Comparison of the in vitro activity of linezolid, tedizolid, sutezolid, and delpazolid against rapidly growing mycobacteria isolated in Beijing, China

Abstract

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In vitro Susceptibility of Nontuberculous Mycobacteria to Tedizolid

“… 15 However, a previous study from Beijing, China, showed high-level MIC values to TZD, in which the TZD MIC 50 and MIC 90 for M. avium and M. intracellulare were 32 and >32 μg/mL, respectively. 23 Therefore, the relative higher MIC values for MAC isolates in our study could have national and geographical reasons such as the high use of antibiotics in China. Furthermore, all studies including ours showed the high MIC values of TZD against MAC; thus, it is necessary to carry out drug sensitivity tests before TZD administration.…”

“…This result is consistent with previous studies in which the TZD MIC 50 and MIC 90 were 1-4 and 2-8 μg/mL, respectively. 13,15,[21][22][23] The TZD MIC 50 and MIC 90 for MAC were relatively high at 16 and 32 μg/mL, respectively (Table 2). In a previous study, both the TZD MIC 50 and MIC 90 for MAC were 8 μg/mL.…”

Inhibition of chloroplast translation as a new target for herbicides

“…This efficiency was less than, but comparable to the commercial herbicide asulam that was lethal at all concentrations tested pre-and post-emergence. Sutezolid 2, a thiomorpholine analogue of linezolid with similar antimicrobial effects, 39 had activity similar to 1. By contrast for 1 and 2, the piperazyl analogue 3 of 1 was inactive (Fig.…”

In vitro Antimicrobial Activity Comparison of Linezolid, Tedizolid, Sutezolid and Delpazolid Against Slowly Growing Mycobacteria Isolated in Beijing, China

“… 1 , 19 Our previous study showed that TZD harbors the strongest inhibitory activity against M. abscessus in vitro, while DZD offered the best inhibitory activity against M. fortuitum in vitro. 20 Furthermore, TZD could inhibit the intracellular bacterial population of both M. avium and M. abscessus and had a concentration-dependent synergistic effect against amikacin and ethambutol. 21 Since these new oxazolidinone drugs are currently not in clinical usage or have been recently adopted, therefore, well-recognized susceptibility testing methods for TZD, SZD and DTD have not been developed.…”