Compressive force promotes chondrogenic differentiation and hypertrophy in midpalatal suture cartilage in growing rats

Mechanical control of stem cell differentiation

“…In classic tissue explants studies, Glucksmann demonstrated ectopic cartilage formation in developing bones when bone explants were trapped between artificial barriers (Glucksmann, 1939). Similarly, in models of the developing jaw, applied compression to the mandible joint led to ectopic cartilage formation on the jaw bones (Hall, 1967;Hall, 1968) and mechanical compression of the midplatal suture reprogrammed mesenchymal stem cell (MSC)-like cells from an osteogenic to a chondrogenic fate (Saitoh et al, 2000).…”

Local RANKL gene transfer to the periodontal tissue accelerates orthodontic tooth movement

“…17 The OF application to the rats did not affect body weights or BMD of tibia. These results suggest that the magnitude of the applied OF in this study was appropriate for the experimental rats.…”

Development and Application of Naturally Renewable Scaffold Materials for Bone Tissue Engineering

“…Nonetheless, MSCs offer tissue engineering a means to fully evaluate biomaterial interactions and afford a cell line capable of undergoing osteogenesis. Typical characterization of mesenchymal stem cells consists of their expression of specific protein markers such as, but not limited to, CD44, CD71, CD90, CD105, CD106, and CD166 (40,52,53), and the ability of the MSCs to differentiate down osteogenic (41,48,(54)(55)(56)(57)(58)(59)(60)(61)(62), adipogenic (41,48,63,64), chondrogenic (3,41,48,(65)(66)(67)(68), fibrogenic (69-71) myogenic (48,57,72), and neuronal (41,46,57,73) lineages. The majority of applications using stem cells for tissue or organ replacement typically use bone marrow-derived mesenchymal stem cells (BMMSCs) (55,66,(70)(71)(72)(74)(75)(76).…”