Comparison of tumour necrosis factor and endothelin-1 between essential and renal hypertensive patients

Cottone, Santina; Vadalà, Anna; Vella, M.C.; Mulè, Giuseppe; Contorno, A; Cerasola, Giovanni

doi:10.1038/sj.jhh.1000596

Cited by 23 publications

(20 citation statements)

References 23 publications

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“…5,6 Some reports 3,4,7 have shown a significant association between inflammatory markers and elevated BP, consistent with our findings. Kim et al 8 reported that TNF-a level correlated with the BP index and IL-6 level correlated with the BP variability index, implying that inflammation may be a mediator for the link between BP variability and target organ damage.…”

Section: Discussionsupporting

confidence: 82%

Correlation of tumor necrosis factor alpha and interleukin 6 with hypertensive renal damage

Yang

2010

Renal Failure

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Background: Many efforts have been made to investigate the role played by cytokines in the development of hypertension. But few reports exist on the association between cytokines and hypertensive renal damage. This study was to observe the changes of the serum levels of cytokines, tumor necrosis factor alpha (TNF-a), and interleukin 6 (IL-6) in patients with hypertensive renal damage, whereby to study the correlation of TNF-a and IL-6 with the hypertensive renal damage. Methods: According to their urinary albumin excretion rate (UAER), 102 patients with essential hypertension were divided into three groups: normoalbuminuria hypertensive group (n = 37), microalbuminuria hypertensive group (n = 36), and proteinuric hypertensive group (n = 29). Serum TNF-a and IL-6 of all subjects were measured with radioimmune assay. Thirty age-and gendermatched normotensive persons were selected as normotensive control group. Results: Serum levels of TNF-a and IL-6 were significantly higher in patients with essential hypertension than those in normotensive control group (p < 0.5). Serum levels of TNF-a and IL-6 increased in proportion to UAER. The statistical significance was present among groups (p < 0.05). Both TNF-a and IL-6 were found to have a positive correlation with UAER (r = 0.79, p < 0.01; r = 0.75, p < 0.01), but not with the levels of blood pressure (BP). Conclusions: TNF-a and IL-6 are remarkably increased in hypertensive patients and may play an important role in the pathogenesis and the development of hypertensive renal damage.

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Section: Discussionsupporting

confidence: 82%

Correlation of tumor necrosis factor alpha and interleukin 6 with hypertensive renal damage

Yang

2010

Renal Failure

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“…(2) Hypertension is a major risk factor for cardiovascular disease and experimental evidence suggests that it may be an inflammatory stimulus which can promote expression of cytokines. (3)(4)(5)(6) A recent report has demonstrated a graded relationship between blood pressure and indices of inflammation, particularly interleukin-6, in apparently healthy men strengthening the postulated link between elevated blood pressure and inflammation. (7) The development of left ventricular hypertrophy (LVH) in hypertensive patients is an important negative prognostic sign associated with cardiovascular morbidity and mortality.…”

Section: Introductionmentioning

confidence: 95%

Tumor necrosis factor and interleukin‐6 levels in hypertensive patients with and without left ventricular hypertrophy

Leibowitz¹,

Planer²,

Ben‐ivgi³

et al. 2005

Blood Pressure

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The objective of this prospective study was to examine the association between serum levels of TNF (tumor-necrosis factor) and IL-6 (interleukin-6) and left ventricular mass in hypertensive patients. Hypertensive patients currently receiving medical therapy were eligible. All subjects underwent echocardiography with measurements of left ventricular (LV) mass and ejection fraction (EF) and had serum levels of TNF and IL-6 measured by ELISA immunoassay. 35 subjects (20F, 15M; mean age 56.4 +/- 10.5 yrs) were studied. 19 patients (54%) had elevated LV mass. Of these patients, 6 (32%) had detectable serum TNF levels and 1 (7%) had detectable IL-6 levels, (p = NS). Hypertensive patients with elevated LV mass do not consistently exhibit elevated cytokine levels when compared to those with normal LV mass.

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“…Cytokines appear to be important mediators of renal injury and the development of LVH. As noted, aging is associated with increased vascular stiffness and hypertension; and in particular, those with renal insufficiency have elevated levels of tumor necrosis factor [28]. In addition, studies have shown that elevated C-reactive protein levels in CKD patients were independent predictors of increased LV mass [29].…”

Section: Inflammationmentioning

confidence: 99%

Left Ventricular Hypertrophy and Chronic Renal Insufficiency in the Elderly

Leibowitz

2014

Cardiorenal Med

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Background: The global population is aging. Cardiovascular disease is the leading cause of death in both men and women older than 65 years. In particular, elderly patients have an increased prevalence of left ventricular hypertrophy (LVH) and chronic kidney disease (CKD), both of which predict increased cardiovascular morbidity and mortality. LVH and CKD frequently coexist in the elderly, and LVH is a powerful predictor of mortality in patients with end-stage renal disease. Key Messages: Several hemodynamic factors contribute to LVH and CKD in the elderly. Increased arterial stiffness in the elderly is associated with LVH and CKD. Studies using noninvasive measures of arterial stiffening have shown a correlation between these measures and LVH in patients with CKD. Hypertensive patients with an altered circadian blood pressure pattern such as nondippers have an increased incidence of LVH and CKD. Anemia is a risk factor for LVH in patients in all stages of CKD, and studies have shown correlations between age, anemia and LV mass. Nonhemodynamic factors include chronic inflammation, increased oxidative stress, and reduced autophagy, all of which are present in the elderly. Disordered mineral metabolism in the elderly with reduced levels of vitamin D and elevated levels of parathyroid hormone and phosphorus is associated with LVH and CKD. Conclusions: Multiple pathophysiologic mechanisms contribute to the development of LVH and CKD in the elderly. Future research should be directed at interfering with this development and reducing the burden of cardiovascular and renal diseases in this growing population. i 2014 S. Karger AG, Basel

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Comparison of tumour necrosis factor and endothelin-1 between essential and renal hypertensive patients

Cited by 23 publications

References 23 publications

Correlation of tumor necrosis factor alpha and interleukin 6 with hypertensive renal damage

Correlation of tumor necrosis factor alpha and interleukin 6 with hypertensive renal damage

Tumor necrosis factor and interleukin‐6 levels in hypertensive patients with and without left ventricular hypertrophy

Left Ventricular Hypertrophy and Chronic Renal Insufficiency in the Elderly

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