Comparison of therapeutic effects of conventional and liposomal form of 4% topical hydroquinone in patients with melasma

Taghavi, Faezeh; Banihashemi, Mahnaz; Zabolinejad, Nona; Salehi, Maryam; Jaafari, Mahmoud Reza; Marhamati, Hoda; Golnouri, Faeze; Dorri, Mahyar

doi:10.1111/jocd.12744

Cited by 15 publications

(5 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The patients were randomly allocated to the conventional hydroquinone 4% and liposomal hydroquinone 4% groups and the melasma severity was assessed through the MASI score at defined time points. The findings of the study indicated that although the liposomal hydroquinone 4% was efficient in melasma management and could induce a significant reduction in MASI score, however, no superiority was obvious in comparison to the conventional hydroquinone cream ( Taghavi et al, 2019a ).…”

Section: Clinical Outcomes Of Pharmacotherapymentioning

confidence: 83%

“…The obtained MASI scores from this plot study indicated appreciable therapeutic effectiveness of liposomal hydroquinone in comparison to the conventional hydroquinone cream ( Banihashemi et al, 2015a ). Results of another study indicated that although the therapeutic effect of hydroquinone in melasma treatment was preserved after encapsulation in liposomes, however, no significant superiority was observed in comparison to the conventional cream ( Taghavi et al, 2019b ).…”

Section: New Approaches In Melasma Pharmacotherapymentioning

confidence: 99%

See 1 more Smart Citation

Different therapeutic approaches in melasma: advances and limitations

Ghasemiyeh,

Fazlinejad,

Kiafar

et al. 2024

Front. Pharmacol.

View full text Add to dashboard Cite

Melasma is a chronic hyperpigmentation skin disorder that is more common in the female gender. Although melasma is a multifactorial skin disorder, however, sun-exposure and genetic predisposition are considered as the main etiologic factors in melasma occurrence. Although numerous topical and systemic therapeutic agents and also non-pharmacologic procedural treatments have been considered in melasma management, however, the commonly available therapeutic options have several limitations including the lack of sufficient clinical effectiveness, risk of relapse, and high rate of unwanted adverse drug reactions. Recruitment of nanotechnology for topical drug delivery in melasma management can lead to enhanced skin penetration, targeted drug delivery to the site of action, longer deposition at the targeted area, and limit systemic absorption and therefore systemic availability and adverse drug reactions. In the current review, first of all, the etiology, pathophysiology, and severity classification of melasma have been considered. Then, various pharmacologic and procedural therapeutic options in melasma treatment have been discussed. Afterward, the usage of various types of nanoparticles for the purpose of topical drug delivery for melasma management was considered. In the end, numerous clinical studies and controlled clinical trials on the assessment of the effectiveness of these novel topical formulations in melasma management are summarized.

show abstract

Section: Clinical Outcomes Of Pharmacotherapymentioning

confidence: 83%

Section: New Approaches In Melasma Pharmacotherapymentioning

confidence: 99%

Different therapeutic approaches in melasma: advances and limitations

Ghasemiyeh,

Fazlinejad,

Kiafar

et al. 2024

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…Multiple RCTs have been conducted, comparing HQ creams (of different percentages) with several topical agents, and variable results have been reported. [ 33 34 35 36 37 38 39 40 41 42 43 44 ] HQ is one of the most effective therapies for melasma, when compared with other agents. However, TCCs and 3% Rumex occidentalis (RO) cream score higher when a head-to-head comparison is performed.…”

Section: Discussionmentioning

confidence: 99%

“…It is worth mentioning that liposomal HQ cream was not found to be better than the conventional HQ cream, in terms of effectiveness in an Iranian RCT published in 2019. [ 41 ]…”

