Comprehensive investigation of a wide range of pharmaceuticals and personal care products in urban and hospital wastewaters in Greece

Papageorgiou, Myrsini; Zioris, Ioannis V.; Danis, Theocharis G.; Bikiaris, Dimitrios N.; Lambropoulou, Dimitra A.

doi:10.1016/j.scitotenv.2019.07.371

Cited by 97 publications

(22 citation statements)

References 53 publications

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“…VNX presented only negative removal efficiencies (between −132.6% and −5.2%) while CBZ, BUP, MTZ and STR, in most of the cases presented also negative eliminations. Similar results have been reported elsewhere where negative removal of a wide range of PhACs in conventional WWTPs has been described ( Couto et al, 2019 ; Evgenidou et al, 2015 ; Kosma et al, 2014 ; Papageorgiou et al, 2019 ; Pereira et al, 2015 ; Yuan et al, 2013 ). FLX, FVX and RIS presented generally medium to high removal efficiencies, >70% in most of the cases.…”

Section: Resultssupporting

confidence: 91%

“…Negative, low, medium and high removals were found depending on the pharmaceutical compound. Alike removals for the studied PhACs were reported in previous works ( Evgenidou et al, 2015 ; Kosma et al, 2014 ; Paíga et al, 2019 ; Papageorgiou et al, 2019 ; Stamatis and Konstantinou, 2013 ). Variation in the removals of PhACs was frequently observed since there are diverse factors that can affect the processes, such as the temperature, configuration of the plant (C, N and P removal, biological reactor shape) and operating conditions (SRT, HRT, pH etc.)…”

Section: Resultssupporting

confidence: 60%

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Assessment of multiclass pharmaceutical active compounds (PhACs) in hospital WWTP influent and effluent samples by UHPLC-Orbitrap MS: Temporal variation, removals and environmental risk assessment

Kosma

Kapsi

Konstas

et al. 2020

Environmental Research

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Nowadays the occurrence and associated risks of Pharmaceutical Active Compounds (PhACs) in the aquatic environment comprises a major issue. In the present study, a comprehensive survey on contamination profiles, occurrence, removals, temporal variation and ecological risk of multiclass multiresidue PhACs, such as antibiotics, non-steroidal anti-inflammatories, lipid regulators and phsychiatrics, (including past and newly monitored PhACs as well as some of their metabolites) was performed in wastewaters from the WWTP of Ioannina University hospital along one year period on a monthly sampling basis. WWTP influent and effluent samples were analyzed for physicochemical quality parameters and PhACs concentration levels using Ultra High Performance Liquid Chromatography-Orbitrap-Mass Spectrometry (UHPLC-Orbitrap-MS), after Solid Phase Extraction (SPE) through Oasis HLB cartridges. Influent concentrations ranged between < LOQ (Limit of Quantification) for diclofenac and tolfenamic acid and 48586 ng/L for caffeine, while effluent concentrations between < LOQ for tolfenamic acid and simvastatin and 3361 ng/L for caffeine. Removal efficiencies ranged between −132.6% for venlafaxine and 100% for caffeine. Environmental risk assessment by means of Risk Quotient (RQ) for maximum and minimum concentration levels as well as optimized by the frequency of exceeding toxicity threshold values, RQ f , was applied revealing that up to 12 PhACs posed acute toxicity (clofibric acid, fenofibrate, sulfadiazine, sulfamethoxazole, trimethoprim, amitryptiline, fluoxetine, fluvoxamine, norfluoxetine, sertraline, venlafaxine, caffeine) while up to 4 compounds exerted long-term toxicity (sulfamethoxazole, fluoxetine, sertraline, caffeine) at least for one of the studied organisms. Furthermore, mixture RQ MEC/PNEC and RQ STU effect of multiple compounds showed high potential risks of the target groups in some cases, although some contaminants were not included due to lack of available data. Results can be used to prioritization of PhACs and their metabolites for surveillance in receiving water bodies as well as development of knowledge on toxicity and mechanism(s) of action.

