Complex Therapy of Atopic Cheilitis

Abstract

The aim: Was to evaluate clinical data after the use of pimecrolimus (1% cream “Elidel”) in patients with mild and moderate severity of atopic cheilitis, according to modern therapeutic requirements. There was an algorithm of treatment the patients with cheilitis proposed it based on the data from literary sources and personal clinical experience. Materials and methods: 22 patients with atopic cheilitis aged from 19 to 40 agreed on a clinical examination in accordance with the protocol of the study. Patients were prescribed “Elidel” in the form of 1% cream for lubrication of the affected areas of the skin and lips, and antihistamine “Erius”, for the normalization of the general condition used sedatives and vitamins after consultation of specialists in the general profile. Results: Patients of both groups during the re-examination after 3, 7, 10 days recorded a positive dynamics of the red border of the lips and skin: a significant reduction in the inflammatory process, normalization of indicators of general blood analysis, improvement in the overall quality of life of patients. Conclusions: The results of treatment allow to consider 1% cream “Elidel” (pimecrolimus) as a preparation of choice in the complex treatment of patients with atopic cheilitis of mild and moderate severity.

Dupilumab in the Treatment of Cheilitis in Atopic Dermatitis Patients

“…Cheilitis is a symptom of AD that significantly affects patients’ quality of life and family members. 11 However, the pathogenesis of this disease has not been thoroughly studied. However, it has been suggested that cheilitis in AD patients is characterized by IgE, hypersecretion, violation of cytokine regulation of the Th1/Th2 lymphocyte ratio, deficiency of defined T-lymphocyte suppressors, and disruption of the apoptotic process.…”

“…However, it has been suggested that cheilitis in AD patients is characterized by IgE, hypersecretion, violation of cytokine regulation of the Th1/Th2 lymphocyte ratio, deficiency of defined T-lymphocyte suppressors, and disruption of the apoptotic process. 11 …”

“…The task is to reduce symptoms, restore broken epithelial barriers, and improve quality of life. 11 The management of cheilitis is challenging due to its effects on the lips, such as topical irritation and lip-licking habits. However, limited data on the efficacy of biological agents in this specific AD localization have been reported, and consistent and high-quality evidence is lacking for guidelines on the treatment of AD with lip involvement.…”

“…However, it has been suggested that cheilitis in AD patients is characterized by IgE, hypersecretion, violation of cytokine regulation of the Th1/Th2 lymphocyte ratio, deficiency of defined T-lymphocyte suppressors, and disruption of the apoptotic process. 11 Furthermore, in a series of 202 patients with eczematous cheilitis from Singapore, endogenous etiology was the most common cause of cheilitis. 12 Since cheilitis is a chronic relapsing disease, its clinical management requires comprehensive long-term therapy.…”