Concentration of di(2-ethylhexyl) phthalate (DEHP) in foods and its dietary exposure in China

Sui, Haixia; Zhang, Lei; Wu, Pinggu; Song, Yan; Lyu, Yong; Yang, Dajin; Jiang, Dazhi; Liu, Zhaoping

doi:10.1016/j.ijheh.2014.02.006

Cited by 70 publications

(21 citation statements)

References 32 publications

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“…China (Sui et al, 2014). However, DEHP exposure in countries like Cambodia (Cheng et al, 2013) and Germany (Heinemeyer et al, 2013) were presented one order of magnitude higher than the Tarragona's results.…”

Section: Dietary Exposure Compared To Other Countriesmentioning

confidence: 68%

Prenatal exposure estimation of BPA and DEHP using integrated external and internal dosimetry: A case study

Martínez

Rovira

Sharma

et al. 2017

Environmental Research

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Prenatal exposure to Endocrine disruptors (EDs), such as Bisphenol A (BPA) and di (2-ethylhexyl) phthalate (DEHP), has been associated with obesity and diabetes diseases in childhood, as well as reproductive, behavioral and neurodevelopment problems. The aim of this study was to estimate the prenatal exposure to BPA and DEHP through food consumption for pregnant women living in Tarragona County (Spain). Probabilistic calculations of prenatal exposure were estimated by integrated external and internal dosimetry modelling, physiologically based pharmacokinetic (PBPK) model, using a Monte-Carlo simulation. Physical characteristic data from the cohort, along with food intake information from the questionnaires (concentrations of BPA and DEHP in different food categories and the range of the different food ratios), were used to estimate the value of the total dietary intake for the Tarragona pregnancy cohort. The major contributors to the total dietary intake of BPA were canned fruits and vegetables, followed by canned meat and meat products. In turn, milk and dairy products, followed by ready to eat food (including canned dinners), were the most important contributors to the total dietary intake of DEHP. Despite the dietary variations among the participants, the intakes of both chemicals were considerably lower than their respective current tolerable daily intake (TDI) values established by the European Food Safety Authority (EFSA). Internal dosimetry estimates suggest that the plasma concentrations of free BPA and the most important DEHP metabolite, mono (2-ethylhexyl) phthalate (MEHP), in pregnant women were characterized by transient peaks (associated with meals) and short half-lives (< 2h). In contrast, fetal exposure was characterized by a low and sustained basal BPA and MEHP concentration due to a lack of metabolic activity in the fetus. Therefore, EDs may have a greater effect on developing organs in young children or in the unborn child.

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Section: Dietary Exposure Compared To Other Countriesmentioning

confidence: 68%

Prenatal exposure estimation of BPA and DEHP using integrated external and internal dosimetry: A case study

Martínez

Rovira

Sharma

et al. 2017

Environmental Research

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“…The tea consumption data were obtained from the China National Nutrient and Health Survey conducted in 2002 [ 36 ]. This survey used multistage, random cluster sampling, which was conducted in 132 sampling locations in 31 provinces in China, using three consecutive, 24-h dietary recall face-to-face interviews, including two weekdays and one weekend, holidays excluded.…”

Section: Methodsmentioning

confidence: 99%

Estimated assessment of cumulative dietary exposure to organophosphorus residues from tea infusion in China

Cao

Yang

Zhu

et al. 2018

Environ Health Prev Med

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BackgroundChina has the world’s largest tea plantation area in the world. To sustain high yields of the tea, multiple pesticides are used on tea crops to control pests. Organophosphorus (OP) pesticides are among the most widely used types of agricultural pesticides in China. As tea is a significant potential source of exposure to pesticide residues, the public concern has increased in relation to pesticide residues found in tea in China. The aim of the study was to estimate cumulative dietary exposure to OP residues from tea infusion for Chinese tea consumers to determine whether exposure to OP residues from tea infusion is a cause of health concern for tea consumers in China.MethodsOP residue data were obtained from the China National Monitoring Program on Food Safety (2013–2014), encompassing 1687 tea samples from 12 provinces. Tea consumption data were obtained from the China National Nutrient and Health Survey (2002), comprising 506 tea consumers aged 15–82 years. The transfer rates of residues from tea leaves into tea infusions were obtained from the literature. The relative potency factor (RPF) approach was used to estimate acute cumulative exposure to 20 OP residues from tea infusion using methamidophos as the index compound. Dietary exposure was calculated in a probabilistic way.ResultsFor tea consumers, the mean and the 99.9th percentile (P99.9) of cumulative dietary exposure to OP residues from tea infusion equalled 0.08 and 1.08 μg/kg bw/d. When compared with the acute reference dose (ARfD), 10 μg/kg bw/d for methamidophos, this accounts for 0.8 and 10.8% of the ARfD.ConclusionsEven when considering OP residues from vegetables, fruits and other foods, there are no health concerns based on acute dietary exposure to OP residues from tea infusion. However, it is necessary to strengthen the management of the OP pesticides used on tea in China to reduce the risk of chronic dietary exposure to OPs from tea infusion.Electronic supplementary materialThe online version of this article (10.1186/s12199-018-0696-1) contains supplementary material, which is available to authorized users.

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“…In 2014, Sui et al [67] investigated the dietary exposure to DEHP in China. Their work showed that mean dietary intakes of DEHP (mg/kgbw/d) in children, adults and the general population were 4.51, 2.03 and 2.34, respectively.…”

Section: Properties and Toxicitiesmentioning

confidence: 99%

Recent advances in analysis of phthalate esters in foods

Yang

Wang

et al. 2015

TrAC Trends in Analytical Chemistry

130

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Concentration of di(2-ethylhexyl) phthalate (DEHP) in foods and its dietary exposure in China

Cited by 70 publications

References 32 publications

Prenatal exposure estimation of BPA and DEHP using integrated external and internal dosimetry: A case study

Prenatal exposure estimation of BPA and DEHP using integrated external and internal dosimetry: A case study

Estimated assessment of cumulative dietary exposure to organophosphorus residues from tea infusion in China

Recent advances in analysis of phthalate esters in foods

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