Conformationally Restricted Dipeptide-Based Nanoparticles for Delivery of siRNA in Experimental Liver Cirrhosis

Biswas, Saikat; Yadav, Nitin; Juneja, Pinky; Mourya, Akash Kumar; Kaur, Simranpreet; Tripathi, Dinesh Mani; Chauhan, Virander Singh

doi:10.1021/acsomega.2c05292

Cited by 3 publications

(3 citation statements)

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“…As NR4A1 is an endogenous inhibitor of transforming growth factor signaling that promotes fibrosis, [82] the siNR4A1‐loaded RΔFRGD nanomaterials showed antifibrotic effects through protecting siNR4A1 from nucleic acid endonucleases and targeted delivering it to the site of hepatic sclerosis. These results highlight the potential of self‐assembled peptide nanomaterials as effective drug delivery platforms for the treatment of liver fibrosis [83] …”

Section: Self‐assembled Peptide Nanomaterialsmentioning

confidence: 77%

“…These results highlight the potential of self-assembled peptide nanomaterials as effective drug delivery platforms for the treatment of liver fibrosis. [83] Enzyme-guided self-assembly (EISA) provides an opportunity to realized self-assembly of peptides inside cells. EISA of peptides has been used to delivery dexamethasone (Dex) for antifibrotic therapy.…”

Section: Self-assembled Peptide Nanomaterialsmentioning

confidence: 99%

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Peptide‐Based Nanoarchitectonics for the Treatment of Liver Fibrosis

Huang

Zou

2023

ChemBioChem

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Liver fibrosis is a process of excessive accumulation of extracellular matrix caused by liver injury. Liver fibrosis can progress to cirrhosis or even liver cancer without proper intervention. Until now, no effective therapeutic drugs have been clinically approved for treating liver fibrosis. Hence, the development of safe and effective antifibrotic drugs is particularly important. As a representative biomaterial, peptides have been investigated as key components for constructing antifibrotic nanomaterials given their advantages of biological origination, synthetic availability, and good biocompatibility. Peptides serve as multifunctional motifs in antifibrotic nanomaterials, such as liver‐targeting molecules, antifibrotic molecules, and self‐assembling building blocks for the formation of the nanomaterials. In this review, we focus on peptide‐based nanoarchitectonics for treating liver fibrosis, including nanomaterials modified with liver‐targeting peptides, nanomaterials for the efficient delivery of antifibrotic peptides, and self‐assembled peptide nanomaterials for the delivery of antifibrotic drugs. The design rules of these peptide‐based nanomaterials are described. The antifibrotic mechanisms and effects of these peptide‐based nanomaterials in treating liver fibrosis and related diseases are highlighted. The challenges and future perspectives of using peptide‐based nanoarchitectonics for the treatment of liver fibrosis are discussed. These results are expected to accelerate the rational design and clinical translation of antifibrotic nanomaterials.

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Section: Self‐assembled Peptide Nanomaterialsmentioning

confidence: 77%

Section: Self-assembled Peptide Nanomaterialsmentioning

confidence: 99%

Peptide‐Based Nanoarchitectonics for the Treatment of Liver Fibrosis

Huang

Zou

2023

ChemBioChem

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“…Liver-targeting dipeptide-based siRNA carrier nanoparticles that can be used therapeutically for cirrhosis have been designed. It has been reported that nanoparticles accumulate in the liver and have a therapeutic effect [72].…”

Section: Usage Areas Of Dipeptides and Expectationsmentioning

confidence: 99%

Self-Assembled Short Peptide Nanostructures: ‘’Dipeptides’’

Dikici

Acet

Gök

et al. 2023

MANAS Journal of Engineering

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Dipeptides are short peptide molecules formed by the peptide bond between two amino acids, and they play significant roles in various biological processes (such as protein synthesis, nutrient absorption, cellular signaling, immune response). Short peptides have a prominent place in the design of self-assembling materials. In particular, dipeptides have gained considerable attention in the field of biotechnology as a type of self-organizing nanostructure due to their low cost, simplicity of synthesis, biocompatibility, and tunability of functionality. However, there is limited knowledge about peptide and protein-based nanostructures in the literature. Therefore, more information is needed on dipeptide nanostructures, especially in terms of their potential applications for biomedical purposes. This review focuses on dipeptide nanostructures, particularly their potential uses in biomedical applications, and provides a broader perspective on the advantages, challenges, synthesis, interactions, and applications of these nanostructures.

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