Compliant electrospun silk fibroin tubes for small vessel bypass grafting

Marelli, Benedetto; Alessandrino, Antonio; Farè, Silvia; Freddi, Giuliano; Mantovani, Diego; Tanzi, Maria Cristina

doi:10.1016/j.actbio.2010.05.008

Cited by 144 publications

(135 citation statements)

References 35 publications

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“…The metabolites of PLLA and PGA are acidic, which is harmful to organism, but SF has no such a drawback. Electrospun SF scaffolds have been studied extensively in the regeneration of numerous tissues, such as skin, vessel and peripheral nerve, showing encouraging prospects (Marelli et al 2010;Jeong et al 2014;Dinis et al 2015;Sheikh et al 2015), but their effects on tendon-bone healing have not been investigated.…”

Section: Introductionmentioning

confidence: 99%

Electrospun silk fibroin mat enhances tendon-bone healing in a rabbit extra-articular model

Zhi

Zhang

et al. 2016

Biotechnol Lett

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Section: Introductionmentioning

confidence: 99%

Electrospun silk fibroin mat enhances tendon-bone healing in a rabbit extra-articular model

Zhi

Zhang

et al. 2016

Biotechnol Lett

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“…For example, Min et al (2004) found that SF nanofiber nonwovens produced by the electrospinning process promoted normal human keratinocytes and fibroblast cell adhesion and spreading. Furthermore, in vitro cytocompatibility tests have indicated that electrospun SF fibrous scaffolds support cell viability, maintain the cell phenotype, and promote cell reorganization, and composite electrospun polymeric nanofibers could be promising as tissue engineering scaffolds by blending proteins and polysaccharides in the spinning solution Marelli et al, 2010). Basal et al (2016) produced olive leaf extract-loaded coaxial nanofibers made from a blend of SF and hyaluronic acid and evaluated the potential use of these nanofibers in wound dressing applications using the HS2 cell culture test.…”

Section: Introductionmentioning

confidence: 99%

Cell-compatible PHB/silk fibroin composite nanofibermat for tissue engineering applications

Karahaliloğlu¹

2017

Turk J Biol

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Cell compatibility is one of the prominent requirements for the fabrication of tissue engineering materials. Silk fibroin (SF) is an excellent material for biomedical applications and shows desirable properties such as good compatibility, minimal tissue reaction, and tailorable degradability. Poly[(R)-3-hydroxybutyrate] (PHB) has a high percentage of crystallinity and a high melting temperature. In this study, PHB and SF were blended together to improve the mechanical properties of the SF fibrous structure and the crystallinity of PHB. Furthermore, the cell-biomaterial interaction on the PHB/SF composite scaffold was expected to be enhanced via the SF. For this purpose, PHB/SF composite scaffolds were prepared through the use of the electrospinning technique, which is a unique method for the production of biomaterials on the nanoscale intended for tissue engineering. PHB/SF scaffolds were prepared with different SF contents and a suitable electrospinning condition was chosen in terms of structure and fiber diameter. The average fiber diameter was 92 ± 2.6 nm at a flow rate of 0.4 mL/h, distance of 20 cm, polymer concentration of PHB/SF-0 of 7%:18% (w/w) or 1:1 (v/v), and voltage of 20 kV. Mechanical and crystalline properties of the PHB/SF scaffold were investigated. Adhesion and proliferation of L929 and HaCaT (mouse fibroblast and immortalized human keratinocyte cell lines) on PHB/SF-0 were examined.

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“…SF produces tubular grafts that are porous and exhibit a high tensile strength which would be suitable for vascular applications [134]. Furthermore, tubular silk scaffolds electrospun out of formic acid can resist up to 575 mmHg in burst strength tests, which is more than four times the upper physiological pressure of 120 mmHg and twice that of pathological upper pressures of 180-220 mmHg [135]. Studies have shown that electrospun aqueous SF scaffolds promote aortic EC and arterial SMC growth and proliferation while withstanding vascular pulsating pressures [136,137].…”

Section: Electrospinning Silk Fibroinmentioning

confidence: 99%

The Use of Natural Polymers in Tissue Engineering: A Focus on Electrospun Extracellular Matrix Analogues

et al. 2010

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Natural polymers such as collagens, elastin, and fibrinogen make up much of the body's native extracellular matrix (ECM). This ECM provides structure and mechanical integrity to tissues, as well as communicating with the cellular components it supports to help facilitate and regulate daily cellular processes and wound healing. An ideal tissue engineering scaffold would not only replicate the structure of this ECM, but would also replicate the many functions that the ECM performs. In the past decade, the process of electrospinning has proven effective in creating non-woven ECM analogue scaffolds of micro to nanoscale diameter fibers from an array of synthetic and natural polymers. The ability of this fabrication technique to utilize the aforementioned natural polymers to create tissue engineering scaffolds has yielded promising results, both in vitro and in vivo, due in part to the enhanced bioactivity afforded by materials normally found within the human body. This review will present the process of electrospinning and describe the use of natural polymers in the creation of bioactive ECM analogues in tissue engineering.

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Compliant electrospun silk fibroin tubes for small vessel bypass grafting

Cited by 144 publications

References 35 publications

Electrospun silk fibroin mat enhances tendon-bone healing in a rabbit extra-articular model

Electrospun silk fibroin mat enhances tendon-bone healing in a rabbit extra-articular model

Cell-compatible PHB/silk fibroin composite nanofibermat for tissue engineering applications

The Use of Natural Polymers in Tissue Engineering: A Focus on Electrospun Extracellular Matrix Analogues

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