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Section: Resultssupporting

confidence: 91%

Section: Resultssupporting

confidence: 60%

Assessment of multiclass pharmaceutical active compounds (PhACs) in hospital WWTP influent and effluent samples by UHPLC-Orbitrap MS: Temporal variation, removals and environmental risk assessment

Kosma

Kapsi

Konstas

et al. 2020

Environmental Research

View full text Add to dashboard Cite

show abstract

“…and personal care products (Bilal, Adeel, Rasheed, Zhao, & Iqbal, 2019; Bilal, Ashraf, Barceló, & Iqbal, 2019; Bilal, Iqbal, & Barceló, 2019; Quesada et al, 2019). With the development of society and the improvement of living standard, the production and consumption of PPCPs are increasing (Papageorgiou, Zioris, Danis, Bikiaris, & Lambropoulou, 2019). PPCPs can enter the environment with domestic wastewater, hospital wastewater, pharmaceutical wastewater, landfill leachate, and animal manure (Li, Gao, et al, 2019; Li, Li, et al, 2019; Li, Zhang, Zeng, et al, 2019; Li, Liu, Zhang, Li, et al, 2019; Li, Zhang, Xia, Wang, et al, 2019; Li, Zhang, Hu, et al, 2019; Li, Sun, Zhang, Feng, et al, 2019; Li, Wang, et al, 2019; Li, Yuan, Gao, Wang, & Sheng, 2019).…”

Section: Overviewmentioning

confidence: 99%

Emerging pollutants—Part II: Treatment

Liu

Zhang

Chang

2020

Water Environment Research

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Emerging pollutants (EPs) refer to a class of pollutants, which are emerging in the environment or recently attracted attention. EPs mainly include pharmaceutical and personal care products (PPCPs), endocrine-disrupting chemicals (EDCs), and antibiotic resistance genes (ARGs). EPs have potential threats to human health and ecological environment. In recent years, the continuous detections of EPs in surface and ground water have brought huge challenges to water treatment and also made the treatment of EPs become an international research hotspot. This paper summarizes some research results on EPs treatment published in 2019. This paper may be helpful to understand the current situations and development trends of EP treatment technologies.

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“…At present, the occurrence of PPCPs in various environmental compartments and their potential ecotoxicological effects have initiated extensive research and policy-making strategies to address the emerging environmental concerns. A number of studies regarding the occurrence, ecotoxicity, and treatment technologies for the removal of PPCPs in wastewater have been conducted in line with the progress in monitoring schemes and analytical techniques [12][13][14][15][16][17][18][19][20]. Despite the growing interest of the scientific community in PPCPs, several knowledge gaps remain due to the relatively small number of compounds being analyzed at different sample matrices.…”

Section: Introductionmentioning

confidence: 99%

Pharmaceutical and Personal Care Products in Different Matrices: Occurrence, Pathways, and Treatment Processes

Reyes

Geronimo

Yano

et al. 2021

Water

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The procedures for analyzing pharmaceuticals and personal care products (PPCPs) are typically tedious and expensive and thus, it is necessary to synthesize all available information from previously conducted research. An extensive collection of PPCP data from the published literature was compiled to determine the occurrence, pathways, and the effectiveness of current treatment technologies for the removal of PPCPs in water and wastewater. Approximately 90% of the compiled published papers originated from Asia, Europe, and the North American regions. The incomplete removal of PPCPs in different water and wastewater treatment processes was widely reported, thus resulting in the occurrence of PPCP compounds in various environmental compartments. Caffeine, carbamazepine, diclofenac, ibuprofen, triclosan, and triclocarban were among the most commonly reported compounds detected in water and solid matrices. Trace concentrations of PPCPs were also detected on plants and animal tissues, indicating the bioaccumulative properties of some PPCP compounds. A significant lack of studies regarding the presence of PPCPs in animal and plant samples was identified in the review. Furthermore, there were still knowledge gaps on the ecotoxicity, sub-lethal effects, and effective treatment processes for PPCPs. The knowledge gaps identified in this study can be used to devise a more effective research paradigm and guidelines for PPCP management.

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Comprehensive investigation of a wide range of pharmaceuticals and personal care products in urban and hospital wastewaters in Greece

Cited by 97 publications

References 53 publications

Assessment of multiclass pharmaceutical active compounds (PhACs) in hospital WWTP influent and effluent samples by UHPLC-Orbitrap MS: Temporal variation, removals and environmental risk assessment

Assessment of multiclass pharmaceutical active compounds (PhACs) in hospital WWTP influent and effluent samples by UHPLC-Orbitrap MS: Temporal variation, removals and environmental risk assessment

Emerging pollutants—Part II: Treatment

Pharmaceutical and Personal Care Products in Different Matrices: Occurrence, Pathways, and Treatment Processes

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