Compatibility and Stability of 5-HT&lt;sub&gt;3&lt;/sub&gt; Receptor Antagonists: A Pharmacology Review

Longfield, Viki

doi:10.1188/02.onf.1469-1482

Cited by 3 publications

(2 citation statements)

References 23 publications

(18 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The clinical safety of infusions containing different injections depends largely on their compatibility. Although there have been several reports on the compatibility of DSP with 5-HT3RAs in infusion solutions,8 the available evidence is not yet conclusive. Up to now, the compatibility of DSP with tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride and ramosetron hydrochloride has not been reported.…”

Section: Introductionmentioning

confidence: 99%

Compatibility of dexamethasone sodium phosphate with 5-HT₃receptor antagonists in infusion solutions: a comprehensive study

Zeng

Lou

et al. 2016

Eur J Hosp Pharm

View full text Add to dashboard Cite

ObjectivesPatients can benefit from the coadministration of several medications because of the shorter infusion time and more rapid administration. The use of extemporaneously prepared admixtures of dexamethasone sodium phosphate (DSP) and 5-HT3 receptor antagonists (5-HT3RAs) must be supported by sufficient documentation of their compatibility. The objective of this study was to comprehensively investigate the compatibility of DSP with 5-HT3RAs in infusion solutions.MethodsAdmixtures of DSP with six different 5-HT3RAs (ondansetron hydrochloride, tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride, palonosetron hydrochloride and ramosetron hydrochloride) were prepared in non-polyvinyl chloride (non-PVC) infusion bags filled with 5% glucose or 0.9% NaCl. Bags were stored at ambient temperature (25±2°C) without protection from light. Samples were taken immediately after preparation (0 hour) and at predetermined intervals (12, 24 and 48 hours after preparation). Particulate matter of admixtures was inspected visually and particles were counted with a particle counter. The pH of each sample was also determined. Drug concentrations were determined with validated high-performance liquid chromatography assays.ResultsNo visible haze or particulate formation, colour change or gas evolution and no notable changes in pH were observed, and particulate matter was acceptable up to 48 hours. All preparations maintained more than 90.0% of the initial concentration over the study period.ConclusionsAll the admixtures of DSP and the 5-HT3RAs studied were compatible and stable for at least 48 hours in a 5% glucose injection or a 0.9% NaCl injection stored in non-PVC infusion bags under ambient conditions.

show abstract

Section: Introductionmentioning

confidence: 99%

Compatibility of dexamethasone sodium phosphate with 5-HT₃receptor antagonists in infusion solutions: a comprehensive study

Zeng

Lou

et al. 2016

Eur J Hosp Pharm

View full text Add to dashboard Cite

show abstract

“…Chemical incompatibility and instability of the drugs in the mixtures will result in an inadequate therapeutic outcome, and the degradation products may cause undesirable side effects. [13] In the literature, the compatibility and stability of lornoxicam with the 4 antiemetic medications in infusion solutions for PCA has not yet been documented. Therefore, the objective of this study was to determine the compatibility and stability of lornoxicam with the 4 antiemetic medications in 0.9% sodium chloride injection when stored in polyolefin bags at room temperature for 48 hours.…”

Section: Introductionmentioning

confidence: 99%

Incompatibilities of lornoxicam with 4 antiemetic medications in polyolefin bags during simulated intravenous administration

Fang

Shi²,

Chen³

et al. 2016

Medicine

View full text Add to dashboard Cite

The administration of drugs by patient-controlled analgesia (PCA) is routinely practiced for the management of postoperative pain. It is common for 2 or more drugs to be combined in PCA solutions. The combination of analgesics and antiemetic agents is frequently required. Unfortunately, the compatibility and stability of lornoxicam and antiemetic agents, such as droperidol, ondansetrone, granisetron, and tropisetron, has not been determined. The aim of this study was to evaluate the compatibility and stability of solutions containing lornoxicam with the 4 antiemetic agents in combination for PCA administration.In our study, test samples were prepared in triplicate by adding 40 mg lornoxicam and 5 mg droperidol, 8 mg ondansetron, 6 mg granisetron, or 5 mg tropisetron to 100-mL polyolefin bags of sodium chloride 0.9% and stored at 25 °C. The analgesic mixture samples were visually inspected for precipitation, cloudiness, and discoloration at each sampling interval. Drug concentrations were determined using high-performance liquid chromatographic (HPLC) analysis.No loss of lornoxicam occurred with any of the 4 antiemetic agents tested for up to 48 hours. However, the contents of droperidol, ondansetron, granisetron, and tropisetron were significant loss >48 hours. After storage of 4.0 to 48.0 hours, the presence of a slight precipitate was observed in all the injection combinations.The results indicate that combinations of lornoxicam with droperidol, ondansetrone, granisetron, or tropisetron in infusion solution during simulated intravenous PCA administration were incompatibility when stored protected from light at 25 °C.

show abstract

Compatibility of intravenous fosaprepitant with intravenous 5-HT3 antagonists and corticosteroids

Sun

Schaller

Placek

et al. 2013

Cancer Chemother Pharmacol

View full text Add to dashboard Cite

show abstract

Compatibility and Stability of 5-HT<sub>3</sub> Receptor Antagonists: A Pharmacology Review

Abstract: To maximize patients' outcomes, oncology nurses must be knowledgeable about stability and compatibility of complex multidrug regimens that include the commonly used 5-HT3 receptor antagonist antiemetics.

Cited by 3 publications

References 23 publications

Compatibility of dexamethasone sodium phosphate with 5-HT₃receptor antagonists in infusion solutions: a comprehensive study

Compatibility of dexamethasone sodium phosphate with 5-HT₃receptor antagonists in infusion solutions: a comprehensive study

Incompatibilities of lornoxicam with 4 antiemetic medications in polyolefin bags during simulated intravenous administration

Compatibility of intravenous fosaprepitant with intravenous 5-HT3 antagonists and corticosteroids

Contact Info

Product

Resources

About

Compatibility and Stability of 5-HT<sub>3</sub> Receptor Antagonists: A Pharmacology Review

Abstract: To maximize patients' outcomes, oncology nurses must be knowledgeable about stability and compatibility of complex multidrug regimens that include the commonly used 5-HT3 receptor antagonist antiemetics.

Cited by 3 publications

References 23 publications

Compatibility of dexamethasone sodium phosphate with 5-HT3receptor antagonists in infusion solutions: a comprehensive study

Compatibility of dexamethasone sodium phosphate with 5-HT3receptor antagonists in infusion solutions: a comprehensive study

Incompatibilities of lornoxicam with 4 antiemetic medications in polyolefin bags during simulated intravenous administration

Compatibility of intravenous fosaprepitant with intravenous 5-HT3 antagonists and corticosteroids

Contact Info

Product

Resources

About

Compatibility of dexamethasone sodium phosphate with 5-HT₃receptor antagonists in infusion solutions: a comprehensive study

Compatibility of dexamethasone sodium phosphate with 5-HT₃receptor antagonists in infusion solutions: a comprehensive study