Complete response to paclitaxel, ifosfamide, and cisplatin therapy in a case of ovarian ependymoma

Hino, Makiko; Kobayashi, Yusuke; Wada, Mitsuru; Hattori, Yoshihisa; Kurahasi, Takashi; Nakagawa, Hiroyuki

doi:10.1111/jog.13084

Cited by 5 publications

(3 citation statements)

References 16 publications

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“…Hirahara et al reported a case of pure ovarian ependymoma which had undergone chemotherapy such as cisplatin, CAP (cisplatin/aclarubicin/cyclophosphamide), VAC (vincristine/dactinomycin/cyclophosphamide), EP (etoposide/cisplatin), and doxorubicin/mitomycin C [15]. Hino et al reported a case of ovarian ependymoma failing BEP (bleomycin/etoposide/cisplatin) with complete response after treatment with TIP (paclitaxel/ifosfamide/cisplatin) [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Metastatic Primary Peritoneal Ependymoma: A Case Report and Literature Review

Cheung

Lau

et al. 2020

Case Reports in Oncological Medicine

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Background. Primary peritoneal ependymoma is an exceedingly rare tumour with only four cases reported in the literature. It typically follows an indolent disease course. We describe a rare case of metastatic primary peritoneal ependymoma which was treated with chemotherapy and radiotherapy resulting in prolonged survival to date for 10 years. Case Presentation. The patient was a 23-year-old female on presentation. She presented with right upper quadrant pain associated with an abdominal mass. Computed tomography demonstrated a large mass displacing the liver. Debulking surgery was done revealing a tumour arising from the peritoneum as well as multiple metastatic pleural and peritoneal nodules. Pathology was consistent with primary peritoneal ependymoma. The patient was then treated with multiple lines of chemotherapy containing etoposide as the backbone. She also received palliative radiotherapy to the thoracic metastases with good and durable response. Conclusion. We reported a rare case of metastatic primary peritoneal ependymoma. Etoposide containing the chemotherapy regimen is effective in the treatment of peritoneal ependymoma. Radiotherapy is also effective for palliation of local symptoms with durable response.

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Section: Discussionmentioning

confidence: 99%

A Rare Case of Metastatic Primary Peritoneal Ependymoma: A Case Report and Literature Review

Cheung

Lau

et al. 2020

Case Reports in Oncological Medicine

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“…Hence, in the literature, the treatment of ovarian ependymoma is primarily based on the treatment of malignant germ cell tumours, including surgical debulking followed by adjuvant chemotherapy. The traditional first-line chemotherapy regimen consisting of bleomycin, etoposide and cisplatin(BEP) for germ cell tumours is effective for ovarian ependymomas [ 1 , 5 ]. Moreover, Hino et al have suggested that paciltaxel, ifosfamide, and cisplatin therapy can be used as an effective second-line therapy for ovarian ependymomas resistant to BEP therapy [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

Ovarian ependymoma presenting in pregnancy: a case report and literature review

Jin

Jiang

Peng

2020

BMC Pregnancy Childbirth

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Background Ovarian ependymoma is a rare malignancy. Because of the extreme rarity, certain features of the neoplasm, including its clinical behaviour and optimal therapy, are incompletely characterized. Case presentation A 32-year-old pregnant woman at term presented with a left ovarian neoplasm that occurred in the early stage of pregnancy. She underwent left adnexectomy during the caesarean section, and the neoplasm was histologically and immunohistochemically identified to be ovarian ependymoma. Immunohistochemical staining with oestrogen receptors and progesterone receptors showed strong positive staining. According to reports in the literature, the pathological type of ovarian ependymoma in our patient was the extra-axial type. Interestingly, the foetus was also found to have bilateral ependymal cysts during pregnancy. The patient received no further surgical treatment or adjuvant therapy. She and her 14-month-old baby both have no evidence of disease at present. The follow-up of both mother and child is still continuing. Conclusions The case presented here illustrates high levels of oestrogen during pregnancy may stimulate viable malignant ependymal cells to proliferate. Hence, young women with extra-axial-type ependymomas may not be suitable for fertility preservation. Moreover, hormone-based therapies can be a potentially effective treatment for women with extra-axial ependymomas.

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“…The combination of paclitaxel, ifosfamide, and cisplatin (TIP) has also been identified as another chemotherapeutic option in the setting of BEP resistant disease as described in a recent case report (Hino et al, 2016). This modality has achieved success in salvage treatment of testicular malignant germ cell tumors and its use has recently been extrapolated to ovarian ependymoma.…”

Section: Discussionmentioning

confidence: 99%

Hormonal based treatment of ovarian anaplastic ependymoma with anastrozole

Górski

Taylor

Zhang

et al. 2017

Gynecologic Oncology Reports

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ObjectiveOvarian anaplastic ependymoma is a rare gynecologic malignancy that poses diagnostic and treatment challenges. Treatment of sub-optimally debulked disease usually portends poor prognosis. Molecular testing of tumor specimen can identify more specific targets for additional therapy such as estrogen and progesterone receptors (ER/PR).CaseA 29-year-old woman presented with incidental finding of large bilateral adnexal masses and elevated CA 125. Biopsy proved anaplastic ovarian ependymoma with high ER/PR expression. She underwent sub-optimal surgical debulking followed by adjuvant chemotherapy with bleomycin, etoposide and cisplatin (BEP) which resulted in a partial response. Due to extensive residual disease she has been maintained on anastrozole for over fifteen months without increased tumor burden. Targeted somatic mutation testing was negative for all high risk clinically useful variants.ConclusionAromatase inhibitors may be considered in patients with extra-axial anaplastic ependymoma and can produce prolonged stable disease.

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Complete response to paclitaxel, ifosfamide, and cisplatin therapy in a case of ovarian ependymoma

Cited by 5 publications

References 16 publications

A Rare Case of Metastatic Primary Peritoneal Ependymoma: A Case Report and Literature Review

A Rare Case of Metastatic Primary Peritoneal Ependymoma: A Case Report and Literature Review

Ovarian ependymoma presenting in pregnancy: a case report and literature review

Hormonal based treatment of ovarian anaplastic ependymoma with anastrozole

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