Conducting polymer-silk biocomposites for flexible and biodegradable electrochemical sensors

Pal, Raktim; Farghaly, A. M.; Wang, Congzhou; Collinson, Maryanne M.; Kundu, Subhas C.; Yadavalli, Vamsi K.

doi:10.1016/j.bios.2016.03.010

Cited by 193 publications

(155 citation statements)

References 56 publications

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“…In addition, PPY has been explored as neural implants and drug delivery systems due to its conductive nature. The advantage of silk fibroin for bioconductive studies will lead to the development of electroactive cytocompatible and biodegradable material . The coated fibers show higher cell substrate compatibility and may thus be more appropriate for tissue engineering.…”

Section: Discussionmentioning

confidence: 99%

Fabrication and Characterization of Conductive Conjugated Polymer‐Coated Antheraea mylitta Silk Fibroin Fibers for Biomedical Applications

Kong

Gautrot

et al. 2017

Macromolecular Bioscience

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Conductive polymers are interesting materials for a number of biological and medical applications requiring electrical stimulation of cells or tissues. Highly conductive polymers (polypyrrole and polyaniline)/Antheraea mylitta silk fibroin coated fibers are fabricated successfully by in situ polymerization without any modification of the native silk fibroin. Coated fibers characterized by scanning electron microscopy confirm the silk fiber surface is covered by conductive polymers. Thermogravimetric analysis reveals preserved thermal stability of silk fiber after coating process. X-ray diffraction of degummed fiber diffraction peaks at around 2θ = 20.4 and 16.5 confirms the preservation of the β-sheet structure typical of degummed silk II fibers. This phenomenon implies that both polypyrrole and polyaniline chains form interactions with peptide linkages in degummed fiber macromolecules, without significantly disrupting protein assembly. Fourier transform infrared spectroscopy of coated fibers indicates hydrogen bonding and electrostatic interactions exist between silk fibroin macromolecules and conductive polymers. Resulting fibers display good conductive properties compared to corresponding conjugated polymers. In vitro analysis (live/dead assay) of the behavior of human immortalized keratinocytes (HaCaTs) on coated fibers demonstrates improved cell-adhesive properties and viability after polymers coating. Hence, polypyrrole- and polyaniline-coated A. mylitta silk fibers are suitable for application in cell culture and for tissue engineering, where electrical conduction properties are required.

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Section: Discussionmentioning

confidence: 99%

Fabrication and Characterization of Conductive Conjugated Polymer‐Coated Antheraea mylitta Silk Fibroin Fibers for Biomedical Applications

Kong

Gautrot

et al. 2017

Macromolecular Bioscience

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“…An organic, bioresorbable (yet not completely) electrochemical biosensor for specific detection of glucose was reported by Pal et al (Figure b). A poly(3,4‐ethylenedioxythiophene)‐poly(styrene sulfonate) (PEDOT:PSS) copolymer (conductive material) was dispersed (19%) in silk sericin‐based photoresist (SPP) to obtain a conductive photocurable ink.…”

Section: Bioresorbable Electrical Devicesmentioning

confidence: 91%

“…Copyright 2015, American Chemical Society. b) Left: Sketch of the fabrication process of the silk‐based electrochemical electrode . Middle: Photograph of a fabricated sensor on flexible silk substrate.…”

Section: Bioresorbable Electrical Devicesmentioning

confidence: 99%

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Bioresorbable Materials on the Rise: From Electronic Components and Physical Sensors to In Vivo Monitoring Systems

2020

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Over the last decade, scientists have dreamed about the development of a bioresorbable technology that exploits a new class of electrical, optical, and sensing components able to operate in physiological conditions for a prescribed time and then disappear, being made of materials that fully dissolve in vivo with biologically benign byproducts upon external stimulation. The final goal is to engineer these components into transient implantable systems that directly interact with organs, tissues, and biofluids in real‐time, retrieve clinical parameters, and provide therapeutic actions tailored to the disease and patient clinical evolution, and then biodegrade without the need for device‐retrieving surgery that may cause tissue lesion or infection. Here, the major results achieved in bioresorbable technology are critically reviewed, with a bottom‐up approach that starts from a rational analysis of dissolution chemistry and kinetics, and biocompatibility of bioresorbable materials, then moves to in vivo performance and stability of electrical and optical bioresorbable components, and eventually focuses on the integration of such components into bioresorbable systems for clinically relevant applications. Finally, the technology readiness levels (TRLs) achieved for the different bioresorbable devices and systems are assessed, hence the open challenges are analyzed and future directions for advancing the technology are envisaged.

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“…Modeling approaches are also involved to reveal theoretical performance of such materials. [22] Searching through the literature of the topic, the most recent publications are revolving around sensorics (K. Pal et al [23], Kanaparthi and Badhulika [24] Luvisi et al [25]). Rossiter et al recently claimed, the field of robotics will also implement and use biodegradables [26].…”

Section: Faculty Of Electrical Engineeringmentioning

confidence: 99%

Advances in Producing Functional Circuits on Biodegradable PCBs

Kovàcs

Géczy

Horváth

et al. 2016

Period. Polytech. Elec. Eng. Comp. Sci.

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Conducting polymer-silk biocomposites for flexible and biodegradable electrochemical sensors

Cited by 193 publications

References 56 publications

Fabrication and Characterization of Conductive Conjugated Polymer‐Coated Antheraea mylitta Silk Fibroin Fibers for Biomedical Applications

Fabrication and Characterization of Conductive Conjugated Polymer‐Coated Antheraea mylitta Silk Fibroin Fibers for Biomedical Applications

Bioresorbable Materials on the Rise: From Electronic Components and Physical Sensors to In Vivo Monitoring Systems

Advances in Producing Functional Circuits on Biodegradable PCBs

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