Conductive biocomposite hydrogels with multiple biophysical cues regulate schwann cell behaviors

Abstract

Peripheral nerve injuries are serious clinical events, and surgical treatment has certain limitations. Conductive hydrogels are promising biomaterials for neural tissue engineering, as they can enhance the functionality of neurons...

Silk‐based conductive materials for smart biointerfaces

“…Silk-based hydrogels have emerged as promising biological platforms and have been widely used in cell/drug carriers, extracellular matrix-like (ECM-like) scaffolds, and tissue fillers. [36][37][38] According to the hydrogel network formation conditions, the common cross-linking methods of silk-based hydrogel include physical cross-linking, chemical cross-linking, and enzyme-based or photo-based methods (cataloged as other crosslinking) as shown in Figure 2. Theoretically, physical cross-linked silk hydrogels are usually fabricated by accelerating molecular motions using heating, robust vortexing, or strong sonication (Figure 2A).…”

Silk fibroin hydrogels for biomedical applications

“…contributed to SC survival and proliferation, while the increased conductivity favored the functional behavior of SCs. 123 Importantly, topological microstructure design is also the focus of the nerve regeneration scaffolds. Gu et al reported a pure silk fibroin hydrogel with a high-strength and arrayed microgroove topography, showing a strong ability to promote directional outgrowth of axons and guide axonal sprouting.…”

Regulation of Tendon Stem Cell Behavior by Designed Nanoporous Topography of Microfibers

“…11 In recent years, with more and more evidence that cells are regulated not only by chemical signals but also by the biophysical properties of the extracellular environment, the study of biophysical signals has attracted people's attention. 12,13 There is a very important question about the biophysical clues: the topography of the extracellular environment and how stem cells interact with substrate topography. Electrospinning is a versatile technique of producing fiber structures similar to ECM for cell culture applications.…”

“…The microenvironment consists of an extracellular matrix (ECM), which serves as a repository for biochemical and biophysical cues, the latter of which can be presented in the form of nanomorphology and matrix stiffness . In recent years, with more and more evidence that cells are regulated not only by chemical signals but also by the biophysical properties of the extracellular environment, the study of biophysical signals has attracted people’s attention. , There is a very important question about the biophysical clues: the topography of the extracellular environment and how stem cells interact with substrate topography. Electrospinning is a versatile technique of producing fiber structures similar to ECM for cell culture applications. , At the same time, the flexible process parameters make it possible to construct nanotopography on the fiber surface. , …”