Conditions D'incorporation des acides gras élaïdisés aux triglycérides de réserve du rat blanc

Raulin, J; Loriette, CL; Clément, Gilles

doi:10.1016/0926-6542(63)90097-0

Cited by 3 publications

(1 citation statement)

References 6 publications

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“…Some authors showed that linoleate is predominantly acylated in the sn-2 position of triacylglycerols, whereas its trans isomers are esterified in the sn-1 and sn-3 positions (32)(33)(34)(35). This finding could explain the higher 14 C retention in triacylglycerols observed 2 h after infusion with both trans-18:2 (Fig.…”

Section: Acylation Of the Trans Isomers Of Linoleic And ␣-Linolenic Acidsmentioning

confidence: 97%

Desaturation and chain elongation of [1-14C]mono-trans isomers of linoleic and α-linolenic acids in perfused rat liver

Brétillon

Chardigny

Noël

et al. 1998

Journal of Lipid Research

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Trans polyunsaturated fatty acids are produced during heat treatment of oils, such as deodorization and frying. The detailed metabolic pathways of these trans isomers are not fully understood. In the present work, the desaturation and chain elongation of [1-14 C]linoleic acid, 9 cis ,12 trans -18:2, 9 trans ,12 cis -18:2, ␣ -linolenic acid, 9 cis , 12 cis ,15 trans -18:3 and 9 trans ,12 cis ,15 cis -18:3 were studied using a perfused rat liver model. After perfusion with both trans isomers of 18:2n-6, the 14 C was equally distributed between phospholipids and triacylglycerols, compared to the 70:30 distribution (phospholipids:triacylglycerols) observed after infusing linoleic acid. The corresponding distribution of 14 C after perfusion with both trans isomers of 18:3n-3 was comparable to what was obtained for ␣ -linolenic acid. The products of conversion were analyzed by combination of different radio chromatographic methods. 9 cis ,12 trans -18:2 was 16 times more converted into a C18:3n-6 fatty acid than linoleic acid into ␥ -linolenic acid. Trans -18:2 isomers were more elongated into "dead-end products" when compared to the conversion of linoleic acid into 20:2n-6 (from 2-to 5-times more). 9 cis ,12 cis ,15 trans -18:3 and 9 trans ,12 cis , 15 cis -18:3 were 2-and 10-times less converted to trans -20:5, respectively, than ␣ -linolenic acid into eicosapentaenoic acid. Moreover, 9 cis ,12 cis ,15 trans -18:3 and 9 trans ,12 cis , 15 cis -18:3 were equally and 2.5-times more elongated into "dead-end products", respectively, than ␣ -linolenic acid into 20:3n-3. The partitioning of the conversion between formation of desaturated and chain elongated products on the one hand and production of "dead-end products" on the other was also calculated. Compared to their cis analogs, 9 trans ,12 cis -18:2 and 9 trans ,12 cis ,15 cis -18:3 were elongated into trans "dead-end products" rather than being converted to desaturated and chain elongated trans -metabolites. On the other hand 9 cis ,12 cis ,15 trans -18:3 was more desaturated and chain elongated into 17 trans 20:5 rather than elongated into 17 trans -20:3.-Bretillon, L., J-M. Chardigny, J-P. Noël, and J-L. Sébédio. Desaturation and chain elongation of [1-14 C]mono-trans isomers of linoleic and ␣ -linolenic acids in perfused rat liver.

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Section: Acylation Of the Trans Isomers Of Linoleic And ␣-Linolenic Acidsmentioning

confidence: 97%

Desaturation and chain elongation of [1-14C]mono-trans isomers of linoleic and α-linolenic acids in perfused rat liver

Brétillon

Chardigny

Noël

et al. 1998

Journal of Lipid Research

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Distribution ldinsaturés-insaturés” des acides gras dans les triglycérides élaïdisés du rat

Raulin¹,

Clément²

1964

Biochimica et Biophysica Acta (BBA) - Specialized Section on Li

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Review-Assay and Metabolism of Altered Fatty Acids in Partially Hydrogenated Vegetable Oils

Beare-Rogers¹

1970

Canadian Institute of Food Technology Journal

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Conditions D'incorporation des acides gras élaïdisés aux triglycérides de réserve du rat blanc

Cited by 3 publications

References 6 publications

Desaturation and chain elongation of [1-14C]mono-trans isomers of linoleic and α-linolenic acids in perfused rat liver

Desaturation and chain elongation of [1-14C]mono-trans isomers of linoleic and α-linolenic acids in perfused rat liver

Distribution ldinsaturés-insaturés” des acides gras dans les triglycérides élaïdisés du rat

Review-Assay and Metabolism of Altered Fatty Acids in Partially Hydrogenated Vegetable Oils

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