Comparison of viscoelastic coagulation analysis and standard coagulation profiles in critically ill neonatal foals to outcome

Abstract

Viscoelastic coagulation evaluation could be used in a neonatal intensive care unit setting to further characterize coagulopathy, and identify foals at higher risk for poor outcome.

Sonoclot Signature Analysis in Patients with Liver Disease and Its Correlation with Conventional Coagulation Studies

“…The correlation between conventional coagulation tests and sonoclot parameters is rather limited [17, 18]. In this study we have tried to compare the sonoclot parameters with conventional tests so as to be able to replace the need for several coagulation tests in these patients with sonoclot.…”

Characterisation of clotting factors, anticoagulant protein activities and viscoelastic analysis in healthy donkeys

“…Thromboelastography provides a global assessment of the coagulation steps in real time, from clot formation to fibrinolysis . Reference ranges for the Sonoclot, a viscoelastic coagulation and platelet function analyser, have been reported in foals and adult horses, including both healthy animals and those with different disturbances . Nonetheless, there are no published data concerning thromboelastography in donkeys, using either the Sonoclot or other analysis systems such as rotational thromboelastometry (ROTEM).…”

Coagulopathy of the critically ill equine patient

“…Healthy foals were found to have increased platelet activity compared with adult horses, and an association with positive blood culture status and hypocoagulability (decreased clot rate) was identified in a small group of foals with sepsis 79 . In a slightly larger study evaluating standard coagulation profiles, SCPFA variables, and outcome in foals with presumed sepsis, hypocoagulability (decreased CR) was associated with death, and prolonged ACT (delayed clot formation) as well as hypocoagulability was associated with development of coagulopathy 80 …”

“…These analyzers are currently being evaluated in horses and may be useful in the future for use in clinical cases. Coagulation evaluation of healthy foals, a small number of adults, and foals with suspected sepsis has been explored using the SCPFA 79,80 . Healthy foals were found to have increased platelet activity compared with adult horses, and an association with positive blood culture status and hypocoagulability (decreased clot rate) was identified in a small group of foals with sepsis 79 .…”

“…TEG has also been evaluated in horses with gastrointestinal disease b . Although there are no published reference intervals, SCPFA has been used to evaluate coagulopathies in horses with gastrointestinal disease, 54 septic foals, 13,79,80 and experimentally induced endotoxemia 95,96…”