Conferin, potent antioxidant and anti-inflammatory isoflavone fromCaragana confertaBenth

Isoflavonoids of the Leguminosae

“…Conferin (10), the 3 0 -methyl ether of 6,7,3 0 ,4 0 -tetrahydroxyiso-avone, is another example of a 5-deoxyisoavone, and a minor constituent of the whole plant of Caragana conferta. 43 The DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging activity of 10 (IC 50 ¼ 19.1 AE 0.11 mM), ascribed to ortho-dihydroxy substitution of the A-ring, was superior to that of the control, butylated hydroxyanisole (IC 50 ¼ 44.3 AE 0.09 mM). In other assays, conferin (10) showed moderate inhibition of lipoxygenase compared to baicalein (5,6,7-trihydroxyavone).…”

“…In other assays, conferin (10) showed moderate inhibition of lipoxygenase compared to baicalein (5,6,7-trihydroxyavone). 43 Another minor constituent from the whole plant of C. conferta was described as caragin (11), but in a separate publication. 44 An uncommon C-methylated isoavone (12) characterised as the 6-C-methyl derivative of biochanin A (5,7dihydroxy-4 0 -methoxyisoavone) has been obtained from MeOH extracts of the young stems of Millettia pinnata (published under the synonym Derris indica).…”

“…65 Both compounds, which derive from 6,8-diprenylbiochanin A and 6,8-diprenylgenistein, respectively, have oxidised prenyl groups at C-8 of the A-ring, a feature that may account for their low cytotoxicity compared to analogues with non-oxidised prenyl substituents. In addition to 13, stem bark extracts of Erythrina poeppigiana yielded 41-44, which are prenylated derivatives either of genistein 7-methyl ether (41, 42) or 2 0 -hydroxygenistein 7-methyl ether (43,44). 46 Three of the latter (42)(43)(44) were evaluated in assays to measure binding affinity for the estrogen receptors ERa and ERb, but were only weakly active compared to 17b-estradiol.…”

“…In addition to 13, stem bark extracts of Erythrina poeppigiana yielded 41-44, which are prenylated derivatives either of genistein 7-methyl ether (41, 42) or 2 0 -hydroxygenistein 7-methyl ether (43,44). 46 Three of the latter (42)(43)(44) were evaluated in assays to measure binding affinity for the estrogen receptors ERa and ERb, but were only weakly active compared to 17b-estradiol. 46 The genus Flemingia Roxb.…”

Antioxidant profile of constituents isolated from Polygonatumverticillatum rhizomes

“…Therefore, antioxidants are vital inhibitors of lipid peroxidation not only for food protection but also as a defense mechanism of living cells against oxidative damage (Ibrahim et al, 2012). It has been reported that antioxidants prevent the destruction of b-cells and to prevent or inhibit oxidative stress in the human body as well as food products (Khan et al, 2010a). DPPH is a primary spectrophotometric method for evaluation of antioxidant potential of test compounds.…”