Comparison of the efficacy of narrow band ultraviolet B and narrow band ultraviolet B plus topical catalase-superoxide dismutase treatment in vitiligo patients

Critical appraisal of the oxidative stress pathway in vitiligo: a systematic review and meta‐analysis

“…Combinations of SOD with or without CAT and other additional compounds (vitamin B12, calcium pantothenate, copper, zinc) were tested in six trials (152 patients). Two studies were placebo controlled, and in one study, betamethasone 0.05% was used as a control . One report using excimer light with Vitiskin hydrogel (SOD, copper–zinc, vitamin B12, calcium pantothenate) did mention more repigmentation (>51% repigmentation in 47% vs. 0% with intra‐individual comparison) after 3 months of therapy while the results of another study using Vitix gel (SOD, CAT) were negative .…”

Vitiligo: A comprehensive overview

“…While one case study showed remarkable repigmentation response on the face and hands of patients using combination topical pseudocatalase/calcium with short-term UVB phototherapy, 125 other studies show no such benefit. 126,127 In patients undergoing Dead Sea climatotherapy (where the mineral content of the water and ozone composition allow maximum natural UV light exposure without phototoxicity), topical pseudocatalase was shown to initiate repigmentation after just 10 to 16 days, compared to the 5 to 14 weeks in those using either as monotherapy. 128 One study suggested that topical catalase/superoxide dismutase may be as effective as topical 0.05% betamethasone.…”

The effect of pseudocatalase/superoxide dismutase in the treatment of vitiligo: A pilot study

“…[12] In another study with two case and control groups, which used narrow band UVB and narrow band UVB plus topical catalase-SOD, no superiority of treatment with PSD was shown. [8]…”

“…Till now, many studies have been conducted to show the usefulness of this regime, although some of which failed to show such result. [78910]…”