Concentrated oleuropein powder from olive leaves using alcoholic extraction and supercritical CO2 assisted extraction

Baldino, Lucia; Porta, Giovanna Della; Osséo, Libero Sesti; Reverchon, Ernesto; Adami, Renata

doi:10.1016/j.supflu.2017.09.026

Cited by 55 publications

(37 citation statements)

References 18 publications

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“…The increase of content of andrographolide in SEDS coprecipitates could be due to extraction of undesired compounds from the crude extract during SEDS co-precipitation, which resulted in an increase of concentration of andrographolide in SEDS coprecipitates compared to the starting material, in this case the crude extract. Similar findings of a concentration effect by the supercritical anti-solvent method, concentrating the active compound from 20% w/w in the crude extract up to 36% w/w in precipitates, has also been reported (Baldino et al, 2018).…”

Section: Physical and Chemical Properties Of Seds Coprecipitatessupporting

confidence: 84%

STABILITY AND TOXICITY PROFILE OF SOLUTION ENHANCED DISPERSION BY SUPERCRITICAL FLUIDS (SEDS) FORMULATED Andrographis paniculata EXTRACT

Lee

Abdullah

Rahman

et al. 2019

Braz. J. Chem. Eng.

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The main objective was to evaluate the stability and toxicity of a Solution Enhanced Dispersion by Supercritical Fluids (SEDS) formulated A. paniculata extract that was intended for food applications. The best formulated SEDS A. paniculata extract with improved dissolution of andrographolide (data not shown) was obtained using 25 mg/mL A. paniculata extract (maceration in acetone) and 6 mg/mL Eudragit L100-55 with acetone as feed solvent at the following SEDS co-precipitation conditions: 150 bar, 40 C, 15 L/min CO 2 flow rate (1 bar, 25 C), 0.5 mL/min liquid feed flow. Sticky A. paniculata extract with 16% w/w andrographolide was transformed into SEDS co-precipitates concentrated with 20.4% w/w andrographolide. Only 20-30% of andrographolide was degraded after two-month storage under 5, 30, 45 C at 75% relative humidity (RH). About 30-60% of andrographolide was degraded after addition into drinking water, orange drink, soybean milk for a day. This would imply its unstable nature after being dispersed and wetted in liquid food. SEDS co-precipitate was found to be practically acetone-free (< 0.1 ppm) by Headspace Gas Chromatography-Mass Spectrometry (GC-MS). This showed the capability of the SEDS process in stripping off acetone. Higher cytotoxic potential of SEDS co-precipitates (LC 50 = 46.46 µg/mL) than extract (LC 50 = 150.45 µg/mL) was observed.

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Section: Physical and Chemical Properties Of Seds Coprecipitatessupporting

confidence: 84%

STABILITY AND TOXICITY PROFILE OF SOLUTION ENHANCED DISPERSION BY SUPERCRITICAL FLUIDS (SEDS) FORMULATED Andrographis paniculata EXTRACT

Lee

Abdullah

Rahman

et al. 2019

Braz. J. Chem. Eng.

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“…Olive leaves in particular represent an important resource of these components whose bioactivity, anti-oxidant, antimicrobial and anti-inflammatory properties have been extensively demonstrated [ 11 , 12 ]. Several conventional (solvent-based) and more modern assisted extraction techniques (ultrasound, microwave, sub- and supercritical fluid extraction, pressurized liquid extraction, pulsed electric field and high voltage electrical discharge, among others) have been tested for their recovery [ 13 , 14 , 15 , 16 , 17 , 18 ]. As stated before, the obtained extracts might have many applications in different fields, including, for instance, food additives and preservatives [ 19 , 20 , 21 ], cosmetics [ 22 ], as well as nutraceuticals and pharmaceuticals [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Establishing the Phenolic Composition of Olea europaea L. Leaves from Cultivars Grown in Morocco as a Crucial Step Towards Their Subsequent Exploitation

