dysmenorrhea. Accordingly, a systematic study was performed to investigate the role of calcium and Vit D in the relief of primary dysmenorrhea. A systematic literature search was performed in PubMed, Web of Science, Scopus, Science Direct, and Google Scholar for papers published between 2010 and 2020. The Consolidated Standards of Reporting Trials and Strengthening the Reporting of Observational Studies in Epidemiology checklists were used to assess the quality of the studies. The risk of bias was assessed using the Cochrane risk-of-bias assessment tool. Low calcium levels lead to an increase in uterine muscle contraction and can cause pain after decreased uterine blood flow. Furthermore, low levels of Vit D can increase primary dysmenorrhea by increasing prostaglandin production or reducing intestinal calcium absorption. That being the case, Vit D and calcium intake can be effective in reducing the severity of primary dysmenorrhea and in reducing the rate of analgesic use. Low levels of Vit D and calcium are inversely related to the severity of primary dysmenorrhea, and Vit D and calcium intake can reduce the severity of primary dysmenorrhea and its associated systemic symptoms. Therefore, the use of calcium and Vit D supplements can be recommended to relieve dysmenorrhea.

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Comparison of the effect of vitamin E, vitamin D and ginger on the severity of primary dysmenorrhea: a single-blind clinical trial

Cited by 37 publications

References 20 publications

Relation between uterine morphology and severity of primary dysmenorrhea

Relation between uterine morphology and severity of primary dysmenorrhea

Efficacy of herbal medicine (cinnamon/fennel/ginger) for primary dysmenorrhea: a systematic review and meta-analysis of randomized controlled trials

Role of vitamin D and calcium in the relief of primary dysmenorrhea: a systematic review

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