Electrospun collagen core/poly-<scp>l</scp>-lactic acid shell nanofibers for prolonged release of hydrophilic drug

Huang, Wanying; Hibino, Toshiya; Suye, Shin‐ichiro; Fujita, Shin

doi:10.1039/d0ra08353d

Cited by 26 publications

(25 citation statements)

References 60 publications

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“… Microstructure of PLLA-based hybrid scaffold in combination with natural polymers, synthetic polymers or inorganic biomaterials. Reprinted with permission from RSC [ 135 ] and MDPI [ 136 , 137 ]. …”

Section: Figurementioning

confidence: 99%

Poly-l-Lactic Acid (PLLA)-Based Biomaterials for Regenerative Medicine: A Review on Processing and Applications

et al. 2022

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Synthetic biopolymers are effective cues to replace damaged tissue in the tissue engineering (TE) field, both for in vitro and in vivo application. Among them, poly-l-lactic acid (PLLA) has been highlighted as a biomaterial with tunable mechanical properties and biodegradability that allows for the fabrication of porous scaffolds with different micro/nanostructures via various approaches. In this review, we discuss the structure of PLLA, its main properties, and the most recent advances in overcoming its hydrophobic, synthetic nature, which limits biological signaling and protein absorption. With this aim, PLLA-based scaffolds can be exposed to surface modification or combined with other biomaterials, such as natural or synthetic polymers and bioceramics. Further, various fabrication technologies, such as phase separation, electrospinning, and 3D printing, of PLLA-based scaffolds are scrutinized along with the in vitro and in vivo applications employed in various tissue repair strategies. Overall, this review focuses on the properties and applications of PLLA in the TE field, finally affording an insight into future directions and challenges to address an effective improvement of scaffold properties.

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Section: Figurementioning

confidence: 99%

Poly-l-Lactic Acid (PLLA)-Based Biomaterials for Regenerative Medicine: A Review on Processing and Applications

et al. 2022

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“…On the other hand, core-shell nanofibers provided a controllable long-term release, which could be induced by diffusion and slow degradation of the shell, being the complete release achieved after 192 h. Figure 9 shows the proposed drug release mechanism from monolithic and core-shell nanofibers. [59] Alishahi et al showed that the core-shell structures were able to reduce the initial burst release and prolong the release for 9 h, whereas almost all the loaded drug was released after 5 h when using single blended nanofibers. [140] Another research work also demonstrated the ability of core-shell to decrease the initial burst release obtained with blended nanofibers.…”

Section: Drug Release Profiles From Electrospun Fibersmentioning

confidence: 99%

Drug Delivery Systems for Photodynamic Therapy: The Potentiality and Versatility of Electrospun Nanofibers

Costa

Fangueiro

Ferreira

2022

Macromolecular Bioscience

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Recently, photodynamic therapy (PDT) has become a promising approach for the treatment of a broad range of diseases, including oncological and infectious diseases. This minimally invasive and localized therapy is based on the production of reactive oxygen species able to destroy cancer cells and inactivate pathogens by combining the use of photosensitizers (PSs), light, and molecular oxygen. To overcome the drawbacks of drug systemic administration, drug delivery systems (DDS) can be used to carrier the PSs, allowing higher therapeutic efficacy and minimal toxicological effects. Polymeric nanofibers produced by electrospinning emerged as powerful platforms for drug delivery applications. Electrospun nanofibers exhibit outstanding characteristics, such as large surface‐area‐to‐volume ratio associated with high drug loading, high porosity, flexibility, ability to incorporate and release a wide variety of therapeutic agents, biocompatibility, and biodegradability. Due to the versatility of this technique, fibers with different morphologies and functionalities, including drug release profile can be produced. The possibility of scalability makes electrospinning even more attractive for the development of DDS. This review aims to explore and show an up to date of the huge potential of electrospun nanofibers as DDS for different PDT applications and discuss the opportunities and challenges in this field.

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“…Electrospinning is one of the feasible techniques for the fabrication of topographic patterns. The architecture of electrospun nanofibers is similar to the collagen structure in natural ECM that supports cells with mechanical properties and chemical signals. − Nanofibers with a controlled orientation are used to guide cell migration and interdict cell spreading . They can also be used to mimic the aligned topographical features of the white matter tract in vivo microenvironment, because the white matter tracts with highly oriented structures serve as migration routes for GBM cells.…”

Section: Introductionmentioning

confidence: 99%

Cell Trapping via Migratory Inhibition within Density-Tuned Electrospun Nanofibers

Huang

Suye

Fujita

2021

ACS Appl. Bio Mater.

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Cell migration is an essential bioprocess that occurs during wound healing and tissue regeneration. Abnormal cell migration is observed in various pathologies, including cancer metastasis. Glioblastoma multiforme (GBM) is an aggressive and highly infiltrative brain tumor. The white matter tracts are considered the preferred routes for GBM invasion and the subsequent spread throughout the brain tissue. In the present study, a platform based on electrospun nanofibers with a consistent alignment and controlled density was designed to inhibit cell migration. The observation of the cells cultured on the nanofibers with different fiber densities revealed an inverse correlation between the cell migration velocity and nanofiber density. This was attributed to the formation of focal adhesions (FAs). The FAs in the sparse fiber matrix were small, whereas those in the dense fiber matrix were large, aligned with the nanofibers, and distributed throughout the cells. A nanofiber-based platform with stepwise different fiber densities was designed based on the aforementioned observation. A time-lapse observation of the GBM cells cultured on the platform revealed a directional one-way migration that induced the entrapment of cells in the dense-fiber zone. The designed platform mimicked the structure of the white matter tracts and enabled the entrapment of migrating cells. The demonstrated approach is suitable for inhibiting metastasis and understanding the biology of invasion, thereby functioning as a promising therapeutic strategy for GBM.

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Electrospun collagen core/poly-l-lactic acid shell nanofibers for prolonged release of hydrophilic drug

Abstract: A hydrophilic drug was encapsulated in nanofibers with hydrophobic shell using core–shell electrospinning. Drug–polymer miscibility affected the crystallinity of drug-loaded nanofibers. Our results propose a way to prolong the release of hydrophilic drugs from nanofibers.

Cited by 26 publications

References 60 publications

Poly-l-Lactic Acid (PLLA)-Based Biomaterials for Regenerative Medicine: A Review on Processing and Applications

Poly-l-Lactic Acid (PLLA)-Based Biomaterials for Regenerative Medicine: A Review on Processing and Applications

Drug Delivery Systems for Photodynamic Therapy: The Potentiality and Versatility of Electrospun Nanofibers

Cell Trapping via Migratory Inhibition within Density-Tuned Electrospun Nanofibers

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