Confocal endomicroscopy for the diagnosis of gastric cancer in vivo

Kitabatake, Shusuke; Niwa, Yasumasa; Miyahara, Ryoji; Ohashi, Atsuto; Matsuura, Tamifusa; Iguchi, Yasutaka; Shimoyama, Yasuaki; Nagasaka, Tetsuro; Maeda, Osamu; Ando, Takafumi; Ohmiya, Naoki; Itoh, Akihiro; Hirooka, Yoshiki; Goto, Hidemi

doi:10.1055/s-2006-944855

Cited by 122 publications

(104 citation statements)

References 16 publications

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“…CLE has been shown to visualize histomorphologic features associated with various GI diseases, including Barrett's esophagus [2], gastric cancer [3], and colorectal neoplasia [4]. The field of view (FOV) of CLE, however, is limited to approximately 0.5 by 0.5 mm 2 .…”

Section: Introductionmentioning

confidence: 99%

Spectrally encoded confocal microscopy of esophageal tissues at 100 kHz line rate

Schlachter

Kang

Gora

et al. 2013

Biomed. Opt. Express

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Spectrally encoded confocal microscopy (SECM) is a reflectance confocal microscopy technology that uses a diffraction grating to illuminate different locations on the sample with distinct wavelengths. SECM can obtain line images without any beam scanning devices, which opens up the possibility of high-speed imaging with relatively simple probe optics. This feature makes SECM a promising technology for rapid endoscopic imaging of internal organs, such as the esophagus, at microscopic resolution. SECM imaging of the esophagus has been previously demonstrated at relatively low line rates (5 kHz). In this paper, we demonstrate SECM imaging of large regions of esophageal tissues at a high line imaging rate of 100 kHz. The SECM system comprises a wavelength-swept source with a fast sweep rate (100 kHz), high output power (80 mW), and a detector unit with a large bandwidth (100 MHz). The sensitivity of the 100-kHz SECM system was measured to be 60 dB and the transverse resolution was 1.6 µm. Excised swine and human esophageal tissues were imaged with the 100-kHz SECM system at a rate of 6.6 mm 2 /sec. Architectural and cellular features of esophageal tissues could be clearly visualized in the SECM images, including papillae, glands, and nuclei. These results demonstrate that largearea SECM imaging of esophageal tissues can be successfully conducted at a high line imaging rate of 100 kHz, which will enable whole-organ SECM imaging in vivo.

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Section: Introductionmentioning

confidence: 99%

Spectrally encoded confocal microscopy of esophageal tissues at 100 kHz line rate

Schlachter

Kang

Gora

et al. 2013

Biomed. Opt. Express

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“…Зарубежные ученые (S. Kitabatake, Y. Niwa, R. Miyahara и др.) в своем исследовании показали точность КЛЭМ в диагностике аденокарциномы желудка на уровне 96,2% [12]. Другая группа ученых (G. Bok, S. Jeon, J. Cho и др.)…”

Section: Discussionunclassified

The application of the modern endoscopic updating techniques for the detection of epithelial structures in gastric mucosa

Шулешова¹,

Zav’yalov²,

Kanareĭtseva³

et al. 2016

Dok. gastroenterol.

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“…41 It is expected to acquire a real-time endoscopic analysis for histology without the need for a biopsy during the endoscopic examination. [42][43][44][45][46] Currently, there are two different techniques: endoscopy-based confocal laser endomicroscopy (eCLE) and probe-based confocal laser endomicroscopy (pCLE). Both require an intravenous contrast injection (fluorescein) or a topical dye spray to enhance all of the vascular supplied mucosal structures.…”

Section: Atrophic Gastritis In Confocal Laser Endomicroscopic Imagementioning

confidence: 99%

What Have We Accomplished in Endoscopic Image Analysis for Atrophic Gastritis?

Kim

Uedo

2013

Korean J Helicobacter Up Gastrointest Res

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Identifying precancerous conditions such as atrophic gastritis and intestinal metaplasia (IM) has a crucial role in detecting high risk patients for gastric cancer. White light imaging (WLI) is a basic tool for diagnosing these premalignant conditions, however its low accuracy and high variability has been a serious problem in diagnosing these premalignant conditions. Several noble imaging technologies, such as magnifying endoscopy, narrow band imaging, autofluorescence imaging, and confocal laser endomicroscopy, provids us with chances of overcoming the limitations of conventional WLI. Autofluorescence images help us understand the extent of atrophic gastritis with vivid colors. Magnifying endoscopy with narrow band imaging shows microsurface structure and micrvascular architecture and is able to identify the degree of intestinal metaplasia by the presence of "light blue crest" sign. Confocal laser endomicroscopy produces reliable images of goblet cells that can replace biopsy. Usefulness of the new endoscopic imaging techniques for predicting gastric cancer development needs to be validated in clinical practice. Currently, it would be practical to apply magnifying endoscopy with narrow band imaging sequentially after white light endoscopy for identifying the presence of IM and atrophic gastritis. (Korean J Helicobacter Up Gastrointest Res 2013;13:6-19)

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Confocal endomicroscopy for the diagnosis of gastric cancer in vivo

Abstract: Confocal endomicroscopy is useful in the diagnosis of gastric cancer but good quality images cannot always be obtained. In the future, it may allow virtual biopsy and help reduce unnecessary biopsies.

Cited by 122 publications

References 16 publications

Spectrally encoded confocal microscopy of esophageal tissues at 100 kHz line rate

Spectrally encoded confocal microscopy of esophageal tissues at 100 kHz line rate

The application of the modern endoscopic updating techniques for the detection of epithelial structures in gastric mucosa

What Have We Accomplished in Endoscopic Image Analysis for Atrophic Gastritis?

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