Concept of Polycystic Ovarian Syndrome: Perspectives of Ayurveda and Modern Science

Abstract

Non enzymatic glycation is a chain reaction between reducing sugars and the free amino groups of proteins, involved in severity of diabetes and diabetic complications. Litchi chinensis used as consumed fruit and as a drug to treat certain diseases. In this study the antioxidative effects of L.chinensis and also its effect against protein oxidation and advanced glycation end products. The antioxidant potential of aqueous fruit pericarp extract of L.chinensis (APLC) was evaluated in vitro using a model of fructose-mediated protein glycation. The antioxidant activity of APLC conducted for superoxide, hydroxyl, hydrogen peroxide, nitric oxide radical scavenging activities and also demonstrated antioxidant activity with Fe+2 chelating activity, ferric reducing antioxidant power (FRAP) and Trolox equivalent antioxidant capacity (TEAC) were applied. Fructose (100mM) increased fluorescence intensity of glycated bovine serum albumin (BSA) in terms of total AGEs during 21 days of exposure. Moreover, fructose caused more protein carbonyl (PCO) formation in native BSA. The APLC prevents oxidative protein damages including effect on PCO formation which are believed to form under the glycoxidation process. The APLC at different concentrations (25-250µg/ml) has significantly decreased the formation of AGEs in term of the fluorescence intensity of glycated BSA.

Comparative Study of Pathogenesis of Pcos and Its Correlation Cited in Various Ayurvedic and Modern Research Papers Pub-Lished

“…The predominance of Vata is manifested as painful menses, scanty or less menstrual blood and severe menstrual irregularities. 12 Ayurveda suggest that this is a Vata type disorder (Apan Vayu) through the involvement of other Dosha can be there but in some measure because the gynecological disorder is mainly supposed to be due to vitiation of Vata. PCOS is a disorder involving Pitta, Kapha, Medas, Ambuvahastrotasa and Artava Dhatu.…”