2008
DOI: 10.1016/j.vaccine.2007.11.041
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Complete rejection of a T-cell lymphoma due to synergism of T-cell receptor costimulatory molecules, CD80, CD40L, and CD40

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Cited by 8 publications
(7 citation statements)
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“…faecalis CECT7121 exerted enhancing effects by the establishment of an IL-12 and TNFa-rich scenario prior to the challenge with the tumour cells. Ruybal et al (2007), working with athymic mice and LBC cells transfected with co-stimulatory molecules, have suggested that the innate mechanisms are also of importance in the primary rejection of LBC tumour cells. Furthermore, our studies concerning the expression of co-stimulatory surface molecules on bone marrow-derived dendritic cells showed that wild-type Ent.…”
Section: Discussionmentioning
confidence: 99%
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“…faecalis CECT7121 exerted enhancing effects by the establishment of an IL-12 and TNFa-rich scenario prior to the challenge with the tumour cells. Ruybal et al (2007), working with athymic mice and LBC cells transfected with co-stimulatory molecules, have suggested that the innate mechanisms are also of importance in the primary rejection of LBC tumour cells. Furthermore, our studies concerning the expression of co-stimulatory surface molecules on bone marrow-derived dendritic cells showed that wild-type Ent.…”
Section: Discussionmentioning
confidence: 99%
“…with a lethal dose of LBC cells (2·0 × 10 6 cells ml −1 , 0·5 ml). Animal survival was then monitored during 26 days (Ruybal et al. 2007).…”
Section: Methodsmentioning
confidence: 99%
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“…CD40 is one of the most important TCR 6 first one involves antigen presentation to the TCR in the context of MHC and the second signal needs the engagement of each costimulatory molecule with its ligand to avoid anergy. In previous works we have demonstrated that LBC tumor cells transfected with CD40 (LBC.CD40) 7 induced a significant increase in specific cytotoxic T-cell activity, IFN- secretion, and significant tumor rejection after LBC.CD40 inoculation [12]. CD40 has also been used as a molecular adjuvant to enhance weak immunogenic vaccines, as is the case of DNA vaccines.…”
Section: Accepted Manuscriptmentioning
confidence: 99%