Concomitant appearance of morphea and vitiligo in a patient with autoimmune thyroiditis

Yorulmaz, Ahu; Kiliç, S. Sırrı; Artüz, Ferda; Kahraman, Erhan

doi:10.5114/ada.2016.61610

Cited by 6 publications

(9 citation statements)

References 15 publications

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“…Although we did not report any chronic skin disease associated with SM, McNiff et al found lesions of classic morphea in 50% of patients with SM [4]. Unlike SM, classic morphea is frequently reported in association with other autoimmune skin diseases such as vitiligo, LSA, and discoid lupus erythematosus [13–15], the findings that were also recorded in our patients.…”

Section: Discussionsupporting

confidence: 67%

Superficial Morphea: Clinicopathological Characteristics and a Novel Therapeutic Outcome to Excimer Light Therapy

Mosbeh

Aboeldahab

El‐Khalawany

2019

Dermatology Research and Practice

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Introduction. Superficial morphea (SM) is an uncommon entity that was described in the literature without definitive correlation to localized scleroderma (LS) or other atrophoderma diseases. Aim. To demonstrate the clinicopathological features of SM and evaluate the efficacy of different therapeutic modalities in its management. Patients and methods. A total of 28 patients with SM were studied during the period from 2010 to 2015. Clinicopathological features and therapeutic outcomes were recorded and analyzed. Results. Clinically, SM was predominant in females (71.4%) with an average onset at 33 years of age and an average duration of 15 months. It was commonly presented as asymptomatic, darkly pigmented, and multiple and slightly indurated patches. The lesions were mostly ill-defined, large-sized, and located more on the trunk. Histologically, thickening of collagen fibers was observed either localized to the papillary dermis only (38.9%) or extended into the upper reticular dermis (61.1%). Elastic fibers were generally diminished in the upper reticular dermis while the number of fibroblasts and basal melanin pigmentation were increased in the majority of cases (92.9% and 96.4%, respectively). The most commonly associated diseases were diabetes mellitus (50%) and hepatitis C virus (HCV) infection (42.8%), and their incidence was significantly higher than that in patients with LS. Excimer light showed promising effective results in the treatment of most cases (78.9%) while the response to other modalities such as topical corticosteroid alone or in combination with tacrolimus or treatment with UVA1 alone was less effective (7.1%, 23.1%, and 5%, respectively). Conclusion. Our results proposed that SM is a distinctive clinicopathological variant and not a stage in the spectrum of LS. The novel response of SM to excimer light and not for UVA1 therapy also suggests the different therapeutic outcome of SM from LS. Although SM has a significant association with DM and HCV infection, they seem not to affect the course of the disease.

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Section: Discussionsupporting

confidence: 67%

Superficial Morphea: Clinicopathological Characteristics and a Novel Therapeutic Outcome to Excimer Light Therapy

Mosbeh

Aboeldahab

El‐Khalawany

2019

Dermatology Research and Practice

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“…An increased incidence of autoimmune diseases and autoantibodies has been reported in morphea patients [ 10 , 11 ]. Leitenberger et al reported autoimmune disorders to be seen equally commonly in adult and pediatric patients in their study where 245 morphea patients were evaluated [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

Morphea in Middle Anatolia, Turkey: a 5-year single-center experience

Bulur¹,

Erdoğan²,

Karapınar³

et al. 2017

pdia

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IntroductionMorphea, also referred to as localized scleroderma, is a rare fibrosing skin disorder of undetermined cause.AimWe report our single-center experience with morphea.Material and methodsThe study included 53 patients who were diagnosed with morphea by histopathology in our department between 2010 and 2015. Study data were collected retrospectively from the records of morphea patients.ResultsThe study included 53 patients (38 women, 15 men), and median age at onset was 39.0 (range: 8–85) years. Thirty (56.6%) patients had circumscribed morphea, 15 (28.3%) had generalized morphea, and 7 (13.2%) had linear morphea. One patient had mixed variant morphea (generalized, pansclerotic and linear morphea). ANA positivity was detected in 12 (22.6%) patients, but analysis for an association between the presence of ANA and morphea types, patients’ characteristics did not reveal any significant associations. We did not observe any extracutaneous manifestations in patients during follow-up period. There were 2 of 53 patients who had concomitant autoimmune disorder including vitiligo and spondyloarthritis. Thirty (56.6%) patients received only topical treatment. The patients with clinical improvement who were treated with systemic therapy received methotrexate (26.4%), colchicine (9.4%), mycophenolate mofetil (5.7%) and prednisolone (1.9%).ConclusionsOur results related to the demographic data of the patients and morphea types were consistent with the literature. On the other hand we observed that methotrexate was mostly used as an effective treatment option for generalized morphea.

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“…A concurrent presentation of vitiligo and morphea has been reported, and such an association is noted to be more frequent than can be attributed to mere coincidence 1 2 3 4 5 6 7 8 . Based on some aspects of our case, we can propose that a definite relationship exists between the two diseases.…”

Section: Discussionmentioning

confidence: 98%

“…Segmental vitiligo is a distinct form of vitiligo, a common acquired pigmentation disorder, with dermatomal distribution or distribution of lesions along the Blaschko's lines. A few reports have previously noted the concurrent presentation of morphea and vitiligo at distinctly separate sites in the same patient 1 2 3 4 5 6 7 8 . However, it is extremely rare that these two diseases occur at the same site in a patient.…”

Section: Introductionmentioning

confidence: 91%

Concurrence of Circumscribed Morphea and Segmental Vitiligo: A Case Report

2018

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Although a few reports have noted the concurrent presentation of morphea and vitiligo at distinctly separate sites in the same patient, it is extremely rare that these two conditions occur at the same sites in a patient. We report the case of a 10-year-old Korean girl with morphea and vitiligo and those lesions occurred at the same sites and progressed simultaneously. An autoimmunity and a cutaneous mosaicism was considered to be involved in such an unique presentation as the pathogenesis is concerned.

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Concomitant appearance of morphea and vitiligo in a patient with autoimmune thyroiditis

Cited by 6 publications

References 15 publications

Superficial Morphea: Clinicopathological Characteristics and a Novel Therapeutic Outcome to Excimer Light Therapy

Superficial Morphea: Clinicopathological Characteristics and a Novel Therapeutic Outcome to Excimer Light Therapy

Morphea in Middle Anatolia, Turkey: a 5-year single-center experience

Concurrence of Circumscribed Morphea and Segmental Vitiligo: A Case Report

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