Concentrations of organohalogen compounds and titres of antibodies to Epstein-Barr virus antigens and the risk for non-Hodgkin lymphoma

Hardell, Karin; Carlberg, Michael; Hardell, Lennart; Björnfoth, Helén; Jogsten, Ingrid Ericson; Eriksson, M.; Bavel, Bert van; Lindström, Gunilla

doi:10.3892/or_00000389

Cited by 38 publications

(63 citation statements)

References 25 publications

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“…Of these 11 studies, 7 measured chlordane/heptachlor or their metabolite (eg, oxychlordane, heptachlor epoxide) concentrations. Four studies 55,60,126,127 observed positive associations between chlordanes and NHL, whereas the 3 other studies did not observe an association. 48,54,58 In addition to oxychlordane and related compounds (eg, heptachlor), 10 of these studies examined the association between concentrations of DDT or its metabolite, DDE, and NHL.…”

Section: Prostate Cancermentioning

confidence: 89%

“…48,54,58 In addition to oxychlordane and related compounds (eg, heptachlor), 10 of these studies examined the association between concentrations of DDT or its metabolite, DDE, and NHL. Five studies 48,55,60,126,127 demonstrated either positive or suggestive associations, whereas the other 5 studies 46,54,56,59,131 did not observe an association between DDT or DDE and NHL.…”

Section: Prostate Cancermentioning

confidence: 98%

“…For instance, only one study 127 assayed for mirex, finding a positive association (OR, 1.44; 95% CI, 1.08-1.92). Conversely, HCB was assessed in 8 of these studies, 46,48,54,55,58,60,126,127 of which only one observed an association. b-Hexachlorocyclohexane concentrations were positively associated with NHL in only 2 52,123 of the 6 studies that measured it in either plasma, serum, or adipose tissue.…”

Section: Prostate Cancermentioning

confidence: 99%

“…The vast majority of these studies focused on OC insecticides (11 of 15 studies) and used serum, 48,58,131 plasma, 46,[54][55][56]59 or adipose tissue 53,60,126 concentrations of the OC compounds as the estimate of exposure. Of these 11 studies, 7 measured chlordane/heptachlor or their metabolite (eg, oxychlordane, heptachlor epoxide) concentrations.…”

Section: Prostate Cancermentioning

confidence: 99%

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Increased cancer burden among pesticide applicators and others due to pesticide exposure

Alavanja

Ross

Bonner

2013

CA A Cancer J Clinicians

296

213

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A growing number of well-designed epidemiological and molecular studies provide substantial evidence that the pesticides used in agricultural, commercial, and home and garden applications are associated with excess cancer risk. This risk is associated both with those applying the pesticide and, under some conditions, those who are simply bystanders to the application. In this article, the epidemiological, molecular biology, and toxicological evidence emerging from recent literature assessing the link between specific pesticides and several cancers including prostate cancer, non-Hodgkin lymphoma, leukemia, multiple myeloma, and breast cancer are integrated. Although the review is not exhaustive in its scope or depth, the literature does strongly suggest that the public health problem is real. If we are to avoid the introduction of harmful chemicals into the environment in the future, the integrated efforts of molecular biology, pesticide toxicology, and epidemiology are needed to help identify the human carcinogens and thereby improve our understanding of human carcinogenicity and reduce cancer risk. CA Cancer J Clin 2013;63:120-142.

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Section: Prostate Cancermentioning

confidence: 89%

Section: Prostate Cancermentioning

confidence: 98%

Section: Prostate Cancermentioning

confidence: 99%

Section: Prostate Cancermentioning

confidence: 99%

See 2 more Smart Citations

Increased cancer burden among pesticide applicators and others due to pesticide exposure

Alavanja

Ross

Bonner

2013

CA A Cancer J Clinicians

296

213

View full text Add to dashboard Cite

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“…We found evidence of some confounding by NDL-PCBs, although the risk of NHL associated with TEQ concentrations remained elevated. Epstein-Barr virus (EBV) serology was not performed because an interaction between EBV and organochlorines (Rothman et al, 1997;Hardell et al, 2001;Hardell et al, 2009) would not have been apparent, due to the limited number of participants.…”

Section: Discussionmentioning

confidence: 99%

Increased risk of non-Hodgkin lymphoma and serum organochlorine concentrations among neighbors of a municipal solid waste incinerator

