Compatibility of epirubicin-loaded DC bead™ with different non-ionic contrast media

Sarakbi, Iman; Krämer, Irene

doi:10.1177/1078155215607088

Cited by 5 publications

(1 citation statement)

References 12 publications

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“…Each sample was assayed three times by a validated stability-indicating reversed-phase HPLC assay with PDA to analyse the concentration and purity of epirubicin. The HPLC method was implemented and validated by Sarakbi et al 18 The HPLC system consisted of a Waters 717 plus Autosampler, a Waters 510 HPLC-pump, and a Waters 996 photodiode array detector. The software used was the Waters Empower Pro, Empower 2 software, version 6.10.01.00 (Waters, Eschborn, Germany).…”

Section: Hplc Assaymentioning

confidence: 99%

Loading, release and stability of epirubicin-loaded drug-eluting beads

Spindeldreier

Thiesen

Krämer

2015

J Oncol Pharm Pract

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Section: Hplc Assaymentioning

confidence: 99%

Loading, release and stability of epirubicin-loaded drug-eluting beads

Spindeldreier

Thiesen

Krämer

2015

J Oncol Pharm Pract

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Effects of HepaSphere microsphere encapsule epirubicin with a new loading method transarterial chemoembolization: in vitro and in vivo experiments

Zhang,

Du,

Wang

et al. 2023

Discov Onc

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Methods HS microspheres were loaded in a solution of hypertonic saline and contrast medium at different ratios. Morphology, size distribution, and drug loading capacity of the microsphere were evaluated. Rabbits with hepatic VX2 tumors underwent conventional TACE, drug-eluting beads TACE with HS microsphere loading epirubicin by recommended method (dTACE) or a new loading method (ndTACE). The plasma and tissue epirubicin concentration, tumor necrosis, and the microsphere distribution within the tumor were assessed. Results It was found that the mean diameter of HS microspheres was effectively reduced to 102 ± 14 μm after loading with 10.0% NaCl and Ultravist (370 mg I /mL) at a ratio of 2: 8 ml. The loading capacity reached 78.7%. It was noted that the concentration of tumor epirubicin was significantly higher (p = 0.016) in the ndTACE group (11,989.8 ± 5776.6 ng/g) than the concentration in the dTACE (6516.5 ± 3682.3 ng/g) and in cTACE groups (1564.1 ± 696.1 ng/g, p < 0.001). Further, the tumor necrosis in group with the new loading method (ndTACE) was 92.4%. Conclusions The size of HS microsphere can be effectively reduced when it is loaded with a mixture of hypertonic saline and non-ionic contrast material. HS microsphere loaded with epirubicin using the new method (ndTACE) can increase the drug concentration in tumor and hence exert better improved antitumor effect.

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A biodegradable multifunctional porous microsphere composed of carrageenan for promoting imageable trans-arterial chemoembolization

Liu

Jin

et al. 2020

International Journal of Biological Macromolecules

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Compatibility of epirubicin-loaded DC bead™ with different non-ionic contrast media

Cited by 5 publications

References 12 publications

Loading, release and stability of epirubicin-loaded drug-eluting beads

Loading, release and stability of epirubicin-loaded drug-eluting beads

Effects of HepaSphere microsphere encapsule epirubicin with a new loading method transarterial chemoembolization: in vitro and in vivo experiments

A biodegradable multifunctional porous microsphere composed of carrageenan for promoting imageable trans-arterial chemoembolization

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