Section: Discussionmentioning

confidence: 99%

Topical and Systemic Therapies in Melasma: A Systematic Review

Sarkar,

Handog,

Das

et al. 2023

Indian Dermatology Online Journal

View full text Add to dashboard Cite

Introduction: Melasma is an acquired disorder, which presents with well-demarcated, brown-colored hyperpigmented macules, commonly involving the sun-exposed areas such as the face. It is a chronic and distressing condition, affecting the patients' quality of life, and has been conventionally treated with “first-line” agents including hydroquinone (HQ) alone or as a part of a triple combination cream (TCC), while “second-line” options include chemical peels, and third line options include laser therapy. Materials and Methods: A systematic search was performed for all topical and systemic treatments for melasma up till May 4, 2021, using the PubMed and EMBASE databases, according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol. The search terms “melasma” and “treatment” were used to search for the relevant articles on both these databases, and a total of 4020 articles were identified. After removing the duplicate entries and screening the titles, abstracts, and full-text articles, we identified 174 randomized controlled trials (RCTs) or controlled clinical trials. Results: Based on our review, HQ, TCCs, sunscreens, kojic acid (KA), and azelaic acid receive grade A recommendation. Further large-scale studies are required to clearly establish the efficacy of topical vitamin C, resorcinol, and topical tranexamic acid (TXA). Several newer topical agents may play a role only as an add-on or second-line drugs or as maintenance therapy. Oral TXA has a strong recommendation, provided there are no contraindications. Procyanidins, Polypodium leucotomos (PL), and even synbiotics may be taken as adjuncts. Discussion: Several newer topical and systemic agents with multimodal mechanisms of action have now become available, and the balance seems to be tipping in favor of these innovative modalities. However, it is worth mentioning that the choice of agent should be individualized and subject to availability in a particular country.

show abstract

“…La HQ tópica sigue siendo el tratamiento más estudiado, por su excelente perfil de seguridad y efectividad, en el tratamiento del melasma. El estudio de Taghavi et al [19] mostró que la HQ en fórmula liposomal es igual de efectiva que la fórmula tradicional, aunque presenta menos efectos secundarios sobre la piel. La triple terapia combinada (TCC) continúa siendo el tratamiento más efectivo, aunque se han estudiado múltiples variaciones de su formulación original para disminuir los efectos adversos.…”

Section: Discussionunclassified

Actualización en el tratamiento del melasma. Revisión sistemática

López¹,

Egea²

2021

Medicina Estética

View full text Add to dashboard Cite

"Introducción. El melasma es una alteración en la melanogénesis de predominio facial que produce manchas de coloración marrón. Suele afectar a las mujeres. Su origen es multifactorial y está íntimamente relacionado con el estado hormonal y la exposición solar. Estas lesiones tienen un gran impacto sobre la calidad de vida de los pacientes, por lo que se han realizado múltiples estudios para dilucidar qué tratamientos son los más adecuados. El objetivo principal es evaluar la eficacia de los diferentes tratamientos en el melasma. Material y método. Revisión sistemática de artículos completos de enero de 2019 a junio de 2020, basados en estudios clínicos originales obtenidos de las bases de datos PubMed (Medline) y Cercabib. Se revisaron ensayos clínicos de enero de 2016 a diciembre de 2018 para encontrar publicaciones que, aun siendo menos actualizadas, pudieran aportar un conocimiento adicional. También se consultaron los resúmenes de estudios clínicos y metaanálisis de los últimos 5 años para desarrollar los apartados de introducción y discusión del estudio. Resultados. Se incluyeron 19 ensayos clínicos y 2 metaanálisis: 4 de tratamientos tópicos, 6 sobre ácido tranexámico, 4 de exfoliaciones, 6 de tratamiento con láseres y 1 sobre fotoprotección. Conclusiones. La hidroquinona sigue siendo el gold standard para el tratamiento del melasma. En los últimos años se ha evidenciado la efectividad del ácido tranexámico como opción terapéutica. La fotoprotección es fundamental en el control de esta patología. El empleo de peelings superficiales y dispositivos láser debe valorarse cuidadosamente."

show abstract

Comparison of therapeutic effects of conventional and liposomal form of 4% topical hydroquinone in patients with melasma

Abstract: This study shows that liposomal hydroquinone has a significant therapeutic effect on melasma, but we did not observe any superiority in comparison with the conventional method. Therefore, it can be considered in the treatment protocol of this disease.

Cited by 15 publications

References 8 publications

Different therapeutic approaches in melasma: advances and limitations

Different therapeutic approaches in melasma: advances and limitations

Topical and Systemic Therapies in Melasma: A Systematic Review

Actualización en el tratamiento del melasma. Revisión sistemática

Contact Info

Product

Resources

About