Decreased survival in pancreatic cancer patients with high concentrations of organochlorines in adipose tissue

Hardell, Lennart; Carlberg, Michael; Hardell, Karin; Björnfoth, Helén; Wickbom, G; Ionescu, M; Bavel, Bert van; Lindström, Gunilla

doi:10.1016/j.biopha.2007.04.006

Cited by 27 publications

(18 citation statements)

References 21 publications

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“…A statistically significant association was found between BDE-47 (medians both below and over 1.8 ng/g fat) and titres of EBV EA IgG over 40 for diffuse large B-cell NHL subtype. No statistically significant association was found for survival for pancreatic cancer (p=0.09) and no statistically significant association for risk of pancreatic cancer (OR 3.9 95 % CI 0.93-16.3) and tissue concentrations of ΣPBDE (Hardell et al, 2007).…”

Section: Cancermentioning

confidence: 84%

Scientific Opinion on Polybrominated Diphenyl Ethers (PBDEs) in Food

2011

EFS2

197

147

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EFSA was asked by the European Commission to deliver a scientific opinion on polybrominated diphenyl ethers (PBDEs) in food. PBDEs are additive flame retardants which are applied in plastics, textiles, electronic castings and circuitry. PBDEs are ubiquitously present in the environment and likewise in biota and in food and feed. Data from the analysis of 19 PBDE congeners in 3,971 food samples were provided to EFSA by 11 European countries. Eight congeners were considered by the Panel on Contaminants in the Food Chain (CONTAM Panel) to be of primary interest: . The highest dietary exposure is to . Toxicity studies were carried out with technical PBDE mixtures or individual congeners. Main targets were the liver, thyroid hormone homeostasis and the reproductive and nervous system. PBDEs cause DNA damage through the induction of reactive oxygen species. The Panel identified effects on neurodevelopment as the critical endpoint, and derived benchmark doses (BMDs) and their corresponding lower 95 % confidence limit for a benchmark response of 10 %, BMDL 10 s, for a number of PBDE congeners: BDE-47, 309 μg/kg b.w.; BDE-99, 12 μg/kg b.w.; BDE-153, 83 μg/kg b.w.; BDE-209, 1,700 μg/kg b.w. Due to the limitations and uncertainties in the current database, the Panel concluded that it was inappropriate to use these BMDLs to establish health based guidance values, and instead used a margin of exposure (MOE) approach for the health risk assessment. Since elimination characteristics of PBDE congeners in animals and humans differ considerably, the Panel used the body burden as starting point for the MOE approach. The CONTAM Panel concluded that for BDE-47, -153 and -209 current dietary exposure in the EU does not raise a health concern. For BDE-99 there is a potential health concern with respect to current dietary exposure. 4 The term "intra-species" has been replaced by "inter-species" in the Summary and in Chapter 9.1. The chemical stability of the PBDE congeners varies with the individual structure. In general PBDE congeners with up to three bromine substituents and those with nine or ten bromine substituents are more sensitive to abiotic transformations. PBDE congeners with four to eight bromine substituents show the highest stability. PBDE congeners are particularly susceptible to photolysis, reductive debromination and radical reactions whereas they are less susceptible to oxidation and hydrolysis. In general, PBDE congeners are persistent and bioaccumulative with the exception of BDE-209 bioaccumulative properties of which seem to be species dependent. BDE-209 undergoes debromination reactions both in the abiotic environment and in biota, leading to formation of PBDE congeners containing seven to nine bromine atoms. © European Food SafetyBased on the composition of the technical PBDE mixtures, occurrence in the environment and in food, the Panel on Contaminants in the Food Chain (CONTAM Panel) considered the following eight PBDE congeners to be of primary interest: which are relevant for dietary PBDE exposur...

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Section: Cancermentioning

confidence: 84%

Scientific Opinion on Polybrominated Diphenyl Ethers (PBDEs) in Food

2011

EFS2

197

147

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“…The levels of PBBs in kidney, liver, and lung tissue (181-192 ng/g lipid) [74] were 10 times those reported for the United States general population (3-8 ng/g lipid) [75]. The PBDE levels (174-182 ng/g lipid) [74] were comparable to those for the general population of the United States (23-399 ng/g lipid) [75][76][77], but significantly higher than those in the populations of Japan (0.7-2.9 ng/g lipid) [78], Singapore (0.5-12 ng/g lipid) [79], and Europe (3.9-18 ng/g lipid) [80][81][82][83][84]. Furthermore, the levels of PCBs (257-399 ng/g lipid) were similar to those reported in the populations of European industrialized countries [74].…”

Section: Human Exposure To Phcs From E-waste In Chinamentioning

confidence: 86%

Environmental and human exposure to persistent halogenated compounds derived from e‐waste in China

Zeng

Tao

et al. 2010

Enviro Toxic and Chemistry

116

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Various classes of persistent halogenated compounds (PHCs) can be released into the environment due to improper handling and disposal of electronic waste (e-waste), which creates severe environmental problems and poses hazards to human health as well. In this review, polybrominated diphenyl ethers (PBDEs), polybrominated biphenyls (PBBs), tetrabromobisphenol A (TBBPA), polybrominated phenols (PBPs), polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs), polybrominated dibenzo-p-dioxins and dibenzofurans (PBDD/Fs), and chlorinated polycyclic aromatic hydrocarbons (ClPAHs) are the main target contaminants for examination. As the world's largest importer and recycler of e-waste, China has been under tremendous pressure to deal with this huge e-waste situation. This review assesses the magnitude of the e-waste problems in China based on data obtained from the last several years, during which many significant investigations have been conducted. Comparative analyses of the concentrations of several classes of toxic compounds, in which e-waste recycling sites are compared with reference sites in China, have indicated that improper e-waste handling affects the environment of dismantling sites more than that of control sites. An assessment of the annual mass loadings of PBDEs, PBBs, TBBPA, PBPs, PCDD/Fs, and ClPAHs from e-waste in China has shown that PBDEs are the dominant components of PHCs in e-waste, followed by ClPAHs and PCDD/Fs. The annual loadings of PBDEs, ClPAHs, and PCDD/Fs emission were estimated to range from 76,200 to 182,000, 900 to 2,000 and 3 to 8 kg/year, respectively. However, PCDD/Fs and ClPAHs should not be neglected because they are also primarily released from e-waste recycling processes. Overall, the magnitude of human exposure to these toxics in e-waste sites in China is at the high end of the global range.

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“…Lee et al, (2010) suggested that some POPs may be associated to type 2 Diabetes. Many other harmful aspects of POPs on human beings, are presented in literature, such as tumour promoter (Shin et al, 2010), pancreatic cancer (Hardell et al, 2007), cardiovascular diseases (Lind et al, 2004) and neurological problems (Weiss, 2011).…”

Section: Polychlorinated Biphenyls (Pcbs)mentioning

confidence: 99%

Production of Persistent Organic Pollutants from Cement Plants

Rodrigues¹

2012

Environmental Contamination

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Decreased survival in pancreatic cancer patients with high concentrations of organochlorines in adipose tissue

Cited by 27 publications

References 21 publications

Scientific Opinion on Polybrominated Diphenyl Ethers (PBDEs) in Food

Scientific Opinion on Polybrominated Diphenyl Ethers (PBDEs) in Food

Environmental and human exposure to persistent halogenated compounds derived from e‐waste in China

Production of Persistent Organic Pollutants from Cement Plants

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