Bypassing the mathematical complexity of equation‐oriented approaches in predicting the performance of chemical reactors has recently stimulated a significant amount of interest. Among chemical reactors, circulating fluidized bed reactors (CFBRs) have secured an important role in a broad range of applications in energy sectors due to their advantages, including high fluid‐solid contact efficiency, uniform temperature, and enhanced heat and mass transfer rates. Accordingly, modelling and predicting the performance of these reactors is of great importance. In this study, a sequence‐based model was developed to predict the behaviour of CFBRs. Complex phenomena in CFBRs were mimicked by two sub‐models, namely the hydrodynamics module, which addressed the physical changes, and the reaction kinetics module, which described the chemical evolution of species. The performance of the proposed model was validated with a library of catalytic ozone decomposition experimental data in CFBRs. This work introduces a new infrastructure for modelling CFBRs, which may be combined with the current process simulation software, such as Aspen Plus©, for advanced process modelling applications.