Comparison of three short-term assays: results on seven chemicals

Curieux, Frank Le; Marzin, Daniel; Erb, F.

doi:10.1016/0165-1218(93)90082-o

Cited by 35 publications

(14 citation statements)

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“…The dose-response relationship with an increase of β-galactosidase syntheses induction and decrease in alkaline phosphatase activity has been detected before for formaldehyde at 20-50 μg ml , in SOS chromotest using PQ37 strain (Le Curieux et al, 1993). In our results, an eff ect on SOS induction by HC-2 sample was detected on uvrA and oxyR4 strains, which have defective DNA repair.…”

Section: Discussionsupporting

confidence: 50%

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Mutagenic risks induced by homemade hair straightening creams with high formaldehyde content

Mazzei

Figueiredo

Veiga

et al. 2009

J of Applied Toxicology

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Regardless of official recommendations, the inappropriate use of homemade hair creams has became a popular practice in Brazil and high formaldehyde content in the 'progressive straightening' creams has been reported. In the present work, three of these creams were analyzed by spectrophotometric, chromatographic and genotoxic assays in order to evaluate mutagenic risks associated with the uncontrolled addition of formaldehyde at contents higher than those allowed by regulation. The ultraviolet and Fourier-transformed infrared absorption spectra showed characteristic signals that can be assigned to formaldehyde, although with different relative intensities, revealing distinct compositions. Using high-performance liquid chromatography 1.6-10.5% w/v formaldehyde was quantified. Antibacterial activity was detected in all creams. At 0.10 microg per plate, one of them showed positive mutagenicity induction (P < 0.05) in the Salmonella/microsome assay using the TA100 strain. The measurement of beta-galactosidase induction in the SOS chromotest by this cream, at dosages of 10-100 microg per assay, was positive (P < 0.05) in Escherichia coli PQ37 and OG100 strains. Our data show a more intense genotoxic response than those reported before for formaldehyde, suggesting that this compound may be acting synergistically with any unknown components in the creams or perhaps these unspecified components by themselves might have significant genotoxic potential. We call attention to the popular use of homemade formulations of cosmetics, such as hair straightening creams, because they can contain mutagens that could increase the incidence of neoplasia in those people who use them.

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Section: Discussionsupporting

confidence: 50%

“…A clear mutagenicity of formaldehyde has been demonstrated before (Le Curieux et al, 1993;NIEHS, 2002) for S. typhimurium TA97, TA100, TA102 and TA104 strains. By a rough linear regression from the data found in Table 2, HC-2 seems to have produced around 800 revertants μg −1 .…”

Section: Discussionmentioning

confidence: 91%

Mutagenic risks induced by homemade hair straightening creams with high formaldehyde content

Mazzei

Figueiredo

Veiga

et al. 2009

J of Applied Toxicology

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“…Sodium hypochlorite has been found to be mutagenic in Salmonella typhimurium TA1530 and TA100 but not TA1538 (Wlodkowski and Rosenkranz 1975;Ishidate et al 1984). On the other hand, Le Curieux et al (1993) did not detect any significant mutagenic activity on TA100, TA102, and TA98 strains. In mammals, sodium hypochlorite produced chromosomal aberrations in Chinese hamster fibroblast cells without metabolic activation (Ishidate et al 1984).…”

Section: Introductionmentioning

confidence: 87%

“…Hypochlorite ions and hypochlorous acid were negative in the in vivo erythrocyte micronucleus assay and in bone marrow aberration studies in mice (Meier et al 1985). Buschini et al (2004) reported sodium hypochlorite effects on Saccharomyces cerevisiae without endogenous metabolic activation whereas a clastogenic effect was detected by the newt micronucleus assay, a sensitive method for testing promutagens (Le Curieux et al 1993).…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic and genotoxic effects of sodium hypochlorite on human peripheral lymphocytes in vitro

2009

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Chlorination is widely used method in the disinfection of drinking and utility water worldwide. In this study, cytotoxic and genotoxic effects of sodium hypochlorite were investigated by the cytokinesis-block micronucleus assay and chromosomal aberration analysis on human peripheral lymphocytes in vitro. A significant increase in chromosomal aberration frequency was observed in all treatments of NaOCl (0.030, 0.065, 0.100, 0.25, 0.5, 1, 2, 4 lg/mL) at 24 and 48 h compared with the negative control and mitomycin C (MMC, 0.3 lg/mL), which was used as a positive control. NaOCl significantly increased the frequency of micronuclei in a dose dependent manner. The results showed that there was a significant correlation between NaOCl concentration and chromosomal aberration, micronuclei frequency, necrotic cells, apoptotic cells and binucleated cells.

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“…Formaldehyde caused mutagenic activity in Salmonella typhimurium TA102 and TA1535, but acetaldehyde and acrolein did not (Flora et al, 1984;Marnett et al, 1985;Curieux et al, 1993;Temcharoen and Thilly, 1983).…”

mentioning

confidence: 99%

Mutagenic Activity of Incense Smoke in Comparison to Formaldehyde and Acetaldehyde in Salmonella typhimurium TA102

Chang

Kuo

Lin

1997

Bulletin of Environmental Contamination and Toxicology

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Comparison of three short-term assays: results on seven chemicals

Cited by 35 publications

References 50 publications

Mutagenic risks induced by homemade hair straightening creams with high formaldehyde content

Mutagenic risks induced by homemade hair straightening creams with high formaldehyde content

Cytotoxic and genotoxic effects of sodium hypochlorite on human peripheral lymphocytes in vitro

Mutagenic Activity of Incense Smoke in Comparison to Formaldehyde and Acetaldehyde in Salmonella typhimurium TA102

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