Complex formation of quercetin with lanthanum enhances binding to plant viral satellite double stranded RNA

To date more than 4000 compounds are recognized to belong to the class of flavonoids. These natural phenolic drugs are poorly soluble in water and are rapidly degraded and metabolized in the human body, but nevertheless are very promising for their potential contribution to the prevention and therapy of major chronic diseases, including cardiovascular and neurodegenerative diseases and cancer. In recent years a number of flavanols (e.g. catechins), flavonols (e.g. quercetin, myricetin) and isoflavones (e.g. genistein, daidzein) have been confirmed to possess strong antioxidant, anti-inflammatory, anti-proliferative and anti-aging activities. Incorporation into lipidic or polymer-based nanoparticles appears to markedly help the oral delivery of flavonoids, as these particles can protect the drug from degradation in the gastrointestinal tract and, by virtue of their unique absorption mechanism through the lymphatic system, also from first-pass metabolism in the liver. In addition, both oral and parenteral administration of flavonoids exploits a pharmacologic delivery route that guarantees sustained release of the active principle at the desired site of action. A comprehensive review of studies currently available on the in vitro and in vivo experimental administration of flavonoids by means of nanovectors may be of use as a foundation for the development of advanced delivery systems for these powerful compounds, in view of their adoption in primary and secondary disease prevention.

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“…Recent studies suggest that these effects of flavonoids could be related to their ability to bind to DNA and RNA [19,20].…”

Section: Biochemical and Biological Propertiesmentioning

confidence: 99%

Design and Development of Nanovehicle-Based Delivery Systems for Preventive or Therapeutic Supplementation with Flavonoids

Leonarduzzi

Testa

Sottero³

et al. 2010

CMC

128

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“…Moreover, the combination of platinum or other metal complexes to small RNA binders may provide a potential strategy for the development of new metallodrugs [113][114][115][116][117]. Besides covalent interaction, metal complexes can bind non-covalently to numerous non-canonical RNA structural elements [3].…”

Section: Discussionmentioning

confidence: 99%

“…In the sections below some recent advances in non-covalent binding of metal complexes to RNA are described and discussed. In particular, the following aspects are covered: (i) the use of metal complexes as RNA structural probes [40,107,108] (Section 4.1); (ii) the structure of a metal complex interacting with an RNA three-way junction [41] (Section 4.2); (iii) the development of metal complexes targeting viral RNA [109][110][111][112] (Section 4.3); (iv) the combination of metal complexes with small RNA-binding organic molecules (Section 4.4) [113][114][115][116][117]; (v) the use of RNA-targeting metal complexes in cell imaging [42,43,[118][119][120][121] (Section 4.5); (vi) comparison between DNA and RNA binding properties of some metal complexes [122][123][124][125] (Section 4.6); (vii) the RNA binding ability of some metal surfactants and metal polymers [126][127][128][129] (Section 4.7) and (viii) the binding of metal complexes to RNA triplexes [46,[130][131][132][133] (Section 4.8).…”

Section: Non-covalent Binding Of Metal Complexes To Rnamentioning

confidence: 99%

“…Also, Rusak and co-workers showed that a complex between a flavonoid quercetin and lanthanum(III) is able to bind a plant viral satellite dsRNA with higher affinity than the ligand and the metal ion alone. They suggest that such increased binding is due to a combination of ligand driven intercalation and electrostatic attraction of the positively charged lanthanum(III) centre with the negatively charged RNA backbone [117].…”

Section: Combining Metal Centre and Small Organic Rna Binders For Selmentioning

confidence: 99%

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Covalent and non-covalent binding of metal complexes to RNA

Alberti

Zampakou

Donghi

2016

Journal of Inorganic Biochemistry

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Targeting nucleic acids with metal complexes is an exciting and widely explored field of research. Following the discovery of the anticancer drug cisplatin, a number of metal complexes have been designed, synthesised, and tested for their DNA binding properties. On the contrary, the interaction of metal complexes with RNA has been much less investigated. RNA is an essential biomolecule, involved in a variety of crucial cellular functions, which offers a much wider structural diversity than DNA. As such, RNA represents an attractive target for the design and the development of structure-selective therapeutic and diagnostic agents. A few recent publications describe the ability of various metal complexes to interact with RNA, and the binding of cisplatin and derivatives to RNA is being currently investigated. This short review offers an overview of some recent advances on both covalent and non-covalent interactions of metal complexes with RNA and addresses the potential of targeting RNA non-duplex structures.

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“…La(III)-quercetin complex enhances binding to plant viral satellite dsRNA [109]. Both quercetin and the complex interact with dsDNA, dsRNA, and ssRNA.…”

Section: Flavonoids -From Biosynthesis To Human Healthmentioning

confidence: 99%

Flavonoid Complexes as Promising Anticancer Metallodrugs

Uivaroşi¹,

Arbănași²

2017

Flavonoids - From Biosynthesis to Human Health

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Flavonoid metal complexes commonly exhibit an improvement of biological activity compared to the parent ligands. This chapter is focused on the antioxidant and anticanccer properties of flavonoid metal complexes, in correlation with their binding ability to vital macromolecules such as nucleic acids and serum proteins. Perspectives for an adequate formulation of these complexes were also discussed.

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Complex formation of quercetin with lanthanum enhances binding to plant viral satellite double stranded RNA

Cited by 12 publications

References 16 publications

Design and Development of Nanovehicle-Based Delivery Systems for Preventive or Therapeutic Supplementation with Flavonoids

Design and Development of Nanovehicle-Based Delivery Systems for Preventive or Therapeutic Supplementation with Flavonoids

Covalent and non-covalent binding of metal complexes to RNA

Flavonoid Complexes as Promising Anticancer Metallodrugs

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