Comparison of the effect of lavender and bitter orange on anxiety in postmenopausal women: A triple-blind, randomized, controlled clinical trial

Farshbaf‐Khalili, Azizeh; Kamalifard, Mahin; Namadian, Mahsa

doi:10.1016/j.ctcp.2018.02.004

Cited by 39 publications

(31 citation statements)

References 21 publications

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“…Farshbaf-Khalili et al also compared the effects of lavender and bitter orange on allaying anxiety in menopausal women. Their results revealed the benefits of both types of aromatherapy, however no significant difference was observed between two groups by inhaling the plants (29), which is not consistent with the present study.…”

Section: Discussioncontrasting

confidence: 99%

Comparing the Aromatherapeutic Effects of Orange and Lavender Essential Oils on Anxiety and Physiological Indicators in Patients Undergoing Coronary Angiography: A Clinical Trial Study

2019

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Background: Anxiety is one of the common complications resulting from invasive diagnostic methods, especially coronary angiography. It affects physiological responses of the patient and jeopardizes his/her vital signs in the angiography suite. Aromatherapy has suggested to reduce anxiety. Objectives: In this regard, the present study aimed at comparing the effects of orange and lavandula (lavender) essential oils on anxiety and physiological parameters of patients undergoing coronary angiography. Methods: This clinical trial was performed on 101 patients undergoing coronary angiography who were admitted to the Fatemeh Al-Zahra Hospital in Sari, northern Iran in 2018. Convenience sampling was done and the subjects were randomly divided into three groups, including the control, lavender and orange groups. Data collection was done using a demographic and disease questionnaire, Spielberger's state-trait anxiety inventory (STAI), a sheet to record physiological variations, a barometer and a second timer. The obtained data were analyzed by SPSS 22 using chi-square test, Fisher's exact test, one-way ANOVA, paired t-test, Tukey's post-hoc test, Kruskal-Wallis test, paired Wilcoxon test and Mann-Whitney U test. Results: The results indicated a significant difference in the mean anxiety score between the lavender and control groups as well as the orange and control groups (P < 0.001); a significant difference was also observed between the orange and lavender groups after the intervention (P < 0.001). Furthermore, systolic blood pressure, pulse rate and respiration rate decreased significantly in subjects exposed to the lavender and orange essential oils compared to the control group (P < 0.001). Conclusions: According to the findings, orange and lavender aromatherapy could relieve anxiety in patients undergoing angiography. Accordingly, this intervention can be adopted as an effective measure in anxiety-ridden situations, like diagnostic procedures.

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Section: Discussioncontrasting

confidence: 99%

Comparing the Aromatherapeutic Effects of Orange and Lavender Essential Oils on Anxiety and Physiological Indicators in Patients Undergoing Coronary Angiography: A Clinical Trial Study

2019

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“…It was proven to be effective in reducing preoperative anxiety before minor operations [ 69 ]. Neroli EO reduced the mean anxiety scores in postmenopausal women [ 70 ]. It exerted its antianxiety effects by regulating 5-HT receptors in rats [ 57 ].…”

Section: Biological Propertiesmentioning

confidence: 99%

Biological Activities and Safety of Citrus spp. Essential Oils

Dosoky

Setzer

2018

IJMS

273

186

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Citrus fruits have been a commercially important crop for thousands of years. In addition, Citrus essential oils are valuable in the perfume, food, and beverage industries, and have also enjoyed use as aromatherapy and medicinal agents. This review summarizes the important biological activities and safety considerations of the essential oils of sweet orange (Citrus sinensis), bitter orange (Citrus aurantium), neroli (Citrus aurantium), orange petitgrain (Citrus aurantium), mandarin (Citrus reticulata), lemon (Citrus limon), lime (Citrus aurantifolia), grapefruit (Citrus × paradisi), bergamot (Citrus bergamia), Yuzu (Citrus junos), and kumquat (Citrus japonica).

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“…The genus Lavandula includes more than 30 species and it is widely distributed in the lands surrounding Mediterranean Sea and in the archipelagoes of the Atlantic Ocean [ 7 ]. Lavender aromatherapy has been proven to reduce preoperative anxiety [ 8 ] or anxiety in postmenopausal women [ 9 ]. In a recent study, lavender oil was found to be more potent than ibuprofen in alleviating stress related disorders in rats subjected to restraint stress [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Lavandula angustifolia Essential Oil and Linalool Counteract Social Aversion Induced by Social Defeat

et al. 2018

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Many vegetable extracts, essential oils, and their main constituents are active on the Central Nervous System (CNS). In fact, they have been used as sedatives, hypnotics, or tranquilizers for their activity in treating CNS disorders. In this research, we studied the possible activities of Lavandula angustifolia (LA) essential oil and of its main constituent, linalool, as anti-stress compounds on anxiety and social interaction and their in vitro effects on proteins (pERK and PKA) involved in the transmission of the signal. An acute intraperitoneal injection of linalool (100 mg/kg) and of LA essential oil (200 mg/kg) reduced motor activity without any anxiolytic effect, but significantly increased social interaction. Stressed mice, after being exposed to a social defeat encounter, showed heightened anxiety and social avoidance. Acute administration of LA essential oil blocked stress-induced anxiety, while linalool showed no effects. However, both compounds were capable of reversing social aversion, acting as antidepressant agents. Our results showed that linalool inhibits pERK and PKA expression in the SH-SY5Y cell, but no effect was detected with the LA essential oil. Therefore, the LA essential oil and linalool may be considered as useful alternative tools to the available traditional treatments for social stress-induced mental illnesses.

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Comparison of the effect of lavender and bitter orange on anxiety in postmenopausal women: A triple-blind, randomized, controlled clinical trial

Cited by 39 publications

References 21 publications

Comparing the Aromatherapeutic Effects of Orange and Lavender Essential Oils on Anxiety and Physiological Indicators in Patients Undergoing Coronary Angiography: A Clinical Trial Study

Comparing the Aromatherapeutic Effects of Orange and Lavender Essential Oils on Anxiety and Physiological Indicators in Patients Undergoing Coronary Angiography: A Clinical Trial Study

Biological Activities and Safety of Citrus spp. Essential Oils

Lavandula angustifolia Essential Oil and Linalool Counteract Social Aversion Induced by Social Defeat

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