Comparison of Total Antioxidant Capacity and Vitamin C in Smokers and Non-smokers

Falsafi, Parisa; Nasrabadi, Elnaz Tayefi; Nasrabadi, Hamid Tayefi; Khiyavi, Reza Khorshidi; Eslami, Hosein

doi:10.13005/bpj/939

Cited by 7 publications

(8 citation statements)

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“…It also contains cytokines, buffers, immunoglobulins, enzymes, growth factors, Mosin and other host glycoproteins as well as defense systems such as antioxidant defense system that serves as the first line of defense against oxidative stress. [10] In the present study, reduction of total antioxidant capacity was observed in two groups of normal smokers and heavy smokers, compared to non-smokers, but this difference was not significant. Similar studies indicated contradictory results.…”

Section: Discussioncontrasting

confidence: 66%

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Comparison of total antioxidant capacity of saliva in men based on daily cigarette consumption

Pashaei

Alizadeh

Piri

et al. 2020

BDS

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Objective: Antioxidants play an important role in inhibiting free oxygen and nitrogen radicals and preventing their formation. There are contradictory results regarding the relationship between cigarette smoking and total antioxidant capacity of saliva. In this study, the total antioxidant capacity of saliva has been compared in normal smokers, heavy smokers and non-smokers. Material and methods: In this cross-sectional study, 28 heavy male smokers (more than one pack of cigarettes per day), 28 normal male smokers (less than one pack of cigarettes per day), and 28 male non-smokers aged 25 to 40 years old entered the study. Unstimulated saliva was collected by Spitting method. The total antioxidant capacity of saliva was measured using Ferric Reducing Antioxidant Power Assay. Descriptive statistics, ANOVA, and Tukey tests were used to analyze the data. Results: The mean total antioxidant capacity of saliva in male non-smokers was 0.0598 ± 0.08 ?mol / L, in normal male smokers was 0.049 ± 0.04 ?mol / L, and in heavy male smokers was 0.0388 ± 0.035 ?mol / L, which did not show any significant difference between the groups (P > 0.05). Conclusion: The results of this study indicate that smoking does not have a significant effect on total antioxidant capacity of saliva in smokers. KEYWORDS Smokers; Saliva; Total antioxidant capacity.

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Section: Discussioncontrasting

confidence: 66%

“…In the study of Falsafi et al [10], in which the antioxidant capacity of smokers and nonsmokers was examined, there was a significant difference, which was more among nonsmokers. The study by Eizadi et al [11] showed that total antioxidant capacity in smokers was significantly higher than non-smokers.…”

Section: O R I G I N a L A R T I C L Ementioning

confidence: 96%

Comparison of total antioxidant capacity of saliva in men based on daily cigarette consumption

Pashaei

Alizadeh

Piri

et al. 2020

BDS

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“…A large panel of papers evaluating the antioxidant capacity of smokers' saliva is available. The results of most studies clearly indicate that smoking cigarettes is accompanied by decreased activity of endogenous salivary enzymatic antioxidants such as SOD, CAT and Px as well as reduced concentration of non-enzymatic endo-and exoantioxidants: GSH, UA (Nagler) and vitamin C (Klein et al, 2003;Reznick et al, 2003;Nagler, 2007;Abdolsamadi et al, 2011;Falsafi et al, 2016;Arbabi-Kalati et al, 2017;Singh et al, 2018). According to the available evidence, cigarette smoke disturbs the metabolism of trace elements which are cofactors of antioxidant enzymes (copper and zinc as cofactors of SOD, iron as cofactor of CAT), thus reducing their activity (Nobari et al, 2021).…”

Section: Cigarette Addiction and Oral Healthmentioning

confidence: 99%

Ethanol- and Cigarette Smoke-Related Alternations in Oral Redox Homeostasis

2022

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Alcohol abuse as well as smoking cigarettes has been proven to negatively affect the oral environment. The aim of this work was to provide a systematic review of the literature on the influence of ethanol and cigarette smoking on oral redox homeostasis. A search was performed for scientific articles indexed in the PubMed, Medline and Web of Science databases. We identified 32,300 articles, of which 54 were used for the final review, including the results from 2000 to 2021. Among the publications used to write this article, n = 14 were related to the influence of alcohol consumption (clinical studies n = 6, experimental studies n = 8) and n = 40 were related to the influence of smoking (clinical studies n = 33, experimental studies n = 7) on oral redox homeostasis. The reviewed literature indicates that alcohol abusers and smokers are more likely to suffer from salivary gland dysfunction, as well as develop precancerous lesions due to DNA damage. Compared to alcohol abstainers and non-smokers, alcohol drinkers and smokers are also characterized by a deterioration in periodontal health measured by various indicators of periodontal status. In summary, alcohol abuse and smoking are associated with disrupted oral redox homeostasis, which may lead not only to tooth loss, but also contribute to various adverse effects related to mental health, digestive processes and chronic inflammation throughout the human body.

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“…The participants were asked not to eat, brush their teeth, use mouth rinse, or smoke at least two hours prior to sample collection. Each participant was asked to swallow, then tilt their head forward, and expectorate 10 ml of unstimulated whole saliva into a sterile centrifuge tube (13) .…”

Section: Salivary Sample Collectionmentioning

confidence: 99%

“…Various salivary biomarkers were investigated including cotinine, thiocyanate, nicotine, carbon monoxide, oxidants and anti-oxidants. Some of them proved to be specific to smoking only and others not, in addition most of them are not markers for oral cancer (9)(10)(11)(12)(13) .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Salivary Level of Mir-21 in Cigarette Smokers: Case-Control Study

Ali

Amer

2017

Egyptian Dental Journal

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Background: Salivary biomarkers are attractive non-invasive tools for screening oral cancer especially in high risk individuals such as smokers. The present study observed the salivary level of microRNA-21 to verify their value as diagnostic marker for smokers. Methods:The study sample comprised 40 males: 20 non-smokers and 20 smokers. Whole unstimulated saliva samples were collected. The resulting data was analyzed for any statistical significance. Results:Smokers had statistically significant higher salivary microRNA-21 level than nonsmokers. Conclusions:Our study demonstrated elevated levels of salivary microRNA-21 in cigarette smokers. Salivary miR-21 could be a promising new diagnostic marker for cigarette smokers. We recommend conducting further studies to investigate its diagnostic value as a marker for oral cancer susceptibility in cigarette smokers.

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Comparison of Total Antioxidant Capacity and Vitamin C in Smokers and Non-smokers

Cited by 7 publications

References 0 publications

Comparison of total antioxidant capacity of saliva in men based on daily cigarette consumption

Comparison of total antioxidant capacity of saliva in men based on daily cigarette consumption

Ethanol- and Cigarette Smoke-Related Alternations in Oral Redox Homeostasis

Evaluation of the Salivary Level of Mir-21 in Cigarette Smokers: Case-Control Study

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