et al. 2018

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In Morocco, the recovery of olive agro-industrial by-products as potential sources of high-added value substances has been underestimated so far. A comprehensive quantitative characterization of olive leaves’ bioactive compounds is crucial for any attempt to change this situation and to implement the valorization concept in emerging countries. Thus, the phenolic fraction of olive leaves of 11 varieties (‘Arbequina’, ‘Hojiblanca’, ‘Frantoio’, ‘Koroneiki’, ‘Lechín’, ‘Lucque’, ‘Manzanilla’, ‘Picholine de Languedoc’, ‘Picholine Marocaine’, ‘Picual’ and ‘Verdal’), cultivated in the Moroccan Meknès region, was investigated. Thirty eight phenolic or related compounds (including 16 secoiridoids, nine flavonoids in their aglycone form, seven flavonoids in glycosylated form, four simple phenols, one phenolic acid and one lignan) were determined in a total of 55 samples by using ultrasonic-assisted extraction and liquid chromatography coupled to electrospray ionization-ion trap mass spectrometry (LC-ESI-IT MS). Very remarkable quantitative differences were observed among the profiles of the studied cultivars. ‘Picholine Marocaine’ variety exhibited the highest total phenolic content (around 44 g/kg dry weight (DW)), and logically showed the highest concentration in terms of various individual compounds. In addition, chemometrics (principal components analysis (PCA) and stepwise-linear discriminant analysis (s-LDA)) were applied to the quantitative phenolic compound data, allowing good discrimination of the selected samples according to their varietal origin.

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“…Wax fractionation was performed in the first separator operated at −5 °C and at the same extraction pressure, according to the procedures successfully adopted in several previous works whereas Derris extracts were collected in the second separator, operated at 15 bar and 24 °C. The extraction yield at the end of the second extraction step (in the second separator) was about 6.65% w/w.…”

Section: Resultsmentioning

confidence: 99%

“…Indeed, this can be largely modified by selecting operating temperature and pressure; this characteristic is, in a first approximation, related to the density of SC‐CO 2 at different temperatures and pressures . Shorter processing times than maceration also are possible and the use of organic solvents is avoided . Li et al .…”

Section: Introductionmentioning

confidence: 99%

Extraction of rotenoids from Derris elliptica using supercritical CO₂

Baldino

Scognamiglio

Reverchon

2018

J of Chemical Tech & Biotech

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BACKGROUND: Supercritical (SC)-CO 2 extraction of rotenoids from Derris elliptica roots was proposed using fractional separation of the extracts and operating at increasing pressure. RESULTS:The best processing conditions were found at 200 bar, 40 ∘ C and 1.2 kg h −1 SC-CO 2 flow rate, obtaining a final product with a concentration of 93% w/w of rotenone and rotenoids, and a yield of active principles of 6.70% w/w with respect to the vegetable matrix. Very small quantities of waxes were found, up to 0.05% w/w; this result can be explained considering the reduced surface-to-volume ratio of this vegetable material. CONCLUSION: Extraction kinetics data confirmed that, in this case, the extraction process was controlled by solubility limitation of the active compounds in the supercritical solvent.

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Concentrated oleuropein powder from olive leaves using alcoholic extraction and supercritical CO2 assisted extraction

Cited by 55 publications

References 18 publications

STABILITY AND TOXICITY PROFILE OF SOLUTION ENHANCED DISPERSION BY SUPERCRITICAL FLUIDS (SEDS) FORMULATED Andrographis paniculata EXTRACT

STABILITY AND TOXICITY PROFILE OF SOLUTION ENHANCED DISPERSION BY SUPERCRITICAL FLUIDS (SEDS) FORMULATED Andrographis paniculata EXTRACT

Establishing the Phenolic Composition of Olea europaea L. Leaves from Cultivars Grown in Morocco as a Crucial Step Towards Their Subsequent Exploitation

Extraction of rotenoids from Derris elliptica using supercritical CO₂

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Concentrated oleuropein powder from olive leaves using alcoholic extraction and supercritical CO2 assisted extraction

Cited by 55 publications

References 18 publications

STABILITY AND TOXICITY PROFILE OF SOLUTION ENHANCED DISPERSION BY SUPERCRITICAL FLUIDS (SEDS) FORMULATED Andrographis paniculata EXTRACT

STABILITY AND TOXICITY PROFILE OF SOLUTION ENHANCED DISPERSION BY SUPERCRITICAL FLUIDS (SEDS) FORMULATED Andrographis paniculata EXTRACT

Establishing the Phenolic Composition of Olea europaea L. Leaves from Cultivars Grown in Morocco as a Crucial Step Towards Their Subsequent Exploitation

Extraction of rotenoids from Derris elliptica using supercritical CO2

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Extraction of rotenoids from Derris elliptica using supercritical CO₂