In this paper, an SEIVR epidemic model with generalized incidence and preventive vaccination is considered. First, we formulate the model and obtain its basic properties. Then, we find the equilibrium points of the model, the disease-free and the endemic equilibrium. The stability of disease-free and endemic equilibrium is associated with the basic reproduction number R 0 . If the basic reproduction number R 0 < 1, the diseasefree equilibrium is locally as well as globally asymptotically stable. Moreover, if the basic reproduction number R 0 > 1, the disease is uniformly persistent and the unique endemic equilibrium of the system is locally as well as globally asymptotically stable under certain conditions. Finally, the numerical results justify the analytical results.