Comparison of the expression of ABH/Lewis‐related antigens in polypoid and non‐polypoid growth types of colorectal carcinoma

Nakagoe, Tohru; Fukushima, Kiyoyasu; Nanashima, Atsushi; Sawai, Terumitsu; Tsuji, Takashi; Jibiki, Masaaki; Yamaguchi, Hiroyuki; Yasutake, Toru; Ayabe, Hiroyoshi; Matuo, Tatsuki; Tagawa, Yutaka

doi:10.1046/j.1440-1746.2001.02425.x

Cited by 14 publications

(11 citation statements)

References 32 publications

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“…The absence of an association between anatomoclinical parameters, ABO antigen expression, and cancer was also observed in previous studies in addition to the present one [32][33][34]. Few studies have evaluated cancer and ABO genotyping, and in some tumors, alteration of ABO/Lewis-related antigens is associated with malignant transformations [35][36][37][38]. Blood group type O has been associated with well-differentiated tumors, while patients with esophageal carcinoma and AB blood type presented larger tumor sizes and more advanced TNM staging [39].…”

Section: Discussionsupporting

confidence: 79%

Polymorphisms of Lewis and Secretor genes are related to breast cancer and metastasis in axillary lymph nodes

et al. 2010

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ABH and Lewis antigen expression has been associated with cancer development and prognosis, tumor differentiation, and metastasis. Considering that invasive ductal breast carcinoma (IDC) presents multiple molecular alterations, the aim of the present study was to determine whether the polymorphism of ABO, Lewis, and Secretor genes, as well as ABO phenotyping, could be associated with tumor differentiation and lymph nodes metastasis. Seventy-six women with IDC and 78 healthy female blood donors were submitted to ABO phenotyping/genotyping and Lewis and Secretor genotyping. Phenotyping was performed by hemagglutination and genotyping by the polymerase chain reaction with sequence-specific primers. ABO, Lewis, and Secretor genes were classified by individual single nucleotide polymorphism at sites 59, 1067, 202, and 314 of the Lewis gene, 428 of the Secretor gene, and 261 (O1 allele), 526 (O2 and B allele), and 703 (B allele). No association was found between breast cancer and ABO antigen expression (P = 0.9323) or genotype (P = 0.9356). Lewis-negative genotype was associated with IDC (P = 0.0126) but not with anatomoclinical parameters. Nonsecretor genotype was associated with axillary lymph node metastasis (P = 0.0149). In conclusion, Lewis and Secretor genotyping could be useful to predict respectively breast cancer susceptibility and axillary lymph nodes metastasis.

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Section: Discussionsupporting

confidence: 79%

Polymorphisms of Lewis and Secretor genes are related to breast cancer and metastasis in axillary lymph nodes

et al. 2010

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“…One study evaluating normal penile skin compared to squamous cell carcinoma showed less A antigen expression in SCC compared to normal skin [12], which is consistent with our finding that A blood type was less common in SCC cases. Other studies have shown that ABO blood group antigen expression in tumors is associated with metastasis and prognosis [8], [13], [14], [15]. Hence, several plausible mechanisms, including inflammation, immunosurveillance for malignant cells, intercellular adhesion, and membrane signaling have been proposed to explain the observed association between ABO blood groups and cancer risk [7].…”

