Compartment-restricted and rate-controlled dual drug delivery system using a biosilica-enveloped ferritin cage

Ki, Mi-Ran; Kim, Jong Ki; Kim, Sung Hoon; Nguyen, Thi Khoa My; Kim, Kyung Hee; Pack, Seung Pil

doi:10.1016/j.jiec.2019.09.027

Cited by 29 publications

(17 citation statements)

References 57 publications

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“…The mRFP or PTX exhibits short-term release, while DOX shows a sustained release. The compartment-based and rate-controlled dDDS with the PTX-DOX combination attains a two-fold higher cytotoxicity than the single DOX [ 91 ].…”

Section: Cytotoxicity and Anticancer Activities Of Drug-loaded Msnsmentioning

confidence: 99%

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Novel Drug and Gene Delivery System and Imaging Agent Based on Marine Diatom Biosilica Nanoparticles

et al. 2022

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Mesoporous silica nanoparticles (MSNs) have great potential for applications as a drug delivery system (DDS) due to their unique properties such as large pore size, high surface area, biocompatibility, biodegradability, and stable aqueous dispersion. The MSN-mediated DDS can carry chemotherapeutic agents, optical sensors, photothermal agents, short interfering RNA (siRNA), and gene therapeutic agents. The MSN-assisted imaging techniques are applicable in cancer diagnosis. However, their synthesis via a chemical route requires toxic chemicals and is challenging, time-consuming, and energy-intensive, making the process expensive and non-viable. Fortunately, nature has provided a viable alternative material in the form of biosilica from marine resources. In this review, the applications of biosilica nanoparticles synthesized from marine diatoms in the field of drug delivery, biosensing, imaging agents, and regenerative medicine, are highlighted. Insights into the use of biosilica in the field of DDSs are elaborated, with a focus on different strategies to improve the physico-chemical properties with regards to drug loading and release efficiency, targeted delivery, and site-specific binding capacity by surface functionalization. The limitations, as well as the future scope to develop them as potential drug delivery vehicles and imaging agents, in the overall therapeutic management, are discussed.

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Section: Cytotoxicity and Anticancer Activities Of Drug-loaded Msnsmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Novel Drug and Gene Delivery System and Imaging Agent Based on Marine Diatom Biosilica Nanoparticles

et al. 2022

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“…Drug delivery systems (DDS) were advocated to describe new formulations by numerous researchers. 1–4 DDS provides a great channel for the combination of an effective active pharmaceutical ingredient and a tailored controlled-release rate. 5,6 It provides advantages over conventional dosage forms, such as an optimum drug concentration released at the desired site, reduced fluctuation of the drug concentration in vivo to improve the efficiency of treatment with a minimal amount of drug, and the prevention of drug exposure to other parts of the organism.…”

Section: Introductionmentioning

confidence: 99%

Electrospun collagen core/poly-l-lactic acid shell nanofibers for prolonged release of hydrophilic drug

et al. 2021

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“…The internal cavity of apoferritin can be filled with small molecular compounds such as heavy metals and organophosphorus pesticides. 9,22,23 Therefore, the incomparable structure of ferritin allows drug encapsulation and loading. A notable property of ferritin is that it can withstand temperatures above 75 • C for 10 min.…”

Section: Introductionmentioning

confidence: 99%

“…The outer surface of ferritin nanoparticles can be chemically modified. The internal cavity of apoferritin can be filled with small molecular compounds such as heavy metals and organophosphorus pesticides 9,22,23 . Therefore, the incomparable structure of ferritin allows drug encapsulation and loading.…”

Section: Introductionmentioning

confidence: 99%

Apoferritin nanocages for targeted delivery of idarubicin against breast cancer cells

Rafipour

Mousavi

Mansouri

2021

Biotech and App Biochem

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In recent years, nanotechnology has attracted attention for its capability to diagnose and remedy diverse tumors successfully. Protein nanocarriers as a platform of targeted drug delivery can be used to reduce toxicity and improve the effect of anticancer drugs. Idarubicin (IDR) is a chemotherapy drug that is classified as an anthracycline antitumor. In this study, IDR was encapsulated within horse spleen apoferritin (HsAFr) nanocarriers. Encapsulation was obtained through disassembling apoferritin into subunits at pH 2 and subsequently reassembling it at pH 7.4 in the presence of IDR. Transmission electron microscopy, UV-vis, and fluorescence spectroscopy techniques showed that drug molecules are loaded within apoferritin. Intrinsic fluorescence information exhibited that the encapsulation does not have any effects on the tertiary structure of the protein. Drug loading and entrapment efficiency were found to be 7.15% and 84.75%, respectively. Comparison of anticancer activities in HsAFr-IDR and free drug IDR was made via the MTT viability technique in a human breast cancer cell line (MCF-7).

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Compartment-restricted and rate-controlled dual drug delivery system using a biosilica-enveloped ferritin cage

Cited by 29 publications

References 57 publications

Novel Drug and Gene Delivery System and Imaging Agent Based on Marine Diatom Biosilica Nanoparticles

Novel Drug and Gene Delivery System and Imaging Agent Based on Marine Diatom Biosilica Nanoparticles

Electrospun collagen core/poly-l-lactic acid shell nanofibers for prolonged release of hydrophilic drug

Apoferritin nanocages for targeted delivery of idarubicin against breast cancer cells

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