Comparison of ultrasonography and histologic examination for identification of ocular diseases of animals: 113 cases (2000–2010)

Gallhoefer, Nicolin S.; Bentley, Ellison; Ruetten, Maja; Grest, Paula; Haessig, Michael; Kircher, Patrick R.; Dubielzig, Richard R.; Spiess, Bernhard M.; Pot, Simon A.

doi:10.2460/javma.243.3.376

Cited by 22 publications

(20 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Conventional ultrasonography is frequently required to evaluate intraocular and retrobulbar pathologies, although its accuracy varies among diseases . B‐mode and Doppler techniques may be at risk of misdiagnoses and artifacts . Computed tomography (CT) in dogs is often limited to differentiation of neoplastic vs nonneoplastic lesions .…”

Section: Discussionmentioning

confidence: 99%

Quantitative, noninvasive assessment of intra‐ and extraocular perfusion by contrast‐enhanced ultrasonography and its clinical applicability in healthy dogs

Blohm

Hittmair

Tichy

et al. 2019

Veterinary Ophthalmology

View full text Add to dashboard Cite

ObjectiveTo assess quantitative perfusion of intra‐ and extraocular regions of interest (ROIs) in conscious, healthy dogs utilizing contrast‐enhanced ultrasonography (CEUS); to compare varying enhancement with the first and second bolus injection and in the right and left eye; and to determine the most appropriate examination time.ProceduresGray scale ultrasonography and contrast harmonic imaging using sulfur hexafluoride were performed randomly assigned in both eyes in 10 university‐owned beagles. Perfusion parameters including slope time, time to peak (TTP), peak intensity (PI), and area under the curve (AUC) were measured at individually drawn ROIs (retrobulbar cone = ROI 1, choroid‐retina complex = ROI 2, medial = ROI 3, and lateral anterior uvea = ROI 4).ResultsTime‐intensity curve parameters revealed no significant differences in eyes examined by the first or second bolus injection (P > 0.05) or in the right or left eye (P > 0.05). Pooled data from all eyes were analyzed. Peak intensity of ROI 2 was significantly higher compared to all other ROIs (P < 0.001). Area under the curve at ROI 2 was significantly higher compared to all other ROIs (P < 0.05), and AUC at ROI 1 was significantly higher than at ROI 4 (P < 0.05). No significant differences in TTP were observed between different ROIs (P > 0.05). Ratios relative to different ROI sizes showed fastest enhancement in the retrobulbar cone and most intense perfusion in the anterior uveal regions. The first minute after contrast injection provided the highest diagnostic value.ConclusionQuantitative perfusion in nondiseased canine eyes revealed consistent parameters. Application of standardized CEUS protocols may be a promising diagnostic tool to differentiate ocular lesions.

show abstract

Section: Discussionmentioning

confidence: 99%

Quantitative, noninvasive assessment of intra‐ and extraocular perfusion by contrast‐enhanced ultrasonography and its clinical applicability in healthy dogs

Blohm

Hittmair

Tichy

et al. 2019

Veterinary Ophthalmology

View full text Add to dashboard Cite

show abstract

“…Analysis of the final diagnosis showed that recurrent uveitis, keratitis/keratouveitis and corneal ulceration/perforation were the most common diseases affecting 33, 26 and 20 horses, respectively, according to the literature [1,[16][17][18][19].…”

Section: Discussionmentioning

confidence: 99%

A survey of ocular ultrasound abnormalities in horse: 145 cases

Gialletti

Marchegiani

Valeriani³

et al. 2018

J Ultrasound

View full text Add to dashboard Cite

show abstract

“…Globe rupture, lens luxation, lens rupture, retinal detachment, and retrobulbar lesions have been depicted by conventional ultrasonography. Despite being noninvasive, cost‐effective, and widely available, the B‐mode echogenicity is often equivocal which indicates extended modalities (Doppler and contrast imaging), providing additional information on blood flow and perfusion …”

Section: Introductionmentioning

confidence: 99%

“…lens rupture, 1,3 retinal detachment, [1][2][3][4] and retrobulbar lesions 1,3 have been depicted by conventional ultrasonography. Despite being noninvasive, cost-effective, and widely available, 3 the B-mode echogenicity is often equivocal 5 which indicates extended modalities (Doppler and contrast imaging), 6 providing additional information on blood flow and perfusion. [7][8][9] Contrast-enhanced ultrasonography (CEUS) proved its clinical value in eyes of humans, [10][11][12] dogs, and cats.…”

mentioning

confidence: 99%

Clinical utility, dose determination, and safety of ocular contrast‐enhanced ultrasonography in horses: A pilot study

Blohm

Tichy

Nell

2019

Veterinary Ophthalmology

View full text Add to dashboard Cite

Objective To determine efficacy of contrast‐enhanced ultrasonography (CEUS) using different sulfur hexafluoride (SF6) doses to assess blood flow and perfusion in equine eyes and to evaluate safety of SF6 in horses. Procedures Ocular B‐mode and contrast‐enhanced ultrasonography were performed bilaterally in nine sedated university‐owned horses. Intravenous SonoVue® bolus injections of 5, 10, 15, 20, 25, and 30 mL were administered for 2/18, 5/18, 6/18, 3/18, 1/18, and 1/18 eyes, respectively. Doses were increased based on ascending bodyweight. Each eye within one horse was examined utilizing a different dose. Qualitative blood flow and quantitative perfusion were analyzed. Heart and respiratory rates were monitored nonsedated, sedated, and during first and second minutes of CEUS. Results Qualitative contrast enhancement (CE) was visible in 7/9 animals. Quantitative CE was measurable bilaterally in four horses, unilaterally in three individuals, and not detected in two animals. In all horses with unilateral CE, the positive eye received the higher dose. Fifteen mL dose resulted in significantly shorter time to peak than 10 mL (P < .05). Peak intensity, maximum signal increase, and corresponding area under the curve were significantly higher for 15 and 20 mL doses compared with 10 mL (P < .05). Uveal and retinal tissues were enhanced frequently. Twenty‐five and 30 mL doses revealed no CE. Only sedation reduced heart rates significantly (P < .05). Clinically relevant changes in respiratory rates or adverse reactions following SF6 application were not observed. Conclusions Contrast enhancement was in most instances dose‐dependent. Fifteen mL appeared appropriate to assess equine ocular perfusion. The reliability in horses remains questionable; however, CEUS was well‐tolerated.

show abstract

Comparison of ultrasonography and histologic examination for identification of ocular diseases of animals: 113 cases (2000–2010)

Cited by 22 publications

References 23 publications

Quantitative, noninvasive assessment of intra‐ and extraocular perfusion by contrast‐enhanced ultrasonography and its clinical applicability in healthy dogs

Quantitative, noninvasive assessment of intra‐ and extraocular perfusion by contrast‐enhanced ultrasonography and its clinical applicability in healthy dogs

A survey of ocular ultrasound abnormalities in horse: 145 cases

Clinical utility, dose determination, and safety of ocular contrast‐enhanced ultrasonography in horses: A pilot study

Contact Info

Product

Resources

About