Concomitant and discrete expressions of aldose reductase and sorbitol dehydrogenase in the male reproductive tract

Tripathi, Muktanand; Singh, Akhand Pratap; Gupta, Gopal; Rajender, Singh

doi:10.1016/j.acthis.2016.09.008

Cited by 5 publications

(3 citation statements)

References 24 publications

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“…ACP is secreted by Sertoli cells and detected in lysosomes of Leydig cells mediated lysis of abnormal sperms (Olayinka and Ore 2015). While, SDH is distributed in spermatogenic cells of seminiferous tubules and correlated with germ cell maturation via energy supply by conversion of sorbitol to fructose (Tripathi et al 2016). Remarkably, Lead acetate has been evidenced in testicular accumulation with subsequent upregulation of reactive oxygen species (ROS) generation along with antioxidants downregulation promoting cellular membrane harm via lipid peroxidation (El-Khadragy et al 2020).…”

Section: Discussionmentioning

confidence: 99%

Chlorella vulgaris or Spirulina platensis mitigate lead acetate-induced testicular oxidative stress and apoptosis with regard to androgen receptor expression in rats

Ibrahim

Shalaby

Elaziz

et al. 2021

Environ Sci Pollut Res

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The current research was constructed to throw the light on the protective possibility of Chlorella vulgaris (C. vulgaris) and Spirulina platensis (S. platensis) versus lead acetate-prompted testicular dysfunction in male rats. Forty rats were classi ed into four groups; i) control, ii) rats received Lead acetate (30 mg/kg bw), iii) rats were concomitantly received Lead acetate and C. vulgaris (300 mg/Kg bw), vi) rats were simultaneously treated with Lead acetate and S. platensis (300 mg/Kg bw) via oral gavage for 8 weeks. Lead acetate promoted testicular injury as expressed with fall in reproductive organ weights, and gonadosomatic index (GSI). Spermatogenesis disruption is indicated by Sperm cell count reduction, and increased sperm malformation percentage. Steroidogenesis deterioration is evoked by minimized serum testosterone along with maximized follicle-stimulating hormone (FSH), luteinizing hormone (LH) levels. Testicular oxidative, in ammatory, and apoptotic cascades are revealed by elevated Acid phosphatase (ACP) and Sorbitol Dehydrogenase (SDH) serum leakage, declined testicular total antioxidative capacity (TAC) with elevated total oxidative capacity (TOC), tumor necrosis factor alpha (TNF-α), Caspase-3 levels, lessened androgen receptor (AR) expression, and histopathological lesions versus control. Our research highlights that C. vulgaris or S. platensis therapy can modulate lead acetate-promoted testicular dysfunction via antioxidant, immunomodulatory, anti-apoptotic potentials promoted testicular histoarchitecture, and androgen receptor restoration with better impacts to S. platensis comparing to C. vulgaris.

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Section: Discussionmentioning

confidence: 99%

Chlorella vulgaris or Spirulina platensis mitigate lead acetate-induced testicular oxidative stress and apoptosis with regard to androgen receptor expression in rats

Ibrahim

Shalaby

Elaziz

et al. 2021

Environ Sci Pollut Res

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“…Sorbitol presented with similar levels in testis and epididymis in nondiabetic mice and a significant upregulation under hyperglycemic conditions at 24 weeks of age with concentrations rising 1.7-fold (172.9 ± 42.8 to 286.4 ± 102.0 pmol/µl) within the testis. It was previously suggested that the polyol pathway plays a significant role in testicular metabolism and spermatogenesis 24 . Thus, the enzymes of the polyol pathway, aldosereductase and sorbitol dehydrogenase were found most abundantly expressed in Sertoli and germ cells, respectively, in rodent testes 24,25 .…”

Section: Discussionmentioning

confidence: 99%

“…It was previously suggested that the polyol pathway plays a significant role in testicular metabolism and spermatogenesis 24 . Thus, the enzymes of the polyol pathway, aldosereductase and sorbitol dehydrogenase were found most abundantly expressed in Sertoli and germ cells, respectively, in rodent testes 24,25 . Furthermore, as sperm can utilize fructose as sole energy product, the polyol pathway was supposed to be active in testis 26,27 .…”

Section: Discussionmentioning

confidence: 99%

Hyperglycemia induces spermatogenic disruption via major pathways of diabetes pathogenesis

Maresch

Stute

Fleming

et al. 2019

Sci Rep

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Diabetes-induced hyperglycemia has previously been shown to impact on male sub-/infertility, however, still little is known about the underlying mechanisms. In the present study we have addressed three major biochemical pathways implicated in the pathogenesis of hyperglycemia induced organ damage (the advanced glycation end product (AGE) formation pathway, the diacylglycerol-protein kinase C pathway (PKC), and the polyol pathway) in both testis and epididymis of the Ins2Akita mouse model of Type 1 diabetes (T1DM). Hyperglycemia activated both the PKC and the polyol pathway in a significant and progressive manner within the testis, but not within the epididymis. While the AGE receptor was ubiquitiously expressed in the testis, concentrations of precursor methylglyoxal and AGE carboxymethyllysine were increased in both epididymis and testis in diabetic mice. However, AGEs did not activate intracellular pathways of ERK1, ERK2, Rela, Nrf-2, IkBkB, NFkB except CDC42, Akt1. In conclusion, two of the major pathways of hyperglycemia-induced organ damage were clearly activated within the testis of T1DM mice. This provides therapeutical opportunities in the treatment of diabetic male reproductive dysfunction.

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Diabetes mellitus and the impairment of male reproductive function: Possible signaling pathways

Barkabi-Zanjani

Ghorbanzadeh

Aslani

et al. 2020

Diabetes & Metabolic Syndrome: Clinical Research & Revi

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Concomitant and discrete expressions of aldose reductase and sorbitol dehydrogenase in the male reproductive tract

Cited by 5 publications

References 24 publications

Chlorella vulgaris or Spirulina platensis mitigate lead acetate-induced testicular oxidative stress and apoptosis with regard to androgen receptor expression in rats

Chlorella vulgaris or Spirulina platensis mitigate lead acetate-induced testicular oxidative stress and apoptosis with regard to androgen receptor expression in rats

Hyperglycemia induces spermatogenic disruption via major pathways of diabetes pathogenesis

Diabetes mellitus and the impairment of male reproductive function: Possible signaling pathways

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