Composition design and medical application of liposomes

Li, Mingyuan; Du, Chunyang; Guo, Na; Teng, Yuou; Meng, Xin; Sun, Hua; Li, Shuangshuang; Yu, Peng; Galons, Hervé

doi:10.1016/j.ejmech.2019.01.007

Cited by 435 publications

(263 citation statements)

References 110 publications

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“…These rare liposomal characteristics enable their use in the pharmaceutical, cosmetic, and diet supplement industry [19]. Additionally, liposomes are a versatile system used in biophysical and molecular biology studies [20].…”

Section: Introductionmentioning

confidence: 99%

Identification of Abies sibirica L. Polyprenols and Characterisation of Polyprenol-Containing Liposomes

et al. 2020

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The needles of conifer trees are one of the richest sources of natural polyprenols. Polyprenol homologs from Abies sibirica L. lipophilic 80% purified extract were analyzed and quantified. In total, 10 peaks (Prenol-11 to Prenol-20) were observed in the ultra-high-performance liquid chromatography–diode array detector (UHPLC-DAD) chromatogram of Siberian fir with the most abundant compound being Prenol-15 (relative amount 37.23 + 0.56% of the total polyprenol yield). Abies sibirica L. polyprenol solubility and incorporation efficiency into liposomes were studied in various commercially available lecithin mixtures (Phosal IP40, Phosal 75SA, and Lipoid P45). The resulting multilamellar polyprenol liposomes were morphologically characterized by Light and Transmission Electron Microscopy, and the liposome size was discovered to be polymodal with the main peak at 1360 nm (90% of the volume). As polyprenols are fully soluble only in lipids, a liposomal formulation based upon co-solubilization and a modified ethanol injection method of polyprenols into the ethanol-phospholipid system was developed for the entrapment and delivery of polyprenols for potential commercial applications in food supplement and cosmetic industries.

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Section: Introductionmentioning

confidence: 99%

Identification of Abies sibirica L. Polyprenols and Characterisation of Polyprenol-Containing Liposomes

et al. 2020

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“…It is therefore very important to target the treatment directly to the infected site. Highly biocompatible and low immunogenic liposomes can serve as carriers for targeted delivery of PSs encapsulated into liposomes to the infected site [61][62][63].…”

Section: Encapsulation Of Photosensitizers In Liposomesmentioning

confidence: 99%

“…Advanced strategies for liposome preparation include charging the liposomes, attaching the ligands such as antibodies or lectins to their surface, or altering the physiological conditions such as increasing the temperature or changing the pH in the target tissues to produce heat-sensitive or pH-sensitive liposomes [65]. The works of Ghosh, Li, Bulbake, Abu Lila, and Alavi summarize the latest developments in the field of liposome design and optimization, including passive and active targeting, extended circulation, building multifunctional liposomes, and so on [62][63][64][65][66].…”

Section: Encapsulation Of Photosensitizers In Liposomesmentioning

confidence: 99%

Aspects of Photodynamic Inactivation of Bacteria

Nakonechny¹,

Nisnevitch²

2020

Microorganisms

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Increasing resistance of bacteria to antibiotics is a serious worldwide problem, and to combat resistant bacteria, new antibacterial approaches are to be developed. One alternative to traditional antibiotic therapy is photodynamic antimicrobial chemotherapy (PACT). PACT is based on excitation of photosensitizers (PS) capable of transferring the absorbed light energy to dissolved molecular oxygen causing generation of reactive oxygen species, which irreversibly damage bacterial cell components. The overall efficiency of PACT has been proven for Grampositive and Gram-negative bacteria. The effectiveness of PACT can be increased by encapsulation of PS in liposomes providing more concentrated delivery of PS, enhanced cytotoxicity, improved pharmacokinetic properties, sustained release, and prolonged action of the PS. For continuous and reusable application, PS can be immobilized in polymers. Chemiluminescence, sonodynamic treatment, and radiofrequency irradiation allow to perform excitation of PS in the dark without external illumination, opening prospects for combating internal infections. Combination of PS with antibiotics can gain a synergistic effect, allowing in some cases to overcome the resistance of bacteria to antibiotics.

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“…Liposomes are spherical vesicles containing an internal aqueous cavity enclosed by a bilayer usually made of phospholipids, often with the addition of sterols. At low temperatures, the lipid bilayer exists in an ordered state and is non-permeable for hydrophilic payloads; the content of the internal cavity is trapped inside and protected from the outside environment [1]. Therefore, liposomes can be used as carriers for the encapsulation and controlled release of active substances including small-molecule drugs [2], biomolecules [3] and genes [4,5], or as building blocks for more complex drug delivery systems [6].…”

Section: Introductionmentioning

confidence: 99%

“…The properties of liposomes can be tailored to specific delivery and release mechanisms [8,[10][11][12]. Among the most critical parameters affecting the storage stability and the final application properties of liposomes are the bilayer composition, lamellarity and size [1,[13][14][15]. These parameters can be influenced by the liposome preparation method, which typically involves the dissolution of lipids in an organic solvent and subsequent dispersion into aqueous media [16,17] with or without relying on membrane permeation of the encapsulated solute [18][19][20].…”

Section: Introductionmentioning

confidence: 99%

In-silico screening of drug candidates for thermoresponsive liposome formulations

Balouch

Šrejber

Šoltys

et al. 2020

Preprint

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Highlights-New in silico methodology for predicting drug loading and thermal release from liposomes was developed and compared with experiments -Virtual lipid bilayers were constructed using molecular dynamics models and their interaction with penetrating solutes was studied by atomistic simulations -Rules for permeability (logPerm) and partition (logKlip/wat) coefficients were established to characterise drug compatibility with liposomes -Permeability and partition coefficients of 57 toxic compounds from DrugBank database were calculated, 5 suitable candidates identified and 1 demonstrated experimentally AbstractLiposomal formulations can be advantageous in a number of scenarios such as targeted delivery to reduce the systemic toxicity of highly potent Active Pharmaceutical Ingredients (APIs), to increase drug bioavailability by prolonging systemic circulation, to protect labile APIs from degradation in the gastrointestinal tract, or to improve skin permeation in dermal delivery. However, not all APIs are suitable for encapsulation in liposomes. Some of the issues are too high permeability of the API across the lipid bilayer, which may lead to premature leakage, too low permeability, which may hinder the drug release process, or too strong membrane affinity, which may reduce the overall efficacy of drug release from liposomes. Since the most reliable way to test API encapsulation and release from liposomes so far has been experimental, an in silico model capable of predicting API transport across the lipid bilayer might accelerate formulation development. In this work, we demonstrate a new in silico approach to compute the temperature dependent permeability of a set of compounds across the bilayer of virtual liposomes constructed by molecular dynamics simulation. To validate this approach, we have conducted a series of experiments confirming the model predictions using a homologous series of fluorescent dyes. Based on the performance of individual molecules, we have defined a set of selection criteria for identifying compatible APIs for stable encapsulation and thermally controlled release from liposomes. To further demonstrate the methodology, we have screened the DrugBank database, identified potent drugs suitable for liposome encapsulation and successfully carried out the loading and thermal release of one of them -an antimicrobial compound cycloserine.

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Composition design and medical application of liposomes

Cited by 435 publications

References 110 publications

Identification of Abies sibirica L. Polyprenols and Characterisation of Polyprenol-Containing Liposomes

Identification of Abies sibirica L. Polyprenols and Characterisation of Polyprenol-Containing Liposomes

Aspects of Photodynamic Inactivation of Bacteria

In-silico screening of drug candidates for thermoresponsive liposome formulations

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