Abstract. Exposure to some pesticides and persistent organic pollutants (POPs) has been indicated to be a risk factor for non-Hodgkin's lymphoma (NHL). Epstein-Barr virus (EBV) has been associated with some subgroups of NHL. In a previous study we found an interaction between high concentrations of some POPs and titres of antibodies to EBV early antigen (EA IgG) in relation to NHL. In the present study we measured lipid adjusted plasma concentrations of 35 congeners of polychlorinated biphenyls (PCB), p,p'-dichlorodiphenyldichloroethyelene (p,p'-DDE), hexachlorobenzene (HCB), seven subgroups of chlordanes (cisheptachlorepoxide, cis-chlordane, trans-chlordane, oxychlordane, MC6, trans-nonachlordane, cis-nonachlordane) and one polybrominated diphenylether (PBDE) congener (no. 47) in 99 cases with NHL and 99 population based controls. Odds ratios (OR) for NHL were estimated. Sum of PCBs > median in the controls gave odds ratio (OR) 2.0, 95% confidence interval (CI) 0.99-3.9. High sum of chlordanes yielded OR 2.3, 95% CI 1.2-4.5. An interaction with EBV EA IgG was found. High sum of PCB gave OR 5.2, 95% CI 1.9-14 in the group with EA IgG > 40. Similarly HCB yielded OR 5.3, 95% CI 1.9-15, pp'-DDE gave OR 3.3, 95% CI 1.4-7.7 and sum of chlordanes yielded OR 6.8, 95% CI 2.3-20, whereas no association was found with PBDE. In summary, this study confirmed an association between certain POPs and NHL with an interaction with titre of IgG antibody to EBV EA.

No abstract

No abstract

Hairy cei leukemia (HCL) is a rare chronic B-cell malignancy that, according to modern dassifications., is a subgroup of non-Hodgkin lymphomas (NHLs). A rapid increase in incidence of NHL has been reported mi many countries. The reasons for this increase are largely unknown, but exposure to organochlorines has been suggted as a risk factor. Epstein-Barr virus is a human herpesvrus that has'been associated with certain subgroups of NHL In this study, we measured lipid adjusted blood concentrations (

Hairy cei leukemia (HCL) is a rare chronic B-cell malignancy that, according to modern dassifications., is a subgroup of non-Hodgkin lymphomas (NHLs). A rapid increase in incidence of NHL has been reported mi many countries. The reasons for this increase are largely unknown, but exposure to organochlorines has been suggted as a risk factor. Epstein-Barr virus is a human herpesvrus that has'been associated with certain subgroups of NHL In this study, we measured lipid adjusted blood concentrations (in nanogr per gmm) of 36 congeners of polychlorinated b:iphenyls (PCBs), p,p'.-dichlorodiphenyldichloroethylene (p,p'-DDE), hexachlorobenzene (HCB), and four subgroups of chlorines (trans-nonachlor, cis-nonachlor, MC6, and oxychlordane) in incident cases of HCL and controls from the general population. We obtained results on organochiorines and antibodies for 54 cases and 54 controls. Titers of antibodies to the Epstein-Barr early antigen and Epstein-Barr nlear antigen, measured as P107, were correlated to concentrations of organochlorines to evauate the possibility of an interaction between these factors in the pathogenes of HCL. We found no sficant difference in lipid-adjusted blood concentrations oftotal PCBs, pAp-DDE, HCB, or the sum ofthee chlordanes between cases and controls. Titers of antibodies to Epstei-Barr early antigen IgG. 40 were correlated to an increased risk for HCL. This risk was farther increased in those with. a level above the median value of p,p'-DDE, HCB, or the sum of the chlordanessgs t a-nS interaction between Epstein-Barr virus and a higher cooncentration of these chemicals. We also found increased risk for the sum of