2019
DOI: 10.3390/ijerph16132303
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Concentrations of Lead, Mercury, Arsenic, Cadmium, Manganese, and Aluminum in Blood of Romanian Children Suspected of Having Autism Spectrum Disorder

Abstract: Environmental exposure to lead (Pb), mercury (Hg), arsenic (As), cadmium (Cd), manganese (Mn), and aluminum (Al) has been associated with neurodevelopmental disorders including autism spectrum disorder (ASD). We conducted a pilot study during May 2015–May 2107 to estimate blood concentrations of six metals (Pb, Hg, As, Cd, Mn, and Al) and identify their associated factors for children with ASD or suspected of having ASD in Romania. Sixty children, age 2–8 years, were administered versions of ADOS or ADI-R tran… Show more

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Cited by 21 publications
(7 citation statements)
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“…Finally, in the development of the second phase of the project, there were limited financial resources to continue expanding human and logistic resources, biomonitoring of exposure levels, and consequently, neuropsychological evaluation. Now, an important aspect to consider concerning our first limitation is, precisely, that we have also found other similar empirical studies published in the last 5 years which constituted important contributions in broadening the discussion, despite having a reduced number of participants, as shown by Manju et al (2017) who studied a sample of 20 subjects, Golding et al (2018) with 45 participants and Hessabi et al (2019) with a total N of 60.…”
mentioning
confidence: 76%
“…Finally, in the development of the second phase of the project, there were limited financial resources to continue expanding human and logistic resources, biomonitoring of exposure levels, and consequently, neuropsychological evaluation. Now, an important aspect to consider concerning our first limitation is, precisely, that we have also found other similar empirical studies published in the last 5 years which constituted important contributions in broadening the discussion, despite having a reduced number of participants, as shown by Manju et al (2017) who studied a sample of 20 subjects, Golding et al (2018) with 45 participants and Hessabi et al (2019) with a total N of 60.…”
mentioning
confidence: 76%
“…ICP-MS can be used to analyze blood with less sample preparation mainly involving matrix solubilization with acidic or alkaline solutions, which can be accelerated by microwave irradiation[ 44 ]. Table 1 Lists a few studies on measurement of Hg in blood by ICP-MS[ 30 , 32 , 34 , 45 ]. The United States CDC uses this technique to measure blood Hg after solubilizing the matrix with a solution of tetramethylammonium hydroxide[ 46 ].…”
Section: Analytical Methods For Blood Hg and Pb Measurement In Clinical Studiesmentioning
confidence: 99%
“…A method by the U.S. CDC measures Pb in whole blood using ICP-MS after simple dilution[ 58 ]. The use of ICP-MS has also been widely reported to evaluate the relationship between blood Pb levels and ASD, see Table 1 [ 30 , 32 , 34 , 37 , 45 , 59 ]. Portable and easy-to-operate devices using anodic stripping voltammetry technology are also available to measure Pb at point of care on a small amount of blood.…”
Section: Analytical Methods For Blood Hg and Pb Measurement In Clinical Studiesmentioning
confidence: 99%
“…Although the global and nationwide prevalence and burden of HMs are not available, many regional studies [19][20][21][22][23][24][25] have estimated the risk of heavy metal exposure in humans. In the DRC, little is known about the risk of heavy metal exposure in children and its spatial distribution.…”
Section: Introductionmentioning
confidence: 99%