Comportamento de componentes bioquímicos do sangue em equinos submetidos à ozonioterapia

Haddad, Marcil; Souza, Maria Verônica de; Hincapié, John Jairo; Ribeiro, José Ivo; Filho, José Dantas Ribeiro; Benjamin, Laércio dos Anjos

doi:10.1590/s0102-09352009000300003

Cited by 18 publications

(20 citation statements)

References 12 publications

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“…The only prominent observation was increased defecation, probably caused by the mild rectal ampoule gas distension that facilitated a motility stimulus. The physiological parameters were within normal ranges during the treatment, similar to what was observed by Haddad (2009) in a study that used 500 and 1000ml of physiological saline with O3 for an intravenous application on healthy horses.…”

Section: Discussionsupporting

confidence: 85%

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Effects of transrectal medicinal ozone in horses - clinical and laboratory aspects

Jaramillo

Vendruscolo

Fülber

et al. 2020

Arq. Bras. Med. Vet. Zootec.

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Ozone (O3) therapy has been used for medical procedures for centuries; however, there are no extensive studies on its utilization in horses. This study aimed to evaluate the application of transrectal O3 on horses by physical and laboratorial evaluation, and production of reactive oxygen species (ROS). Sixteen healthy horses were separated in two groups: a control group (CG) and a group treated with O3 (TG). The TG animals received 1L of an oxygen and O3 mixture transrectally. The initial dose was 10µg/ml for the first two applications, 15μg/ml for the following two applications, and 20μg/ml for the next six applications. The CG animals received 1L of oxygen transrectally. In TG animals no variations in the physical examination were detected; furthermore, TG animals did not exhibit changes in biochemical evaluation results, fibrinogen concentrations, or ROS production. TG animals had increased red blood cell counts, hemoglobin concentrations, and packet cell volume values in comparison to the baseline and CG values. We could infer that O3 affected the red blood cell counts and improved rhetological properties of the blood. The transrectal application of O3 in horses is safe and can indirectly improve the oxygenation and metabolism of tissues.

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Section: Discussionsupporting

confidence: 85%

“…AST remained stable in a study by Ajamieh et al (2002) who used rectal O3 insufflation to treat ischemia/reperfusion and in a study by Haddad et al (2009) who used O3 autohemotherapy. These results corroborate with the results of the present study.…”

Section: Effects Of Transrectalmentioning

confidence: 97%

Effects of transrectal medicinal ozone in horses - clinical and laboratory aspects

Jaramillo

Vendruscolo

Fülber

et al. 2020

Arq. Bras. Med. Vet. Zootec.

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“…Ozone therapy has been used in the adjunctive treatment of wounds, assisting tissue repair in an economically viable, non-invasive way without side effects (Haddad et al 2009). Ozone is an unstable molecule with a strong oxidizing effect that eliminates microorganisms without causing resistance (Yucesoy et al 2017) and improves local inflammatory response by stimulating the synthesis and release of cytokine and growth factors, such as epidermal growth factor (EGF), platelet-derived growth factor (PDGF), transforming growth factor (TGF), and vascular endothelial growth factor (VEGF) (Araneda et al 2008, Valacchi et al 2011.…”

Section: Introductionmentioning

confidence: 99%

Ozonized solutions favor the repair of experimentally induced skin wounds in rats

et al. 2020

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This study aimed to evaluate and compare the effects of ozonized solutions on tissue wound repair in rats. Treatments consisted of ozonized water (GA), 0.9% sodium chloride (GCL), ozonized oil (GO), and 0.2% allantoin cream (GAL). The morphometric evaluation showed that wounds of the GA group presented a higher degree of retraction (p<0.05) at three and eight days of treatment (37.96 and 84.81%, respectively). Picrosirius red staining showed that groups GA and GO presented higher deposition (p<0.05) of type I collagen at 15 and 22 days of treatment, respectively. The neovascularization was higher in wounds of group GO on days 3, 8, and 15 (p<0.05), with higher VEGF immunostaining. (p<0.05). Thus, ozonized water enhances wound retraction and assists in the maturation and remodeling phase, while ozonized oil promotes higher neovascularization during tissue repair and higher deposition of type I collagen from the third week of treatment.

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“…Diante disso, para que se promova o bem-estar desses animais, inúmeras terapias têm sido desenvolvidas, dentre elas a ozonioterapia (Haddad et al, 2009;Moreira, 2015). O emprego do ozônio (O3) no tratamento de doenças agudas e crônicas tem sido eficaz, pois o mesmo ao entrar em contato com fluidos orgânicos provoca o surgimento de moléculas reativas de oxigênio, que iniciam eventos celulares bioquímicos e antimicrobianos, proporcionando a reconstituição do tecido lesionado (Bocci et al, 2011).…”

Section: Introductionunclassified

Leishmaniose visceral em canino: abordagem diagnóstica e terapêutica convencional associada com a ozonioterapia – Relato de caso

Borges

Lima²

2020

Pubvet

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A Leishmaniose Visceral Canina (LVC) é uma doença infecciosa de caráter crônico e zoonótico, causada por um protozoário pleomórfico da ordem Kinetoplastida, sendo o cão o principal reservatório doméstico de L. chagasi, tanto em ambiente urbano quanto rural, desse modo, o controle adequado e o tratamento eficaz para a manutenção do paciente com leishmaniose visceral canina faz-se importante. Assim, o objetivoneste estudo foi relatar a abordagem diagnóstica e terapêutica em canino com LVC, utilizando a ozonioterapia como suporte ao tratamento convencional. Foi atendido em uma clínica veterinária, na cidade de Santarém, Pará, um canino, macho, da raça dachshund, com quatro anos de idade, pesando 7 kg. O animal apresentava no dia da avaliação diminuição do apetite, apatia, êmese, emagrecimento, onicogrifose, alopecia, dermatite esfoliativa não pruriginosa e pelos quebradiços. O animal foi positivo no teste rápido (DPP®) para leishmaniose com resultado reagente. Como tratamento terapêutico de forma assíncrona, institui-se inicialmente a aplicação de miltefosina, alopurinol e domperidona, posteriormente administrou-se cinco sessões de ozonioterapia com intervalo de 7 dias para cada sessão. Como resultados observou-se que o paciente apresentou melhora clínica e sintomatológica, principalmente no tecido cutâneo após a administração do ozônio, sendo evidenciados resultados satisfatórios durante o tratamento, tornando-se uma opção viável para reestabilização e/ou fortalecimento do sistema leucocitário. Ademais, neste estudo, a ozonioterapia melhorou os achados clínicos e laboratoriais do paciente, porém, não reduziu a carga parasitária tal como demonstrado pela Reação em cadeia da polimerase(PCR) quantitativo.

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Comportamento de componentes bioquímicos do sangue em equinos submetidos à ozonioterapia

Cited by 18 publications

References 12 publications

Effects of transrectal medicinal ozone in horses - clinical and laboratory aspects

Effects of transrectal medicinal ozone in horses - clinical and laboratory aspects

Ozonized solutions favor the repair of experimentally induced skin wounds in rats

Leishmaniose visceral em canino: abordagem diagnóstica e terapêutica convencional associada com a ozonioterapia – Relato de caso

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