Conceptos y aplicaciones de la ingeniería tisular en Otorrinolaringología

Ribeiro, Leandro; Castro, Eugénia; Ferreira, Manuela; Helena, Diamantino; Robles, Raquel; Almeida, Ana; Condé, Artur

doi:10.1016/j.otorri.2014.03.007

Cited by 4 publications

(1 citation statement)

References 40 publications

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“…Tissue bioengineering seeks the combination of scaffolds, cells and biologically active molecules (1)(2)(3)(4), with the aim to restore or maintain the normal function of an organ or tissue (2,(5)(6)(7). The regeneration is then achieved with a threedimensional construct (the scaffold), designed to support the infiltration of new cells, their growth and differentiation, and to enhance new tissue development.…”

Section: Introductionmentioning

confidence: 99%

Physicochemical and Tissue Response of PLA Nanofiber Scaffolds Sterilized by Different Techniques

Mendieta-Barrañon

Chanes-Cuevas

Álvarez-Pérez

et al. 2018

Odovtos - Int J Dent Sc

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In recent years, tissue engineering has evolved considerably, due to the problems in the biomedical area concerning tissue regeneration therapies. Currently, work has been focused on the synthesis and physicochemical characterization of poly lactic acid scaffolds, a synthetic polyester that has been extensively study for its excellent biocompatibility and biodegradability. Moreover, sterilization strategies of scaffold are a crucial step for its application in tissue regeneration, however, the sterilization process have to maintain the structural and biochemical properties of the scaffold. Therefore, it is very important to carry out studies on the sterilization methods of the sample’s material, since translational medicine is intended for in vivo applications. The aim of the present study was designed to analyze the effects of different sterilization techniques, i.e. ethylene oxide (ETO), gamma radiation (GR) and hydrogen peroxide-based plasma (H2O2) in biodegradable PLA scaffolds, and to determine the best sterilization technique to render a sterile product with minimal degradation and deformation, and good tissue response. Analysis of surface morphology showed that ETO and GR modified the PLA scaffolds without any change in its chemical composition. Moreover, the histological response showed that the scaffolds are biocompatible and those sterilized by GR showed a more severe inflammatory response, accompanied with the presence of giant foreign body cells. In conclusion, the results show that among sterilization techniques used in the preset study, the best results were observed with H2O2 sterilization, since it did not significantly modify the surface structure of the PLA fibers and their in vivo response did not cause an unfavorable tissue reaction.

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Section: Introductionmentioning

confidence: 99%

Physicochemical and Tissue Response of PLA Nanofiber Scaffolds Sterilized by Different Techniques

Mendieta-Barrañon

Chanes-Cuevas

Álvarez-Pérez

et al. 2018

Odovtos - Int J Dent Sc

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Tissue engineering in otorhinolaryngology: A knowledge‐based analysis

Padilla‐Cabello,

Martin‐Piedra,

Santisteban‐Espejo

et al. 2023

Laryngoscope Investig Oto

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ObjectiveTo analyze the impact, performance, degree of specialization, and collaboration patterns of the worldwide scientific production on tissue engineering in otorhinolaryngology at the level of countries and institutions.MethodsTwo different techniques were used, performance and science mapping analyses, using as samples all the available documents regarding tissue engineering focused on otorhinolaryngology applications. The dataset was retrieved from the Core Collection of the Web of Science database from 1900 to 2020. Social structure was analyzed using science mapping analysis with VOSviewer software.ResultsThe United States was the main producer, followed by Germany, and Japan. Malaysia and Germany had the highest Relative Specialization Index, indicating their greater relative interest in this area compared to other countries. The social structure analysis showed that the United States and Germany had significant co‐authorship relationships with other countries. The University of California System, Kyoto University, and Harvard University were the leading institutions producing literature in this field. These latter two institutions showed the largest number of collaborations, although most of them were with institutions within their own country. There was a lack of connections between different communities of research.ConclusionThe United States is the main country driving progress in this research area, housing the most notable institutions. However, significant collaborations between these research centers are currently lacking. Encouraging greater cooperation among these institutions and their researchers would promote the exchange of knowledge, ultimately facilitating and accelerating advancements in this field.

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Ear Tissue Engineering

Mota¹,

Danti²

2019

Comprehensive Biotechnology

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Conceptos y aplicaciones de la ingeniería tisular en Otorrinolaringología

Cited by 4 publications

References 40 publications

Physicochemical and Tissue Response of PLA Nanofiber Scaffolds Sterilized by Different Techniques

Physicochemical and Tissue Response of PLA Nanofiber Scaffolds Sterilized by Different Techniques

Tissue engineering in otorhinolaryngology: A knowledge‐based analysis

Ear Tissue Engineering

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