Staphylococcal Sepsis with Multiple Abscesses, Urinary Tract Infection, and Bilateral Renal Vein Thrombosis in a Patient with Uncontrolled Diabetes Mellitus

Khan, Malik A.; Hunter, Jonathan; Tan, Chee Eng; Seleem, Mostafa; Stride, Peter

doi:10.1155/2012/357502

Cited by 4 publications

(4 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is striking that previous case reports of renal vein thrombosis secondary to acute pyelonephritis have frequently documented newly diagnosed or poorly controlled diabetes mellitus . Our patient had severe hyperglycaemia and mild HHS on a background of poorly controlled diabetes and significant obesity.…”

Section: Discussionmentioning

confidence: 53%

See 1 more Smart Citation

Acute pyelonephritis with renal vein and inferior vena cava thrombosis and pulmonary emboli in poorly controlled type 2 diabetes and HHS

et al. 2016

View full text Add to dashboard Cite

Renal vein thrombosis is a rare complication of acute pyelonephritis. We report a case of a 56‐year‐old woman with poorly controlled type 2 diabetes mellitus who presented with acute pyelonephritis and hyperglycaemic hyperosmolar state (HHS), complicated by thrombosis of the renal vein extending into the inferior vena cava. She was managed with intravenous antibiotics, intravenous fluids and insulin and with therapeutic low molecular weight heparin, despite which she developed pulmonary emboli two days after the diagnosis of renal vein and inferior vena caval thrombosis. Following optimisation of the dalteparin dose with factor Xa monitoring and a prolonged course of antibiotics, she made a full recovery. Two months post‐treatment there was resolution of the renal vein thrombosis and pulmonary emboli with improvement of inflammation of the right kidney on repeat computer tomography scanning. This case highlights the need to recognise renal vein thrombosis and pulmonary emboli as complications of acute pyelonephritis, especially in combination with poorly controlled diabetes mellitus, which further increases the hypercoaguable state. Copyright © 2016 John Wiley & Sons.

show abstract

Section: Discussionmentioning

confidence: 53%

“…Renal vein thrombosis as a complication of acute pyelonephritis is rare and poorly recognised . The literature is confined to a few case reports . Acute pyelonephritis and sepsis can cause a hypercoaguable state which may predispose to thrombosis of the renal vein .…”

Section: Introductionmentioning

confidence: 99%

Acute pyelonephritis with renal vein and inferior vena cava thrombosis and pulmonary emboli in poorly controlled type 2 diabetes and HHS

et al. 2016

View full text Add to dashboard Cite

show abstract

“…However, there have been scattered case reports of systemic complications attributable to bacteremia after I&D—for example, a report of methicillin-sensitive staphylococcal sepsis with peripheral emboli, renal vein thrombosis, and acute kidney injury. 7…”

Section: Discussionmentioning

confidence: 99%

Fever and Abdominal Pain Following Incision and Drainage of a Cutaneous Abscess

Yock

Boyce

2014

Clin Pediatr (Phila)

View full text Add to dashboard Cite

“…20,24 Hay evidencia que demuestra que la colonización nasal y extranasal de Staphylococcus aureus tiene una prevalencia notable en personas con diagnóstico de DM, y que la prevalencia de sepsis por S. aureus en pacientes diabéticos es mayor que en los individuos sin DM. 20,25 De igual forma se ha observado una elevada incidencia de DM en pacientes con sepsis por bacterias gram-negativas como Klebsiella spp. 20 McKane et al fueron capaces de demostrar que un diagnóstico de DM y una hemoglobina glucosilada A mayor a 6.5% actúan como predictores independientes de sepsis adquirida en la comunidad en la población de pacientes en estado crítico.…”

Section: La Condición Clínica Y Riesgo De Infecciónunclassified

Diabetes mellitus y su impacto en la etiopatogenia de la sepsis

Machado-Villarroel

Montano-Candia

Dimakis-Ramírez

2017

Acta Médica Grupo Ángeles

View full text Add to dashboard Cite

Certain infectious diseases have a higher frequency and severity in patients with diabetes mellitus (DM), which substantially increases morbidity and mortality rates. DM acts as a predisposing factor for bacteremia seen in both the nosocomial and community settings. The greater incidence of infections in diabetics is caused by the accompanying hyperglycemia, which generate an immune dysfunction characterized by disorders of the neutrophilic granulocytes, diminished antioxidant activity and humoral immunity. Other complications of DM such as micro or macroangiopathy, neuropathy, urinary and gastrointestinal motility disorders, among others, contribute to the pathogenesis of infectious processes in these patients. It is thought that cross-linking of advanced glycation end products is associated with inactivation of immune components, contributing to a higher vulnerability to infections. An association between hyperglycemia and infection in critically ill patients has been proposed; however, evidence remains limited. Several risk factors infl uence negatively in the prognosis of severe sepsis, such as advanced age, immunosuppression and chronic alcoholism. There still is contradictory data concerning the impact that DM could exert on the prognosis of septic patients.

show abstract

Staphylococcal Sepsis with Multiple Abscesses, Urinary Tract Infection, and Bilateral Renal Vein Thrombosis in a Patient with Uncontrolled Diabetes Mellitus

Cited by 4 publications

References 15 publications

Acute pyelonephritis with renal vein and inferior vena cava thrombosis and pulmonary emboli in poorly controlled type 2 diabetes and HHS

Acute pyelonephritis with renal vein and inferior vena cava thrombosis and pulmonary emboli in poorly controlled type 2 diabetes and HHS

Fever and Abdominal Pain Following Incision and Drainage of a Cutaneous Abscess

Diabetes mellitus y su impacto en la etiopatogenia de la sepsis

Contact Info

Product

Resources

About