Section: Discussionmentioning

confidence: 96%

ABO Blood Group and Incidence of Skin Cancer

Xie

Qureshi

et al. 2010

PLoS ONE

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BackgroundPrevious studies have examined the association between ABO blood group and the risk of some malignancies. However, no prospective cohort study to date has examined the association between ABO blood group and the risk of skin cancer.Methodology/Principal FindingsUsing two large cohorts in the US, we examined ABO blood type and incidence of skin cancer, including melanoma, squamous cell carcinoma (SCC), and basal cell carcinoma (BCC). We followed up study participants (70,650 female nurses and 24,820 male health professionals) on their diagnosis of incident skin cancer from cohort baseline (1976 in women and 1986 in men) until 2006. Study participants reported their blood type in 1996 in both cohorts. During the follow-up, 685 participants developed melanoma, 1,533 developed SCC and 19,860 developed BCC. We used Cox proportional hazards models to calculate the hazard ratios (HR) and 95% confidence intervals (CI) of each type of skin cancer. We observed that non-O blood group (A, AB, and B combined) was significantly associated with a decreased risk of non-melanoma skin cancer overall. Compared to participants with blood group O, participants with non-O blood group had a 14% decreased risk of developing SCC (multivariable HR: 0.86; 95% CI: 0.78, 0.95) and a 4% decreased risk of developing BCC (multivariable HR: 0.96; 95% CI: 0.93, 0.99). The decreased risk of melanoma for non-O blood group was not statistically significant (multivariable HR: 0.91; 95% CI: 0.78, 1.05).Conclusion/SignificanceIn two large independent populations, non-O blood group was associated with a decreased risk of skin cancer. The association was statistically significant for non-melanoma skin cancer. Additional studies are needed to confirm these associations and to define the mechanisms by which ABO blood type or closely linked genetic variants may influence skin cancer risk.

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“…Alteration of ABO/Lewis antigen is associated with malignant transformation in some neoplasm. Nakagoe et al (2001) examined immunohistochemically the expression of blood group ABO isoantigens and Lewis related carbohydrate antigens compared according to cellular characteristics of tumor. Their study revealed that isoantigen A and siayl Lex were associated with nonpolypoid growth-type (NPG-type) tumors and these tumors were more likely to develop lymph node metastases (Nakagoe et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

“…Such a significant relationship hasn't been identified for CRC (Aird et al, 1954;Khalili et al, 2011). Various cancer cells express blood group antigens on cell surface and in several studies cancer associated alterations of ABO antigen expression in human colon cancer tissues have been reported (Schoentag et al, 1987;Dabelsteen et al, 1988;Dahiya et al, 1989;Nakagoe et al, 2001). However the correlation of ABO antigen expression either on erythrocyte or tumor cell, and genetic factors in CRC patients has not been studied yet.…”

Section: Introductionmentioning

confidence: 99%

ABO and Rh Blood Groups and Risk of Colorectal Adenocarcinoma

Ürün¹,

Özdemir²,

Utkan³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Background: Previous studies have observed an association between ABO blood group and risk for certain gastrointestinal malignancies, including pancreatic and gastric cancer. However, it is unclear whether there is such an association with colorectal cancer (CRC). In this study, possible relationships between ABO blood groups and Rh factor and KRAS status in patients with CRC were investigated. Materials and Methods: In 1,620 patients with CRC, blood group and Rh factor were examined and compared with the control group of 3,022,883 healthy volunteer blood donors of the Turkish Red Crescent between 2004 and 2011. The relationship of blood groups with wild type K-ras status was also evaluated. Results: Overall distributions of ABO blood groups as well as Rh factor were comparable between patients (45% A, 7.2% AB, 16.4% B, 31.4% O, and 87.2% Rh+) and controls (42.2% A, 7.6% AB, 16.3% B, 33.9% O, and 87.7% Rh+) (p=0.099). However, there were statistically significant difference between patients and controls with respect to O vs. non O blood group (p=0.033) and marginally significant difference for A vs. non-A blood group (p=0.052). Among patients, the median age was 62 (range 17-97), 58.1% were male. There were no statistically significant differences respect to sex and K-ras status. Conclusion: In present study, the ABO/Rh blood groups were statistically significantly associated with the risk of CRC. There were no relationship between K-ras status and ABO blood group and Rh factor. However further studies with larger numbers of patients are needed to establish the role of blood groups and to define the mechanisms by which ABO blood type affect CRC.

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Comparison of the expression of ABH/Lewis‐related antigens in polypoid and non‐polypoid growth types of colorectal carcinoma

Abstract: These data suggest that the expression of isoantigen A and sialyl Le(x) in a colorectal carcinoma partially determines whether the tumor will have polypoid or non-polypoid growth.

Cited by 14 publications

References 32 publications

Polymorphisms of Lewis and Secretor genes are related to breast cancer and metastasis in axillary lymph nodes

Polymorphisms of Lewis and Secretor genes are related to breast cancer and metastasis in axillary lymph nodes

ABO Blood Group and Incidence of Skin Cancer

ABO and Rh Blood Groups and Risk of Colorectal Adenocarcinoma

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