Complications in hepatic arterial infusion chemotherapy: retrospective comparison of catheter tip placement in the right/left hepatic artery vs. the gastroduodenal artery

Abstract

The complication rates in groups 1 and 2 did not differ to a statistically significant extent.

Clinical Importance of Regimens in Hepatic Arterial Infusion Chemotherapy for Advanced Hepatocellular Carcinoma with Macrovascular Invasion

“…Regarding AEs, there were no significant differences in the incidence rate and profiles between the LFP and New FP groups. The incidence rate of severe AEs and discontinuation rate in the LFP and New FP groups in this study are in agreement with those in other studies [36,37]. Moreover, the incidence rate of severe AEs and discontinuation rate in patients treated with MTAs were higher than those treated with HAIC.…”

<p>Hepatic Arterial Infusion Oxaliplatin Plus Oral S-1 Chemotherapy in Gastric Cancer with Unresectable Liver Metastases: A Case Series and Literature Review</p>

“…[26][27][28] In terms of the technical aspects of arterial infusion we introduced here, HAI chemotherapy is often administered by surgically placing port-catheter system via the left subclavian or femoral access, while the former is preferred in our institution, above all because the leftsubclavian artery way is cleaner and more easily for catheter care, which is also a minimally invasive safe access to intervene. 29,30 In contrast to other types of local therapies for unresectable liver metastases, such as transcatheter arterial chemoembolization (TACE) and radiofrequency ablative therapy (RFA), HAI provides the following benefits: (1) There are no significant differences between TACE and HAI in the overall response and recurrence rates, but TACE leads to more serious liver dysfunction compared to HAI, which will affect treatment compliance and the quality of life; 31 (2) HAI is effective in both detectable liver lesions and intrahepatic micrometastases, whereas the therapeutic efficacy of RFA was reduced for large tumours, and the presence of as many as four or five lesions was considered suitable. 18,[32][33][34] Based on previous clinical trials, combination chemotherapy with fluorouracil and platinum agents was recognized as a standard regimen for advanced metastatic gastric cancer.…”

Hepatic Arterial Infusion of Chemotherapy for Advanced Hepatobiliary Cancers: State of the Art

“…Initially, percutaneously port-a-cath implantation consisted of placing the distal tip of the catheter into the common or proper hepatic artery. However, this approach was associated with a high rate of complications, such as catheter dislocation and hepatic artery thrombosis, potentially responsible for a temporary or permanent interruption of HAI chemotherapy [ 49 , 50 , 51 ]. Hepatic arterial thrombosis was generally due to the mechanical stimulation of the vascular endothelium by the catheter tip.…”

“…Bruising and formation of a small hematoma at the puncture and port pocket site is a frequent but minor problem [ 49 ]. Table 1 summarizes the different procedure-related complications and the range of frequency rates according to literature papers.…”