Concomitant Staphylococcus aureus bacteriuria is associated with complicated S. aureus bacteremia

Pulcini, Céline; Matta, Matta; Mondain, V.; Gaudart, Jean; Girard-Pipau, F.; Mainardi, Jean–Luc; Dellamonica, P.

doi:10.1016/j.jinf.2009.08.001

Cited by 25 publications

(23 citation statements)

References 29 publications

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“…In humans, risk factors for systemic spread of urinary pathogens include neutropenia, renal disease, insulin administration, male sex, and the presence of indwelling urinary catheters (20). A strong association between bacteriuria and bacteremia is well established for Staphylococcus aureus (17,18,21,22) and also has been reported in Escherichia and Enterococcus infections (19,20,23). In human infants, both urine and blood cultures are recommended as part of sepsis evaluations in febrile patients; a full sepsis workup is usually considered to include blood, urine, and cerebrospinal fluid (CSF) culture, whereas a partial workup is limited to blood and urine cultures (24).…”

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confidence: 99%

Agreement between Parallel Canine Blood and Urine Cultures: Is Urine Culture the Poor Man's Blood Culture?

et al. 2018

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Bloodstream infections are a significant cause of morbidity and mortality in critically ill dogs, but due to cost and difficulties in sample acquisition, blood cultures are infrequently obtained. In ill dogs, urine cultures may be recommended as surrogates for blood cultures. In order to determine the outcome agreement between parallel urine and blood cultures, we retrospectively analyzed parallel blood and urine specimens submitted for culture from dogs at the NC State Veterinary Hospital between 2011 and 2016. Positive cultures were reported from 15% of the submitted blood specimens and 23% of the submitted urine specimens. A total of 295 urine and blood samples were submitted in parallel, with positive growth demonstrated in 14 concordant and five discordant pairs. A kappa statistic comparing blood and urine culture outcomes was 0.266 (fair) when all parallel growth was included, including concordant and discordant results, and 0.170 (poor) when restricted to parallel concordant growth. The sensitivity of urine to reflect concordant bloodstream bacterial organisms was 30%, with a specificity of 87%. The positive and negative predictive values were 30% and 88%, respectively. Of dogs with both specimens positive on bacterial culture, 7 of 7 (100%) with suspected urogenital infection sources were concordant. All dogs with discordant bloodstream and urinary infections were immunosuppressed. Urinary coagulase-positive isolates were most likely to be concordant with bloodstream infections. In conclusion, we found that urine culture is neither a substitute nor a screen for blood culture. Blood cultures should be performed in any potentially septic animal, especially those that are considered immunosuppressed.

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confidence: 99%

Agreement between Parallel Canine Blood and Urine Cultures: Is Urine Culture the Poor Man's Blood Culture?

et al. 2018

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“…Vertebral osteomyelitis and soft-tissue infections are also common causes of SAB associated with concurrent SABU [6]. Persistent SAB is associated with bacterial endocarditis (BE) in complicated SAB [5]. Our patient had SABU secondary to soft-tissue abscess with no evidence of persistent bacteraemia, osteomyelitis, or BE.…”

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confidence: 98%

“…Staphylococcus aureus bacteraemia (SAB) and SA bacteriuria (SABU) can occur in patients following indwelling urinary catheterization (IDUC) and urologic surgery. Up to 19.5 percent, patients can develop concurrent SAB and SABU without IDUC and more likely to have MSSA with community onset [5]. Vertebral osteomyelitis and soft-tissue infections are also common causes of SAB associated with concurrent SABU [6].…”

Section: Discussionmentioning

confidence: 99%

Staphylococcal Sepsis with Multiple Abscesses, Urinary Tract Infection, and Bilateral Renal Vein Thrombosis in a Patient with Uncontrolled Diabetes Mellitus

Khan

Hunter

Tan

et al. 2012

Case Reports in Medicine

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We report a case of staphylococcal sepsis with vascular complications including peripheral emboli and renal vein thrombosis. Bilateral renal vein thrombosis has not been reported as a complication of Staphylococcus aureus (SA) axillary abscess. Uncontrolled diabetes was the only detected predisposing medical condition. The patient was treated successfully with incision and drainage of soft-tissue abscesses and intravenous antibiotic for six weeks and with anticoagulation for renal vein thrombosis.

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“…We included prospectively 104 SAB evaluated by an Infectious Diseases specialist in two hospitals, with a concomitant urine sample performed in 68 patients. 2 Complications were defined by SAB with endocarditis, osteomyelitis, septic arthritis, or septic embolism/abcess. The 23 of 68 patients with SABU were more likely to have complications (47% vs. 19%, P ¼ 0.016) or septic shock (39% vs. 15%, P ¼ 0.027, unpublished results) in univariate analysis.…”

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confidence: 99%

Comment on: Staphylococcus aureus bacteremia (SAB) with associated S. aureus bacteriuria (SABU) as a predictor of complications and mortality

Pulcini

2010

Journal of Hospital Medicine

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We have read with great interest the article by Perez-Jorge et al. 1 This retrospective study included 118 Staphylococcus aureus bacteremia (SAB) in 1 hospital, with a concomittant urine sample available for all patients. Complications were defined by SAB with endocarditis, osteomyelitis, septic arthritis, thrombophlebitis, septic shock, septic embolism/ abcess, persistant or recurrent SAB. The 28 of 118 patients with S. aureus bacteriuria (SABU) were more likely to have complications (64% vs. 33%, P ¼ 0.004) or septic shock (21% vs. 7%, P ¼ 0.035) in univariate analysis.We did a study with similar findings, thereby strenghtening the hypothesis that SABU is a predictor of complicated SAB. We included prospectively 104 SAB evaluated by an Infectious Diseases specialist in two hospitals, with a concomitant urine sample performed in 68 patients.

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Concomitant Staphylococcus aureus bacteriuria is associated with complicated S. aureus bacteremia

Cited by 25 publications

References 29 publications

Agreement between Parallel Canine Blood and Urine Cultures: Is Urine Culture the Poor Man's Blood Culture?

Agreement between Parallel Canine Blood and Urine Cultures: Is Urine Culture the Poor Man's Blood Culture?

Staphylococcal Sepsis with Multiple Abscesses, Urinary Tract Infection, and Bilateral Renal Vein Thrombosis in a Patient with Uncontrolled Diabetes Mellitus

Comment on: Staphylococcus aureus bacteremia (SAB) with associated S. aureus bacteriuria (SABU) as a predictor of complications and mortality

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