Viel¹,

Floret²,

Deconinck³

et al. 2011

Environment International

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Organochlorine chemicals may contribute to an increased risk of non-Hodgkin lymphoma (NHL) within nonoccupationally exposed populations. Among these chemicals, dioxins and furans were mainly released by municipal solid waste incinerators (MSWIs) until a recent past in France, a source of exposure that is of public concern. We investigated organochlorines and the risk of NHL among neighbors of a French MSWI with high levels of dioxin emissions (Besançon, France), using serum concentrations to assess exposure. The study area consisted of three electoral wards, containing or surrounding the MSWI. Pesticides, dioxins, furans, and polychlorinated biphenyls (PCBs) were measured in the serum of 34 newly diagnosed NHL cases (2003)(2004)(2005) and 34 controls. Risks of NHL associated with each lipid-corrected serum concentration were estimated using exact logistic regression. The pesticides β-hexachlorocyclohexane (odds ratio [OR] = 1.05, 95% confidence interval [CI] = 1.00-1.12, per 10 ng/g lipid) and p,p' dichloro-diphenyl-trichloroethane (DDT) (OR = 1.20, 95% CI = 1.01-1.45, per 10 ng/g lipid) were associated with NHL risk. Evidence indicated an increased NHL risk associated with cumulative WHO 1998 -toxic equivalency factor (TEQ) concentrations (dioxins, OR = 1.12, 95% CI = 1.03-1.26; furans, OR = 1.16, 95% CI = 1.03-1.35; dioxin-like PCBs, OR = 1.04, 95% CI = 1.00-1.07; and total TEQ, OR = 1.04, 95% CI = 1.01-1.05), as well as with non dioxin-like PCBs (OR = 1.02, 95% CI = 1.01-1.05, per 10 ng/g lipid). Most congener-specific associations were statistically significant. This study provides strong and consistent support for an association between serum cumulative WHO 1998 -TEQ concentrations, at levels experienced by people residing in the vicinity of a polluting MSWI, and risk of NHL.

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Exposure to Polybrominated Diphenyl Ethers and Risk of All-Cause and Cause-Specific Mortality

Liu,

Lehmler,

et al. 2024

JAMA Netw Open

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ImportancePolybrominated diphenyl ethers (PBDEs) are an important group of persistent organic pollutants with endocrine-disrupting properties. However, prospective cohort studies regarding the association of PBDE exposure with long-term health outcomes, particularly mortality, are lacking.ObjectiveTo examine the association of environmental exposure to PBDEs with risk of all-cause and cause-specific mortality.Design, Setting, and ParticipantsThis nationally representative cohort study used data from the National Health and Nutrition Examination Survey 2003 to 2004 and linked mortality information through December 31, 2019. Adults aged 20 years or older with available data on PBDE measurements and mortality were included. Statistical analysis was performed from February 2022 to April 2023.ExposuresPBDE analytes in serum samples were measured using solid phase extraction and isotope dilution gas chromatography high-resolution mass spectrometry.Main Outcomes and MeasuresAll-cause mortality, cancer mortality, and cardiovascular mortality.ResultsThis study included 1100 participants (mean [SE] age, 42.9 [0.6] years; proportion [SE] female, 51.8% [1.6%]; proportion [SE] Hispanic, 12.9% [2.7%]; proportion [SE] non-Hispanic Black, 10.5% [1.6%]; proportion [SE] non-Hispanic White, 70.8% [3.7%]; proportion [SE] other race and ethnicity, 5.8% [1.1%]). During 16 162 person-years of follow-up (median [IQR] follow-up, 15.8 [15.2-16.3] years; maximum follow-up, 17 years), 199 deaths occurred. Participants with higher serum PBDE levels were at higher risk for death. After adjustment for age, sex, and race and ethnicity, lifestyle and socioeconomic factors, and body mass index, participants with the highest tertile of serum PBDE levels had an approximately 300% increased risk of cancer mortality (HR, 4.09 [95% CI, 1.71-9.79]) compared with those with the lowest tertile of serum PBDE levels. No significant association of PBDE exposure with all-cause mortality (HR, 1.43 [95% CI, 0.98-2.07]) or cardiovascular mortality (HR, 0.92 [95% CI, 0.41-2.08]) was observed.Conclusions and RelevanceIn this nationally representative cohort study, PBDE exposure was significantly associated with an increased risk of cancer mortality. Further studies are needed to replicate the findings and determine the underlying mechanisms.

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Concentrations of organohalogen compounds and titres of antibodies to Epstein-Barr virus antigens and the risk for non-Hodgkin lymphoma

Cited by 38 publications

References 25 publications

Increased cancer burden among pesticide applicators and others due to pesticide exposure

Increased cancer burden among pesticide applicators and others due to pesticide exposure

Increased risk of non-Hodgkin lymphoma and serum organochlorine concentrations among neighbors of a municipal solid waste incinerator

Exposure to Polybrominated Diphenyl Ethers and Risk of All-Cause and Cause-Specific Mortality

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