Compatibility of dexamethasone sodium phosphate with 5-HT₃receptor antagonists in infusion solutions: a comprehensive study

Abstract

ObjectivesPatients can benefit from the coadministration of several medications because of the shorter infusion time and more rapid administration. The use of extemporaneously prepared admixtures of dexamethasone sodium phosphate (DSP) and 5-HT3 receptor antagonists (5-HT3RAs) must be supported by sufficient documentation of their compatibility. The objective of this study was to comprehensively investigate the compatibility of DSP with 5-HT3RAs in infusion solutions.MethodsAdmixtures of DSP with six different 5-HT3RAs (ondansetron hydrochloride, tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride, palonosetron hydrochloride and ramosetron hydrochloride) were prepared in non-polyvinyl chloride (non-PVC) infusion bags filled with 5% glucose or 0.9% NaCl. Bags were stored at ambient temperature (25±2°C) without protection from light. Samples were taken immediately after preparation (0 hour) and at predetermined intervals (12, 24 and 48 hours after preparation). Particulate matter of admixtures was inspected visually and particles were counted with a particle counter. The pH of each sample was also determined. Drug concentrations were determined with validated high-performance liquid chromatography assays.ResultsNo visible haze or particulate formation, colour change or gas evolution and no notable changes in pH were observed, and particulate matter was acceptable up to 48 hours. All preparations maintained more than 90.0% of the initial concentration over the study period.ConclusionsAll the admixtures of DSP and the 5-HT3RAs studied were compatible and stable for at least 48 hours in a 5% glucose injection or a 0.9% NaCl injection stored in non-PVC infusion bags under ambient conditions.

Microstructure and Properties of Polytetrafluoroethylene Composites Modified by Carbon Materials and Aramid Fibers

“…PTFE has incomparable corrosion resistance, self-lubrication and high and low temperature resistance, which are unmatched by metal materials [2]. Thus, it is often used on the surface of some objects, such as textiles [3,4], valves [5], pipes [6], etc., through the fluorine lining process. Especially when PTFE is used as a sealing material, it is necessary to increase the elastic modulus of PEFT to prevent creep phenomenon [7], which will lead to leakage.…”

A Fast and Validated HPLC Method for the Simultaneous Analysis of Five 5-HT3 Receptor Antagonists via the Quantitative Analysis of Multicomponents by a Single Marker

“…According to the literature [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24], acetonitrile and acidic water media were selected to optimize the mobile phase composition. A series of concentrations, pH values, the ratio of aqueous potassium dihydrogen phosphate solution, and different chromatographic column types were studied to ensure good resolution and appropriate retention time of the five 5-HT 3 receptor antagonists.…”

“…HPLC is commonly used to verify rapid detection systems due to its attractive features, such as high peak efficiencies, great resolution, high sensitivity, good repeatability, and wide application range. HPLC analytic methods for the detection of 5-HT 3 receptor antagonists such as ODT, GNT, TPT, AZT, and RMT are already mature, and most of them use retention data in the qualitative analysis, while the external standard method (ESM) is applicable in quantitative analysis [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24]. However, some of these methods may take a long time, and the specific drugs to be tested must correspond to reference substances, which cannot meet the requirements of rapid drug detection.…”

<p>Stability and Compatibility of Ramosetron with Midazolam in 0.9% Sodium Chloride Injection for Postoperative Nausea and Vomiting Administration</p>

“…The wavelength selection and detection for midazolam and ramosetron were 220 nm and 230 nm, respectively. 15,16…”

“…In this experiment, the methods for the determination of ramosetron hydrochloride and midazolam were adapted from the published literature. 14,16 An alkaline aqueous medium and Figure 3 Chromatograms of midazolam hydrochloride (0.5 mg/100 mL) that was freshly prepared (A), exposed to 0.1 mol/L hydrochloric acid at 60°C for 5 hrs (B), exposed to 0.1 mol/L sodium hydroxide at 60°C for 5 hrs (C), and exposed to 3% hydrogen peroxide at 60°C for 5 hrs (D). Midazolam hydrochloride eluted at 9.08 min.…”